prikaz prve stranice dokumenta Transventricular and transpial absorption of cerebrospinal fluid into cerebral microvessels
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Scientific paper - Original scientific paper
Transventricular and transpial absorption of cerebrospinal fluid into cerebral microvessels
Collegium Antropologicum, 32 (2008), Suppl.; 43-50. urn:nbn:hr:105:693757
Bulat, Marin; Lupret, Veljko; Orešković, Darko; Klarica, Marijan

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Bulat, M., Lupret, V., Orešković, D. & Klarica, M. (2008). Transventricular and transpial absorption of cerebrospinal fluid into cerebral microvessels. Collegium Antropologicum, 32. (Suppl.), 43-50. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:693757

Bulat, Marin, et al. "Transventricular and transpial absorption of cerebrospinal fluid into cerebral microvessels." Collegium Antropologicum, vol. 32, no. Suppl., 2008, pp. 43-50. https://urn.nsk.hr/urn:nbn:hr:105:693757

Bulat, Marin, Veljko Lupret, Darko Orešković and Marijan Klarica. "Transventricular and transpial absorption of cerebrospinal fluid into cerebral microvessels." Collegium Antropologicum 32, no. Suppl. (2008): 43-50. https://urn.nsk.hr/urn:nbn:hr:105:693757

Bulat, M., et al. (2008) 'Transventricular and transpial absorption of cerebrospinal fluid into cerebral microvessels', Collegium Antropologicum, 32(Suppl.), pp. 43-50. Available at: https://urn.nsk.hr/urn:nbn:hr:105:693757 (Accessed 02 May 2024)

Bulat M, Lupret V, Orešković D, Klarica M. Transventricular and transpial absorption of cerebrospinal fluid into cerebral microvessels. Collegium Antropologicum [Internet]. 2008 January [cited 2024 May 02];32(Suppl.):43-50. Available at: https://urn.nsk.hr/urn:nbn:hr:105:693757

M. Bulat, V. Lupret, D. Orešković and M. Klarica, "Transventricular and transpial absorption of cerebrospinal fluid into cerebral microvessels", Collegium Antropologicum, vol. 32, no. Suppl., pp. 43-50, January 2008. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:693757. [Accessed: 02 May 2024]

Metadata
Title (english)Transventricular and transpial absorption of cerebrospinal fluid into cerebral microvessels
AuthorMarin Bulat
AuthorVeljko Lupret
AuthorDarko Orešković
AuthorMarijan Klarica
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
It is generally accepted that volume of cerebrospinal fluid (CSF) is secreted in brain ventricles and flows to subarachnoid space to be absorbed into dural venous sinuses or/and into lymphatics via perineural sheats of cranial nerves. Since 99% of CSF volume is water, in experiments on cats 3H-water was slowly infused into lateral ventricle and found that it does not flow to subarachnoid space but that it is rapidly absorbed transventricularly into periventricular capillaries. When 3H-water was infused in cortical subarachnoid space, it was absorbed locally into cerebral capillaries via pia mater. On the contrary, when macromolecule 3H-inulin is applied in CSF it is very slowly eliminated in bloodstream, and, with time, is carried by systolic-diastolic pulsations and mixing of CSF bidirectionally along CSF system. Thus, CSF volume (water) is absorbed rapidly into adjacent cerebral capillaries while inulin is distributed bidirectionally due to its long residence time in CSF Previously, the macromolecules have been used to study CSF volume hydrodynamics and with this misconception of CSF physiology arose.
Abstract (croatian)
Općenito se smatra da se volumen cerebrospinalnog likvora secernira u moždanim komorama i teče u subarahnoidni prostor, te se apsorbira u duralne venske sinuse ili/i u limfu putem perivaskularnih ovojnica kranijskih živaca. Budući da voda sačinjava 99% volumena likvora, u pokusima na mačkama sporo je infundirana 3H-voda u lateralne moždane komore, te je pokazano da ona ne teče u subarahnoidni prostor nego biva brzo apsorbirana u priležeće periventrikularne krvne kapilare. Kada je 3H-voda bila infundirana u kortikalni subarahnoidni prostor ona je kroz piju mater bila apsorbirana lokalno u priležeće cerebralne kapilare. Nasuprot tome, kada je 3H-inulin bio infundiran u likvorske prostore, ta je makromolekula bila veoma sporo odstranjivana u krv, te je tijekom vremena bila raznesena dvosmjerno uzduž likvorskog sustava uslijed sistoličko-dijastoličkih, naprijed-natrag pulzacija likvora i njegova miješanja. Dakle, volumen likvora (voda) se brzo apsorbira lokalno u priležeće moždane kapilare, dok makromolekule (inulin) bivaju dvosmjerno raznesene zbog dugotrajnog boravka u likvoru. Do sada su makromolekule bile korištene za izučavanje hidrodinamike likvora, što je dovelo do krivog shvaćanja fiziologije likvora.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCollegium Antropologicum
Numberingvol. 32, no. Suppl., pp. 43-50
p-ISSN0350-6134
URN:NBNurn:nbn:hr:105:693757
Publication2008-01
Document URLhttps://hrcak.srce.hr/24552
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 10:48:35