prikaz prve stranice dokumenta Microbiological surveillance of the surgical intensive care unit in Zagreb: a pivot for guideline-based therapy of severe sepsis
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Scientific paper - Original scientific paper
Microbiological surveillance of the surgical intensive care unit in Zagreb: a pivot for guideline-based therapy of severe sepsis
Collegium Antropologicum, 31 (2007), 4; 1093-1097. urn:nbn:hr:105:675556
Mihaljević, Ljiljana; Bedenić, Branka; Mihaljević, Slobodan; Majerović, Mate; Petrović, Pavo; Vasilj, Ivan

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Mihaljević, Lj., Bedenić, B., Mihaljević, S., Majerović, M., Petrović, P. & Vasilj, I. (2007). Microbiological surveillance of the surgical intensive care unit in Zagreb: a pivot for guideline-based therapy of severe sepsis. Collegium Antropologicum, 31. (4), 1093-1097. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:675556

Mihaljević, Ljiljana, et al. "Microbiological surveillance of the surgical intensive care unit in Zagreb: a pivot for guideline-based therapy of severe sepsis." Collegium Antropologicum, vol. 31, no. 4, 2007, pp. 1093-1097. https://urn.nsk.hr/urn:nbn:hr:105:675556

Mihaljević, Ljiljana, Branka Bedenić, Slobodan Mihaljević, Mate Majerović, Pavo Petrović and Ivan Vasilj. "Microbiological surveillance of the surgical intensive care unit in Zagreb: a pivot for guideline-based therapy of severe sepsis." Collegium Antropologicum 31, no. 4 (2007): 1093-1097. https://urn.nsk.hr/urn:nbn:hr:105:675556

Mihaljević, Lj., et al. (2007) 'Microbiological surveillance of the surgical intensive care unit in Zagreb: a pivot for guideline-based therapy of severe sepsis', Collegium Antropologicum, 31(4), pp. 1093-1097. Available at: https://urn.nsk.hr/urn:nbn:hr:105:675556 (Accessed 28 April 2024)

Mihaljević Lj, Bedenić B, Mihaljević S, Majerović M, Petrović P, Vasilj I. Microbiological surveillance of the surgical intensive care unit in Zagreb: a pivot for guideline-based therapy of severe sepsis. Collegium Antropologicum [Internet]. 2007 December [cited 2024 April 28];31(4):1093-1097. Available at: https://urn.nsk.hr/urn:nbn:hr:105:675556

Lj. Mihaljević, B. Bedenić, S. Mihaljević, M. Majerović, P. Petrović and I. Vasilj, "Microbiological surveillance of the surgical intensive care unit in Zagreb: a pivot for guideline-based therapy of severe sepsis", Collegium Antropologicum, vol. 31, no. 4, pp. 1093-1097, December 2007. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:675556. [Accessed: 28 April 2024]

Metadata
Title (english)Microbiological surveillance of the surgical intensive care unit in Zagreb: a pivot for guideline-based therapy of severe sepsis
AuthorLjiljana Mihaljević
AuthorBranka Bedenić
AuthorSlobodan Mihaljević
AuthorMate Majerović
AuthorPavo Petrović
AuthorIvan Vasilj
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
The aim of this retrospective study was to create guidelines for therapy of severe sepsis in surgical intensive care unit (ICU) for unknown causative agent based on antimicrobial susceptibility of causative bacteria. Seventy-four patients with severe sepsis from surgical ICU in 2003.-2005. were included in study. Their clinical and microbiological data were analyzed from the medical records. Antimicrobial susceptibility of the strains isolated from the blood-culture was tested by disk diffusion method according to CLSI (Clinical Laboratory Standard Institution). APACHE II score was used to predict the severity of illness. Statistical significance difference between results was tested by Mann-Whitney test and chi2 test. Important problem remained type of sepsis: mono-agent sepsis presented less therapeutic problem than sepsis caused with two or more agents (mixed sepsis). Methicillin-resistant Staphylococcus aureus (MRSA), Pseudomonas aeruginosa and Acinetobacter baumannii were predominant causative agents in both type of sepsis. There was remarkable increase of A. baumannii prevalence in 2005 compared to 2004 and to 2003. There was also decrease of MRSA prevalence in 2004 and 2005 compared to 2003. P. aeruginosa were the predominant causative agents in 2004. MRSA displayed good susceptibility to vancomycin and linezolide, whereas P. aeruginosa showed excellent susceptibility to ceftazidime and carbapenems. A. baumannii, third predominant causative agent, exhibited excellent susceptibility to ampicillin+ sulbactam and carbapenems. The recommended therapy is empirical and should cover all important pathogens.
Abstract (croatian)
Retrospektivnom studijom od 01.01.2003. godine do 31.12.2005. godine kod 74 bolesnika iz kirurškog JIL-a KBC-a Zagreb, pratili smo promjene prevalencije uzročnika sepse koristeći se pri tome njihovim kliničkim i mikrobiološkim podacima. Cilj rada bio je odrediti smjernice za početnu antibiotsku terapiju teške sepse kod bolesnika u kirurškom JIL-u. Antimikrobna osjetljivost uzročnika izoliranih iz hemokulture određivana je metodom disk-difuzije prema CLSI (Clinical Laboratory Standard Institution). APACHE II score korišten je za procjenu težine i ishoda bolesti. Mann-Whitney i c2 test služili su za statističku obradu podataka, a kao granica statističke značajnosti uzet je p<0.05. Polimikrobna sepsa je bila posebno težak problem, kako za određivanje definitivne antibiotske terapije, tako i za određivanje empirijske antibiotske terapije. Izolirano je deset različitih uzročnika sepse, a najčešći su: meticilin-rezistentni Staphylococcus aureus (MRSA), Pseudomonas aeruginosa i Acinetobacter baumannii. Njihova prevalencija se mijenjala kroz te tri godine, tako da je MRSA bila vodeći uzročnik sepse u 2003. godini, P. aeruginosa u 2004. a A. baumannii u 2005. Kod naših bolesnika, MRSA je pokazala dobru osjetljivost na vankomicin i linezolid, P. aeruginosa na ceftazidim i karbapeneme, a A. baumannii na ampicilin+sulbaktam i karbapeneme.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCollegium Antropologicum
Numberingvol. 31, no. 4, pp. 1093-1097
p-ISSN0350-6134
URN:NBNurn:nbn:hr:105:675556
Publication2007-12
Document URLhttps://hrcak.srce.hr/26975
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 10:52:02