prikaz prve stranice dokumenta Aberrant glycosylation of Igg heavy chain in multiple myeloma
  Download
PDF 221.1 KB
Scientific paper - Original scientific paper
Aberrant glycosylation of Igg heavy chain in multiple myeloma
Collegium Antropologicum, 31 (2007), 1; 247-251. urn:nbn:hr:105:851262
Aurer, Igor; Lauc, Gordan; Dumić, Jerka; Rendić, Dubravko; Matišić, Danica; Miloš, Marija; Heffer-Lauc, Marija; Flogel, Mirna; Labar, Boris

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

Cite this document

Aurer, I., Lauc, G., Dumić, J., Rendić, D., Matišić, D., Miloš, M. ... Labar, B. (2007). Aberrant glycosylation of Igg heavy chain in multiple myeloma. Collegium Antropologicum, 31. (1), 247-251. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:851262

Aurer, Igor, et al. "Aberrant glycosylation of Igg heavy chain in multiple myeloma." Collegium Antropologicum, vol. 31, no. 1, 2007, pp. 247-251. https://urn.nsk.hr/urn:nbn:hr:105:851262

Aurer, Igor, Gordan Lauc, Jerka Dumić, Dubravko Rendić, Danica Matišić, Marija Miloš, Marija Heffer Lauc, Mirna Flogel and Boris Labar. "Aberrant glycosylation of Igg heavy chain in multiple myeloma." Collegium Antropologicum 31, no. 1 (2007): 247-251. https://urn.nsk.hr/urn:nbn:hr:105:851262

Aurer, I., et al. (2007) 'Aberrant glycosylation of Igg heavy chain in multiple myeloma', Collegium Antropologicum, 31(1), pp. 247-251. Available at: https://urn.nsk.hr/urn:nbn:hr:105:851262 (Accessed 08 November 2024)

Aurer I, Lauc G, Dumić J, Rendić D, Matišić D, Miloš M, and sur.. Aberrant glycosylation of Igg heavy chain in multiple myeloma. Collegium Antropologicum [Internet]. 2007 March [cited 2024 November 08];31(1):247-251. Available at: https://urn.nsk.hr/urn:nbn:hr:105:851262

I. Aurer, et al., "Aberrant glycosylation of Igg heavy chain in multiple myeloma", Collegium Antropologicum, vol. 31, no. 1, pp. 247-251, March 2007. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:851262. [Accessed: 08 November 2024]

Metadata
Title (english)Aberrant glycosylation of Igg heavy chain in multiple myeloma
AuthorIgor Aurer
AuthorGordan Lauc
AuthorJerka Dumić
AuthorDubravko Rendić
AuthorDanica Matišić
AuthorMarija Miloš
AuthorMarija Heffer-Lauc
AuthorMirna Flogel
AuthorBoris Labar
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Although the majority of eukaryotic proteins are glycosylated, there is a dearth of knowledge regarding protein sugar moieties and their changes in disease. Most multiple myeloma cases are characterized by production of monoclonal immunoglobulins (Ig). We studied galactosylation and sialylation of IgG heavy chains in 16 patients with IgG myeloma using lectin blotting and densitometry. In comparison to age and sex matched controls, galactosylation was reduced in multiple myeloma (median 317 vs. 362, range 153-410 vs. 309-447 relative units, p = 0.015, Student's t-test). Sialylation was stage dependent; samples from patients with stage IIA had lowest amounts of sialic acid, IIIA intermediate and IIIB highest (142.6 vs. 185.9 vs. 248.5 relative units, correlation coefficient r = 0.55). Both galactosylation and sialylation levels were independent of age, sex, treatment type, response to treatment, disease duration and IgG and b2 microglobulin concentration. These data indicate that multiple myeloma is characterized by aberrant immunoglobulin glycosylation.
Abstract (croatian)
Iako je većina eukariotskih proteina glikozilirana, nema puno podataka o šećerima vezanima na proteine niti o njihovim promjenama u pojedinim bolestima. Multipli mijelom je većinom karakteriziran stvaranjem monoklonskih imunoglobulina (Ig). Istraživali smo galaktozilaciju i sijalilaciju IgG teškog lanca u 16 bolesnika s IgG mijelomom koristeći specifično vezivanje lektina i denzitometriju. U usporedbi s kontrolama podjednake dobi i spola je u multiplom mijelomu smanjena galaktozilacija (medijan 317 naprema 362, raspon 153–410 naprema 309–447 relativnih jedinica, p=0.015 koristeći Studentov t-test). Sijalilacija je ovisila o stadiju. Najmanje sijalinske kiseline je nađeno u uzorcima bolesnika sa stadijem IIA, nešto više u onih s IIIA, a najviše u IIIB stadiju (142,6 naprema 185,9 naprema 248,5 relativnih jedinica, koeficijent korelacije r=0,55). Ni razina galaktozilacije niti sijalilacije nisu ovisile o dobi, spolu, vrsti liječenja, odgovoru na liječenje, trajanju bolesti, koncentraciji IgG ili β2 mikroglobulina. Ovi podaci ukazuju da je multipli mijelom karakteriziran poremećajem glikozilacije imunoglobulina.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCollegium Antropologicum
Numberingvol. 31, no. 1, pp. 247-251
p-ISSN0350-6134
URN:NBNurn:nbn:hr:105:851262
Publication2007-03
Document URLhttps://hrcak.srce.hr/27277
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 10:56:59