prikaz prve stranice dokumenta Deletion polymorphism of the angiotensin I-converting enzyme gene in elderly patients with coronary heart disease
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Scientific paper - Original scientific paper
Deletion polymorphism of the angiotensin I-converting enzyme gene in elderly patients with coronary heart disease
Collegium Antropologicum, 31 (2007), 1; 179-183. urn:nbn:hr:105:539969
Bergman Marković, Biserka; Bergovec, Mijo; Reiner, Željko; Sertić, Jadranka; Vincelj, Josip; Marković, Maja

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Bergman Marković, B., Bergovec, M., Reiner, Ž., Sertić, J., Vincelj, J. & Marković, M. (2007). Deletion polymorphism of the angiotensin I-converting enzyme gene in elderly patients with coronary heart disease. Collegium Antropologicum, 31. (1), 179-183. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:539969

Bergman Marković, Biserka, et al. "Deletion polymorphism of the angiotensin I-converting enzyme gene in elderly patients with coronary heart disease." Collegium Antropologicum, vol. 31, no. 1, 2007, pp. 179-183. https://urn.nsk.hr/urn:nbn:hr:105:539969

Bergman Marković, Biserka, Mijo Bergovec, Željko Reiner, Jadranka Sertić, Josip Vincelj and Maja Marković. "Deletion polymorphism of the angiotensin I-converting enzyme gene in elderly patients with coronary heart disease." Collegium Antropologicum 31, no. 1 (2007): 179-183. https://urn.nsk.hr/urn:nbn:hr:105:539969

Bergman Marković, B., et al. (2007) 'Deletion polymorphism of the angiotensin I-converting enzyme gene in elderly patients with coronary heart disease', Collegium Antropologicum, 31(1), pp. 179-183. Available at: https://urn.nsk.hr/urn:nbn:hr:105:539969 (Accessed 30 November 2024)

Bergman Marković B, Bergovec M, Reiner Ž, Sertić J, Vincelj J, Marković M. Deletion polymorphism of the angiotensin I-converting enzyme gene in elderly patients with coronary heart disease. Collegium Antropologicum [Internet]. 2007 March [cited 2024 November 30];31(1):179-183. Available at: https://urn.nsk.hr/urn:nbn:hr:105:539969

B. Bergman Marković, M. Bergovec, Ž. Reiner, J. Sertić, J. Vincelj and M. Marković, "Deletion polymorphism of the angiotensin I-converting enzyme gene in elderly patients with coronary heart disease", Collegium Antropologicum, vol. 31, no. 1, pp. 179-183, March 2007. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:539969. [Accessed: 30 November 2024]

Metadata
Title (english)Deletion polymorphism of the angiotensin I-converting enzyme gene in elderly patients with coronary heart disease
AuthorBiserka Bergman Marković
AuthorMijo Bergovec
AuthorŽeljko Reiner
AuthorJadranka Sertić
AuthorJosip Vincelj
AuthorMaja Marković
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Controversy exists as to whether the deletion/deletion (DD) genotype of angiotensin l-converting enzyme (ACE) gene polymorphism is associated with coronary heart disease (CHD). There are only a few studies dealing with this issue in the elderly, also with controversial results. The aim of this study was the assessment of correlation between genetic markers and the risk of CHD in the elderly. The results indicated DD genotype importance for CHD in the elderly as proven by discriminant analysis (chi2 = 25.77; df = 16; p = 0.0620). However, the use of univariate method demonstrated no correlation between DD genotype of ACE gene polymorphism and coronary artery disease. D allele of ACE gene was associated with higher activities of ACE plasma. A weak, but increased risk of MI is associated with high frequency of DD genotype in the elderly. Strong correlation between ACE polymorphism and ACE plasma activities was demonstrated.
Abstract (croatian)
Povezanost delecijskog alela (DD genotip) angiotenzin konvertirajućeg enzima (ACE) sa koronarnom bolesti srca (KBS) je dvojbena. Malo je studija posvećeno tom problemu za stariju životnu dob, čiji rezultati su također dvojbeni. Cilj ovog rada je bio procijeniti povezanosti genetskih markera i rizika za KBS u starosti. Rezultati pokazuju da DD genotip ima prediktivnu vrijednost za KBS u starosti prikazano diskriminacijskom analizom (c2=25,77; df=16; P=0.0620). Međutim upotrebljavajući univarijatnu metodu povezanost DD genotipa i KBS nije dokazana. Vrijednost aktivnosti plazmatskog ACE u direktnoj je povezanosti s delecijskim polimorfizmom ACE gena. Zaključak: Povezanost DD genotipa i rizika za KBS u starijoj životnoj dobi također postoji. Prikazana je jaka povezanost ACE polimorfizma i vrijednosti aktivnosti plazmatskog ACE.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCollegium Antropologicum
Numberingvol. 31, no. 1, pp. 179-183
p-ISSN0350-6134
URN:NBNurn:nbn:hr:105:539969
Publication2007-03
Document URLhttps://hrcak.srce.hr/27314
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 10:56:39