prikaz prve stranice dokumenta DNA methylation as a regulatory mechanism for gene expression in mammals
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Scientific paper - Original scientific paper
DNA methylation as a regulatory mechanism for gene expression in mammals
Collegium Antropologicum, 30 (2006), 3; 665-671. urn:nbn:hr:105:445358
Šerman, Alan; Vlahović, Maja; Šerman, Ljiljana; Bulić-Jakuš, Floriana

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Šerman, A., Vlahović, M., Šerman, Lj. & Bulić Jakuš, F. (2006). DNA methylation as a regulatory mechanism for gene expression in mammals. Collegium Antropologicum, 30. (3), 665-671. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:445358

Šerman, Alan, et al. "DNA methylation as a regulatory mechanism for gene expression in mammals." Collegium Antropologicum, vol. 30, no. 3, 2006, pp. 665-671. https://urn.nsk.hr/urn:nbn:hr:105:445358

Šerman, Alan, Maja Vlahović, Ljiljana Šerman and Floriana Bulić Jakuš. "DNA methylation as a regulatory mechanism for gene expression in mammals." Collegium Antropologicum 30, no. 3 (2006): 665-671. https://urn.nsk.hr/urn:nbn:hr:105:445358

Šerman, A., et al. (2006) 'DNA methylation as a regulatory mechanism for gene expression in mammals', Collegium Antropologicum, 30(3), pp. 665-671. Available at: https://urn.nsk.hr/urn:nbn:hr:105:445358 (Accessed 27 December 2024)

Šerman A, Vlahović M, Šerman Lj, Bulić Jakuš F. DNA methylation as a regulatory mechanism for gene expression in mammals. Collegium Antropologicum [Internet]. 2006 September [cited 2024 December 27];30(3):665-671. Available at: https://urn.nsk.hr/urn:nbn:hr:105:445358

A. Šerman, M. Vlahović, Lj. Šerman and F. Bulić Jakuš, "DNA methylation as a regulatory mechanism for gene expression in mammals", Collegium Antropologicum, vol. 30, no. 3, pp. 665-671, September 2006. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:445358. [Accessed: 27 December 2024]

Metadata
Title (english)DNA methylation as a regulatory mechanism for gene expression in mammals
AuthorAlan Šerman
AuthorMaja Vlahović
AuthorLjiljana Šerman
AuthorFloriana Bulić-Jakuš
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Epigenetics refers to the study of heritable changes in gene expression that occur without a change in DNA sequence. In the last decade, it has been shown that epigenetic mechanisms provide an "extra" layer of transcriptional control that regulates genes expression. Three distinct mechanisms appear intricately related in initiating and sustaining epigenetic modifications: RNA-associated silencing, DNA methylation and histone modification. These mechanisms are critical components in the normal development and cell growth. DNA methylation is involved in transcriptional silencing of genes, regulation of expression of imprinted genes, a number of tumour suppressor genes in cancer and silencing of genes located on the inactive X chromosome. In this review, we are focused on the basic principles of DNA methylation as the main epigenetic mechanism for normal embryonic development and epigenetic alterations that contribute to carcinogenesis.
Abstract (croatian)
Nasljedne promjene u ekspresiji gena koje se nasljeđuju neovisno o promjenama slijeda baza u molekuli DNA definiraju pojam epigenetike. Zadnja dekada, pokazala je da epigenetski mehanizmi omogućavaju dodatnu regulaciju ekspresije gena na razini transkripcije. Tri sistema, uključujući metilaciju DNA, modifikaciju histona i RNA-posredovano djelovanje, danas se povezuju s regulacijom ekspresije gena. Oni su kritični regulatori kako embrionalnog razvoja tako i samog rasta stanica. Proces metilacije molekule DNA predstavlja epigenetski mehanizam uključen u inaktivaciju transkripcije gena, genomski imprinting, osigurava neaktivnost većine gena na inaktivnom X kromosomu u stanicama ženskog organizma kao i tumor supresor gena u raku. Ovim pregledom iznjeli smo osnovne principe metilacije DNA molekule kao glavnog epigenetskog mehanizma regulacije genske ekspresije, s težištem na njezinoj ulozi u normalnom embrionalnom razvoju te poremećajima koji dovode do razvoja raka.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCollegium Antropologicum
Numberingvol. 30, no. 3, pp. 665-671
p-ISSN0350-6134
URN:NBNurn:nbn:hr:105:445358
Publication2006-09
Document URLhttps://hrcak.srce.hr/27598
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 10:57:10