prikaz prve stranice dokumenta Serum concentration of zinc, copper, manganese and magnesium in patients with liver cirrhosis
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Scientific paper - Original scientific paper
Serum concentration of zinc, copper, manganese and magnesium in patients with liver cirrhosis
Collegium Antropologicum, 30 (2006), 3; 523-528. urn:nbn:hr:105:124635
Rahelić, Dario; Kujundžić, Milan; Romić, Željko; Brkić, Kristina; Petrovečki, Mladen

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Rahelić, D., Kujundžić, M., Romić, Ž., Brkić, K. & Petrovečki, M. (2006). Serum concentration of zinc, copper, manganese and magnesium in patients with liver cirrhosis. Collegium Antropologicum, 30. (3), 523-528. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:124635

Rahelić, Dario, et al. "Serum concentration of zinc, copper, manganese and magnesium in patients with liver cirrhosis." Collegium Antropologicum, vol. 30, no. 3, 2006, pp. 523-528. https://urn.nsk.hr/urn:nbn:hr:105:124635

Rahelić, Dario, Milan Kujundžić, Željko Romić, Kristina Brkić and Mladen Petrovečki. "Serum concentration of zinc, copper, manganese and magnesium in patients with liver cirrhosis." Collegium Antropologicum 30, no. 3 (2006): 523-528. https://urn.nsk.hr/urn:nbn:hr:105:124635

Rahelić, D., et al. (2006) 'Serum concentration of zinc, copper, manganese and magnesium in patients with liver cirrhosis', Collegium Antropologicum, 30(3), pp. 523-528. Available at: https://urn.nsk.hr/urn:nbn:hr:105:124635 (Accessed 01 January 2025)

Rahelić D, Kujundžić M, Romić Ž, Brkić K, Petrovečki M. Serum concentration of zinc, copper, manganese and magnesium in patients with liver cirrhosis. Collegium Antropologicum [Internet]. 2006 September [cited 2025 January 01];30(3):523-528. Available at: https://urn.nsk.hr/urn:nbn:hr:105:124635

D. Rahelić, M. Kujundžić, Ž. Romić, K. Brkić and M. Petrovečki, "Serum concentration of zinc, copper, manganese and magnesium in patients with liver cirrhosis", Collegium Antropologicum, vol. 30, no. 3, pp. 523-528, September 2006. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:124635. [Accessed: 01 January 2025]

Metadata
Title (english)Serum concentration of zinc, copper, manganese and magnesium in patients with liver cirrhosis
AuthorDario Rahelić
AuthorMilan Kujundžić
AuthorŽeljko Romić
AuthorKristina Brkić
AuthorMladen Petrovečki
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
The role of trace elements in the pathogenesis of liver cirrhosis and its complications is still not clearly understood. Serum concentrations of zinc, copper, manganese and magnesium were determined in 105 patients with alcoholic liver cirrhosis and 50 healthy subjects by means of plasma sequential spectrophotometer. Serum concentrations of zinc were significantly lower (median 0.82 vs. 11.22 micromol/L, p < 0.001) in patients with liver cirrhosis in comparison to controls. Serum concentrations of copper were significantly higher in patients with liver cirrhosis (median 21.56 vs. 13.09 micromol/L, p < 0.001) as well as manganese (2.50 vs. 0.02 micromol/L, p < 0.001). The concentration of magnesium was not significantly different between patients with liver cirrhosis and controls (0.94 vs. 0.88 mmol/L, p = 0.132). There were no differences in the concentrations of zinc, copper, manganese and magnesium between male and female patients with liver cirrhosis. Only manganese concentration was significantly different between Child-Pugh groups (p = 0.036). Zinc concentration was significantly lower in patients with hepatic encephalopathy in comparison to cirrhotic patients without encephalopathy (0.54 vs. 0.96 micromol/L, p = 0.002). The correction of trace elements concentrations might have a beneficial effect on complications and maybe progression of liver cirrhosis. It would be recommendable to provide analysis of trace elements as a routine.
Abstract (croatian)
Cilj istraživanja bio je odrediti serumske koncentracije cinka, bakra, mangana i magnezija u bolesnika s jetrenom cirozom i usporediti ih s koncentracijama u zdravih ispitanika. Serumske koncentracije navedenih elemenata u tragovima bile su određivane u 105 bolesnika s jetrenom cirozom i 50 ispitanika kontrolne skupine pomoću plazma sekvencijskog spektrofotometra. Serumske koncentracije cinka bile su statistički značajno niže u bolesnika s jetrenom cirozom u odnosu na ispitanike kontrolne skupine (medijan 0.82 prema 11.22 mol/L, p<0.001). Koncentracije bakra bile su značajno povišene u bolesnika s jetrenom cirozom u odnosu na kontrolnu skupinu (medijan 21.56 prema 13.09 mol/L, p<0.001) kao i koncentracije mangana (medijan 2.50 prema 0.02 mol/L, p<0.001). Koncentracije magnezija nisu bile značajno različite između bolesnika s jetrenom cirozom i ispitanika kontrolne skupine (p=0.132). Koncentracije cinka, bakra, mangana i magnezija nisu bile različite u muških i ženskih bolesnika s jetrenom cirozom. Serumske koncentracije mangana bile su statistički značajno različite između Child-Pughovih skupina (p=0.036), dok koncentracije cinka, bakra i magnezija nisu bile značajno različite između Child-Pughovih skupina. Značajno niže serumske koncentracije cinka pronađene su u bolesnika s jetrenom cirozom i portalnom encefalopatijom u usporedbi s bolesnicima bez portalne encefalopatije (0.54 prema 0.96 mol/L, p=0.002). Korekcija koncentracija elemenata u tragovima mogla bi imati pozitivan učinak na komplikacije a moguće i tijek jetrene ciroze, stoga bi bilo preporučljivo u bolesnika s jetrenom cirozom određivati serumske koncentracije elemenata u tragovima kao dio rutinske laboratorijske obrade.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCollegium Antropologicum
Numberingvol. 30, no. 3, pp. 523-528
p-ISSN0350-6134
URN:NBNurn:nbn:hr:105:124635
Publication2006-09
Document URLhttps://hrcak.srce.hr/27596
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 10:58:33