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Scientific paper - Original scientific paper
Subacute sclerosing panencephalitis: the continuing threat
Collegium Antropologicum, 30 (2006), 4; 959-963. urn:nbn:hr:105:649032
Vilibić Čavlek, Tatjana; Ljubin Sternak, Sunčanica; Žarković, Kamelija; Marušić Della Marina, Branka; Cvitanović Šojat, Ljerka; Bašnec, Anica; Kaić, Bernard; Turković, Branko; Mlinarić Galinović, Gordana

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Vilibić Čavlek, T., Ljubin Sternak, S., Žarković, K., Marušić Della Marina, B., Cvitanović Šojat, Lj., Bašnec, A. ... Mlinarić Galinović, G. (2006). Subacute sclerosing panencephalitis: the continuing threat. Collegium Antropologicum, 30. (4), 959-963. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:649032

Vilibić Čavlek, Tatjana, et al. "Subacute sclerosing panencephalitis: the continuing threat." Collegium Antropologicum, vol. 30, no. 4, 2006, pp. 959-963. https://urn.nsk.hr/urn:nbn:hr:105:649032

Vilibić Čavlek, Tatjana, Sunčanica Ljubin Sternak, Kamelija Žarković, Branka Marušić Della Marina, Ljerka Cvitanović Šojat, Anica Bašnec, Bernard Kaić, Branko Turković and Gordana Mlinarić Galinović. "Subacute sclerosing panencephalitis: the continuing threat." Collegium Antropologicum 30, no. 4 (2006): 959-963. https://urn.nsk.hr/urn:nbn:hr:105:649032

Vilibić Čavlek, T., et al. (2006) 'Subacute sclerosing panencephalitis: the continuing threat', Collegium Antropologicum, 30(4), pp. 959-963. Available at: https://urn.nsk.hr/urn:nbn:hr:105:649032 (Accessed 01 September 2024)

Vilibić Čavlek T, Ljubin Sternak S, Žarković K, Marušić Della Marina B, Cvitanović Šojat Lj, Bašnec A, and sur.. Subacute sclerosing panencephalitis: the continuing threat. Collegium Antropologicum [Internet]. 2006 December [cited 2024 September 01];30(4):959-963. Available at: https://urn.nsk.hr/urn:nbn:hr:105:649032

T. Vilibić Čavlek, et al., "Subacute sclerosing panencephalitis: the continuing threat", Collegium Antropologicum, vol. 30, no. 4, pp. 959-963, December 2006. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:649032. [Accessed: 01 September 2024]

Metadata
Title (english)Subacute sclerosing panencephalitis: the continuing threat
AuthorTatjana Vilibić Čavlek
AuthorSunčanica Ljubin Sternak
AuthorKamelija Žarković
AuthorBranka Marušić Della Marina
AuthorLjerka Cvitanović Šojat
AuthorAnica Bašnec
AuthorBernard Kaić
AuthorBranko Turković
AuthorGordana Mlinarić Galinović
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Clinical, epidemiological and laboratory findings of four patients with subacute sclerosing panencephalitis (SSPE), diagnosed in Croatia in 2002, were examined. Patient age at disease onset ranged from 5-11 years. All patients were vaccinated regularly with MMR-vaccine. Two patients had a history of measles infection at the age of six and seven months, respectively. In the other two patients, the disease started immediately after the varicella infection. Complement fixing antibody titre to the measles virus (MV) ranged from 1:1024 to 1:65536 in serum, and from 1:16 to 1:128 in cerebrospinal fluid (CSF). In CSF, no antibodies to varicella-zoster virus were found. Brain tissue samples were obtained at autopsy from two patients. In one patient, electron microscopy demonstrated intranuclear viral inclusions (MV nucleocapsids). MV antigen was detected in brain imprints using IFA in both of them. Viral RNA was found in brain tissue samples only, while plasma, serum and CSF were negative. Nucleotide sequence analysis showed that the viruses detected in brain tissue belong to the wild-type MV D6 genotype.
Abstract (croatian)
Analizirani su klinički, epidemiološki i laboratorijski nalazi četvero bolesnika sa subakutnim sklerozirajućim panencefalitisom (SSPE) u Hrvatskoj tijekom 2002 godine. Dob bolesnika iznosila je od 5–11 godina. Svi su bolesnici redovno cijepljeni protiv morbila (Morbili-Parotitis-Rubela cjepivo). Dvoje bolesnika je imalo anamnestički podatak o preboljelim morbilima u dobi od šest odnosno sedam mjeseci. U druga je dva bolesnika bolest počela neposredno nakon preboljelih vodenih kozica. Titar komplement-fiksirajućih protutijela na virus morbila (MV) iznosio je od 1:1024 do 1:65536 u serumu te od 1:16 do 1:128 u cerebrospinalnom likvoru (CSL). Protutijela na virus varicella-zoster u CSL nisu nađena. Postmortalno su dobiveni uzorci moždanog tkiva od dvoje bolesnika. U jednog je bolesnika elektronska mikroskopija pokazala intranuklearne virusne inkluzije (MV nukleokapside). Metodom IFA, MV antigen dokazan je u moždanom otisku u oba bolesnika. Virusna RNA nađena je samo u uzorcima moždanog tkiva, dok su plazma, serum i CSL bili negativni. Analizom sekvenci nukleotida dokazan je divlji tip MV D6 genotipa14.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCollegium Antropologicum
Numberingvol. 30, no. 4, pp. 959-963
p-ISSN0350-6134
URN:NBNurn:nbn:hr:105:649032
Publication2006-12
Document URLhttps://hrcak.srce.hr/27689
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 11:02:31