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Scientific paper - Original scientific paper
Of mice and men: teratomas and teratocarcinomas
Collegium Antropologicum, 30 (2006), 4; 921-924. urn:nbn:hr:105:412351
Bulić-Jakuš, Floriana; Ulamec, Monika; Vlahović, Maja; Sinčić, Nino; Katušić, Ana; Jurić-Lekić, Gordana; Šerman, Ljiljana; Krušlin, Božo; Belicza, Mladen

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Bulić Jakuš, F., Ulamec, M., Vlahović, M., Sinčić, N., Katušić, A., Jurić Lekić, G. ... Belicza, M. (2006). Of mice and men: teratomas and teratocarcinomas. Collegium Antropologicum, 30. (4), 921-924. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:412351

Bulić Jakuš, Floriana, et al. "Of mice and men: teratomas and teratocarcinomas." Collegium Antropologicum, vol. 30, no. 4, 2006, pp. 921-924. https://urn.nsk.hr/urn:nbn:hr:105:412351

Bulić Jakuš, Floriana, Monika Ulamec, Maja Vlahović, Nino Sinčić, Ana Katušić, Gordana Jurić Lekić, Ljiljana Šerman, Božo Krušlin and Mladen Belicza. "Of mice and men: teratomas and teratocarcinomas." Collegium Antropologicum 30, no. 4 (2006): 921-924. https://urn.nsk.hr/urn:nbn:hr:105:412351

Bulić Jakuš, F., et al. (2006) 'Of mice and men: teratomas and teratocarcinomas', Collegium Antropologicum, 30(4), pp. 921-924. Available at: https://urn.nsk.hr/urn:nbn:hr:105:412351 (Accessed 06 May 2024)

Bulić Jakuš F, Ulamec M, Vlahović M, Sinčić N, Katušić A, Jurić Lekić G, and sur.. Of mice and men: teratomas and teratocarcinomas. Collegium Antropologicum [Internet]. 2006 December [cited 2024 May 06];30(4):921-924. Available at: https://urn.nsk.hr/urn:nbn:hr:105:412351

F. Bulić Jakuš, et al., "Of mice and men: teratomas and teratocarcinomas", Collegium Antropologicum, vol. 30, no. 4, pp. 921-924, December 2006. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:412351. [Accessed: 06 May 2024]

Metadata
Title (english)Of mice and men: teratomas and teratocarcinomas
AuthorFloriana Bulić-Jakuš
AuthorMonika Ulamec
AuthorMaja Vlahović
AuthorNino Sinčić
AuthorAna Katušić
AuthorGordana Jurić-Lekić
AuthorLjiljana Šerman
AuthorBožo Krušlin
AuthorMladen Belicza
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Teratomas and teratocarcinomas are tumors containing tissue derivatives of all three germ-layers. They can be induced by transplantation of animal embryos to ectopic microenvironment. Development of malignant teratocarcinomas depends on embryonic stage, species-specificity and immunological competence of the host. In the man, teratomas and teratocarcinomas usually represent a subtype of germ-cell tumors but sacrococcygeal teratomas arise from the remnants of the pluripotent primitive streak. Undifferentiated embryonal carcinoma (EC) cells are responsible for the malignancy of experimental mouse teratocarcinomas. Mouse EC cells injected to the adult give rise to tumors and upon injection to early embryos to differentiated tissues--thus resembling normal mouse embryonic stem cells (mESC). Epigenetic changes rather than mutations are associated with transformation of mESC to EC cells. Human EC and ES cell-lines (hESC) contain chromosomal abnormalities and can form teratocarcinoma after transplantation. ES cells are among those proposed for cell replacement therapy in the man. Suicide gene introduction should be recommended prior to their use in vivo to ablate them in case of malignant transformation.
Abstract (croatian)
Teratomi i teratokarcinomi su tumori koji se sastoje od tkivnih derivata svih triju zametnih listića. Moguće ih je inducirati transplantacijom animalnih zametaka u ektopični mikrookoliš. Razvoj malignog teratokarcinoma ovisi o stadiju razvoja zametka, species-specifičnosti te imunološkoj kompetenciji domaćina. U čovjeka, teratomi i teratokarcinomi obično predstavljaju podtipove tumora spolnih stanica, ali sacrococcygealni teratom nastaje iz zaostataka pluripotentne primitivne pruge. Nediferencirane stanice embrionalnog karcinoma (EC) odgovorne su za malignost eksperimentalnog mišjeg teratokarcinoma. Mišje EC stanice injicirane odraslom stvaraju tumore, a injicirane u rane zametke diferencirana tkiva te stoga nalikuju normalnim mišjim matičnim stanicama zametka (mESC). Epigenetske promjene, prije nego li mutacije, povezane su s transformacijom mESC u EC stanice. Ljudske EC i ES stanične linije (hESC) sadrže kromosomske aberacije i mogu formirati teratokarcinom nakon transplantacije. ES stanice su među stanicama predloženim za staničnu nadomjesnu terapiju čovjeka. Trebalo bi preporučiti da se u njih unesu samoubilački geni prije upotrebe in vivo, kako bi se mogle odstraniti u slučaju maligne transformacije.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCollegium Antropologicum
Numberingvol. 30, no. 4, pp. 921-924
p-ISSN0350-6134
URN:NBNurn:nbn:hr:105:412351
Publication2006-12
Document URLhttps://hrcak.srce.hr/27640
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 11:03:11