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Scientific paper - Original scientific paper
The immunomodulation effect of allogenic blood transfusion in colorectal cancer: a new approach
Collegium Antropologicum, 30 (2006), 4; 885-893. urn:nbn:hr:105:574813
Sabalić, Srećko; Kovačević, Dujo; Glavić, Željko; Buković, Damir; Despot, Albert; Fajdić, Josip; Lukač, Josip; Šešo, Ivana

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Sabalić, S., Kovačević, D., Glavić, Ž., Buković, D., Despot, A., Fajdić, J. ... Šešo, I. (2006). The immunomodulation effect of allogenic blood transfusion in colorectal cancer: a new approach. Collegium Antropologicum, 30. (4), 885-893. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:574813

Sabalić, Srećko, et al. "The immunomodulation effect of allogenic blood transfusion in colorectal cancer: a new approach." Collegium Antropologicum, vol. 30, no. 4, 2006, pp. 885-893. https://urn.nsk.hr/urn:nbn:hr:105:574813

Sabalić, Srećko, Dujo Kovačević, Željko Glavić, Damir Buković, Albert Despot, Josip Fajdić, Josip Lukač and Ivana Šešo. "The immunomodulation effect of allogenic blood transfusion in colorectal cancer: a new approach." Collegium Antropologicum 30, no. 4 (2006): 885-893. https://urn.nsk.hr/urn:nbn:hr:105:574813

Sabalić, S., et al. (2006) 'The immunomodulation effect of allogenic blood transfusion in colorectal cancer: a new approach', Collegium Antropologicum, 30(4), pp. 885-893. Available at: https://urn.nsk.hr/urn:nbn:hr:105:574813 (Accessed 02 December 2024)

Sabalić S, Kovačević D, Glavić Ž, Buković D, Despot A, Fajdić J, and sur.. The immunomodulation effect of allogenic blood transfusion in colorectal cancer: a new approach. Collegium Antropologicum [Internet]. 2006 December [cited 2024 December 02];30(4):885-893. Available at: https://urn.nsk.hr/urn:nbn:hr:105:574813

S. Sabalić, et al., "The immunomodulation effect of allogenic blood transfusion in colorectal cancer: a new approach", Collegium Antropologicum, vol. 30, no. 4, pp. 885-893, December 2006. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:574813. [Accessed: 02 December 2024]

Metadata
Title (english)The immunomodulation effect of allogenic blood transfusion in colorectal cancer: a new approach
AuthorSrećko Sabalić
AuthorDujo Kovačević
AuthorŽeljko Glavić
AuthorDamir Buković
AuthorAlbert Despot
AuthorJosip Fajdić
AuthorJosip Lukač
AuthorIvana Šešo
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
The total number of 542 patients with colorectal cancer surgery have been analyzed in order to estimate the effect of receiving transfusion local recurrences, and the disease free - survival. It should be examined whether there are changes in general immunity indicators which would be connected with perioperative transfusion. A significant connection has been found between local recurrences and blood transfusion (p<0.0001), the most noticeable being in Dukes A (p =0.045), localization on rectum (p=0.036). The receiving of blood transfusion is linked significantly with disease free - survival reduction (p =0.0068; log rank), the most significant being in Dukes A stage (p =0.0123; log rank) and with localization on rectum (p=0.0231). The analysis of general immunity indicators has shown significant immunocompromitation of patients just before the surgery and this could have effect on immunomodulation caused by transfusion and just as on the treatment prognosis of colorectal carcinoma.
Abstract (croatian)
Analizirano je 542 bolesnika operiranih zbog kolorektalnog karcinoma radi procijene utjecaja primanja transfuzije na pojavu lokalnih recidiva i na period bez bolesti – preživljavanje. Istražene su promjene u pokazateljima opće imunosti i njihovu moguću povezanost sa perioperacijskom transfuzijom. Nađena je značajna povezanost pojave lokalnih recidiva i primanja transfuzije (p<0,0001), najizraženije kod Dukesa A (p=0,045), lokalizacije na rektumu i rektosigmoidu (p=0,036). Količina transfuzije najviše je povezana sa pojavom lokalnih recidiva kod Dukesa A (p=0,008), lokalizacije na rektumu (p=0,008). Primanje transfuzije (p=0,0123; log rank) značajno je povezano sa skraćenjem perioda bez bolesti – preživljavanje, najznačajnije kod Dukes A stadija (p=0,0123; log rank), te pri lokalizaciji na rektumu (p=0,0231; long rank). Analizom pokazatelja opće imunosti uočena je značajna imunokompromitacija bolesnika prije same operacije, što bi moglo djelovati na stupanj imunomodulacije uzrokovane transfuzijom, a tim i na prognozu liječenja kolorektalnog karcinoma.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCollegium Antropologicum
Numberingvol. 30, no. 4, pp. 885-893
p-ISSN0350-6134
URN:NBNurn:nbn:hr:105:574813
Publication2006-12
Document URLhttps://hrcak.srce.hr/27685
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 11:02:41