prikaz prve stranice dokumenta Genotype frequencies of UDP-glucuronosyltransferase 1A1 promoter gene polymorphism in the population of healthy Croatian pre-scholars
  Download
PDF 88.16 KB
Scientific paper - Original scientific paper
Genotype frequencies of UDP-glucuronosyltransferase 1A1 promoter gene polymorphism in the population of healthy Croatian pre-scholars
Collegium Antropologicum, 32 (2008), 3; 725-729. urn:nbn:hr:105:568328
Marinković, Natalija; Pašalić, Daria; Gršković, Branka; Ferenčak, Goran; Honović, Lorena; Stavljenić Rukavina, Ana

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

Cite this document

Marinković, N., Pašalić, D., Gršković, B., Ferenčak, G., Honović, L. & Stavljenić Rukavina, A. (2008). Genotype frequencies of UDP-glucuronosyltransferase 1A1 promoter gene polymorphism in the population of healthy Croatian pre-scholars. Collegium Antropologicum, 32. (3), 725-729. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:568328

Marinković, Natalija, et al. "Genotype frequencies of UDP-glucuronosyltransferase 1A1 promoter gene polymorphism in the population of healthy Croatian pre-scholars." Collegium Antropologicum, vol. 32, no. 3, 2008, pp. 725-729. https://urn.nsk.hr/urn:nbn:hr:105:568328

Marinković, Natalija, Daria Pašalić, Branka Gršković, Goran Ferenčak, Lorena Honović and Ana Stavljenić Rukavina. "Genotype frequencies of UDP-glucuronosyltransferase 1A1 promoter gene polymorphism in the population of healthy Croatian pre-scholars." Collegium Antropologicum 32, no. 3 (2008): 725-729. https://urn.nsk.hr/urn:nbn:hr:105:568328

Marinković, N., et al. (2008) 'Genotype frequencies of UDP-glucuronosyltransferase 1A1 promoter gene polymorphism in the population of healthy Croatian pre-scholars', Collegium Antropologicum, 32(3), pp. 725-729. Available at: https://urn.nsk.hr/urn:nbn:hr:105:568328 (Accessed 25 November 2024)

Marinković N, Pašalić D, Gršković B, Ferenčak G, Honović L, Stavljenić Rukavina A. Genotype frequencies of UDP-glucuronosyltransferase 1A1 promoter gene polymorphism in the population of healthy Croatian pre-scholars. Collegium Antropologicum [Internet]. 2008 September [cited 2024 November 25];32(3):725-729. Available at: https://urn.nsk.hr/urn:nbn:hr:105:568328

N. Marinković, D. Pašalić, B. Gršković, G. Ferenčak, L. Honović and A. Stavljenić Rukavina, "Genotype frequencies of UDP-glucuronosyltransferase 1A1 promoter gene polymorphism in the population of healthy Croatian pre-scholars", Collegium Antropologicum, vol. 32, no. 3, pp. 725-729, September 2008. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:568328. [Accessed: 25 November 2024]

Metadata
Title (english)Genotype frequencies of UDP-glucuronosyltransferase 1A1 promoter gene polymorphism in the population of healthy Croatian pre-scholars
AuthorNatalija Marinković
AuthorDaria Pašalić
AuthorBranka Gršković
AuthorGoran Ferenčak
AuthorLorena Honović
AuthorAna Stavljenić Rukavina
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Increased serum bilirubin levels in patients with Gilbert syndrome (GS) are caused by reduction of hepatic activity of bilirubin glucuronosyltranferase to about 30% of normal. UGT1A1 genetic polymorphism with absent or very low bilirubin UDP-glucuronosyltransferase (B-UGT) activity is associated with Gilbert's syndrome (GS) and other hyperbilirubinemias. The genetic basis of GS is the insertion of two additional TA nucleotides (resulting in seven repeats of TA) in the TATAA box, present in proximal promoter of UGT1A1 gene. This study included 323 Croatian pre-scholars, including 164 boys and 159 girls. Statistical analysis showed significant difference for total bilirubin concentration between different genotypes (p < 0.001). Also, statistically significant difference for total bilirubin concentration was emphasized between genotypes 6/6 and 7/7 (p < 0.001) as well as 6/7 and 7/7 (p < 0.001). Higher total plasma bilirubin concentrations are significantly correlated with 7/7 genotype which is present in 9.8% of population studied.
Abstract (croatian)
Povišena koncentracija bilirubina u pacijenata s Gilbertovim sindromom (GS) uzrokovana je redukcijom aktivnosti jetrene bilirubin glukuronoziltransferaze na otprilike 30%. Polimorfizam gena za UGT1A1 s dokinutom ili jako smanjenom aktivnošću enzima UDP-glukuronoziltransferaze (B-UGT) je povezan s Gilbertovim sindromom te drugim vrstama hiperbilirubinemije. Genetska osnova GS je insercija dva dodatna TA nukleotida (što rezultira sedmerostrukim ponavljanjem TA) u TATA kutiji prisutnoj u proksimalnoj regiji promotora gena za UGT1A1. U ovoj studiji sudjelovalo je 323 hrvatske djece predškolske uzrasti uključujući 164 dječaka i 159 djevojčica. Statistička analiza pokazala je značajnu razliku u koncentraciji ukupnog bilirubina između genotipova (p<0.001). Nadalje, utvrđena je statistički značajna razlika u koncentraciji ukupnog bilirubina između genotipova 6/6 i 7/7 (p<0.001), kao i 6/7 i 7/7 (p<0.001). Povišene koncentracije ukupnog bilirubina u plazmi pokazale su značajnu povezanost sa genotipom 7/7 koji je bio prisutan u 9.8% populacije.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCollegium Antropologicum
Numberingvol. 32, no. 3, pp. 725-729
p-ISSN0350-6134
URN:NBNurn:nbn:hr:105:568328
Publication2008-09
Document URLhttps://hrcak.srce.hr/27040
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 11:07:23