prikaz prve stranice dokumenta Prognostic markers and gene abnormalities in subgroups of diffuse large B-cell lymphoma: single center experience
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Scientific paper - Original scientific paper
Prognostic markers and gene abnormalities in subgroups of diffuse large B-cell lymphoma: single center experience
Croatian Medical Journal, 49 (2008), 5; 618-624. https://doi.org/10.3325/cmj.2008.5.618
Korać, Petra; Dominis, Mara

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Korać, P. & Dominis, M. (2008). Prognostic markers and gene abnormalities in subgroups of diffuse large B-cell lymphoma: single center experience. Croatian Medical Journal, 49. (5), 618-624. doi: 10.3325/cmj.2008.5.618

Korać, Petra and Mara Dominis. "Prognostic markers and gene abnormalities in subgroups of diffuse large B-cell lymphoma: single center experience." Croatian Medical Journal, vol. 49, no. 5, 2008, pp. 618-624. https://doi.org/10.3325/cmj.2008.5.618

Korać, Petra and Mara Dominis. "Prognostic markers and gene abnormalities in subgroups of diffuse large B-cell lymphoma: single center experience." Croatian Medical Journal 49, no. 5 (2008): 618-624. https://doi.org/10.3325/cmj.2008.5.618

Korać, P. and Dominis, M. (2008) 'Prognostic markers and gene abnormalities in subgroups of diffuse large B-cell lymphoma: single center experience', Croatian Medical Journal, 49(5), pp. 618-624. doi: 10.3325/cmj.2008.5.618

Korać P, Dominis M. Prognostic markers and gene abnormalities in subgroups of diffuse large B-cell lymphoma: single center experience. Croatian Medical Journal [Internet]. 2008 October [cited 2024 November 04];49(5):618-624. doi: 10.3325/cmj.2008.5.618

P. Korać and M. Dominis, "Prognostic markers and gene abnormalities in subgroups of diffuse large B-cell lymphoma: single center experience", Croatian Medical Journal, vol. 49, no. 5, pp. 618-624, October 2008. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:507108. [Accessed: 04 November 2024]

Metadata
Title (english)Prognostic markers and gene abnormalities in subgroups of diffuse large B-cell lymphoma: single center experience
AuthorPetra Korać
AuthorMara Dominis
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
AIM: To explore the association between FOXP1, BCL2, and BCL6 gene expression in diffuse large B-cell lymphoma tumor cells and their association with the presence of FOXP3 lymphocytes. ----- METHODS: Samples of lymph nodes from 53 patients with newly diagnosed diffuse large B-cell lymphoma were taken at the time of the diagnosis and immunostained for CD10, MUM1, BCL6, BCL2, FOXP1, and FOXP3. Fluorescent in situ hybridization analysis was used for the detection of FOXP1, BCL2, and BCL6 gene abnormalities. The chi(2) test was used for data analysis. ----- RESULTS: FOXP1 protein was detected in 28 cases, genetic abnormalities involving the FOXP1 locus were found in 19 cases, and both were present in 13 cases (chi(2)=7.157; P=0.028). FOXP3 positive cells were detected in 37 cases. There was a significant relationship between BCL2 expression and FOXP1 genetic abnormalities (chi(2)= 5.858; P=0.016) and between BCL2 expression and BCL2 genetic abnormalities (chi(2)= 6.349; P=0.012). There was also an association between BCL6 and FOXP1 genetic abnormalities (chi(2)=8.497;P=0.004). ----- CONCLUSION: There was an association between FOXP1 and BCL2. The presence of FOXP3 positive cells had no influence on any of the analyzed markers.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCroatian Medical Journal
Numberingvol. 49, no. 5, pp. 618-624
p-ISSN0353-9504
DOIhttps://doi.org/10.3325/cmj.2008.5.618
URN:NBNurn:nbn:hr:105:507108
Publication2008-10
Document URLhttps://doi.org/10.3325/cmj.2008.5.618
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 11:08:14