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Scientific paper - Original scientific paper
Reversible "brain atrophy" in patients with Cushing's disease
Collegium Antropologicum, 32 (2008), 4; 1165-1170. urn:nbn:hr:105:443495
Gnjidić, Živko; Sajko, Tomislav; Kudelić, Nenad; Malenica, Maša; Vizner, Branka; Vrkljan, Milan; Hat, Josip; Rumboldt, Zoran

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Gnjidić, Ž., Sajko, T., Kudelić, N., Malenica, M., Vizner, B., Vrkljan, M. ... Rumboldt, Z. (2008). Reversible "brain atrophy" in patients with Cushing's disease. Collegium Antropologicum, 32. (4), 1165-1170. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:443495

Gnjidić, Živko, et al. "Reversible "brain atrophy" in patients with Cushing's disease." Collegium Antropologicum, vol. 32, no. 4, 2008, pp. 1165-1170. https://urn.nsk.hr/urn:nbn:hr:105:443495

Gnjidić, Živko, Tomislav Sajko, Nenad Kudelić, Maša Malenica, Branka Vizner, Milan Vrkljan, Josip Hat and Zoran Rumboldt. "Reversible "brain atrophy" in patients with Cushing's disease." Collegium Antropologicum 32, no. 4 (2008): 1165-1170. https://urn.nsk.hr/urn:nbn:hr:105:443495

Gnjidić, Ž., et al. (2008) 'Reversible "brain atrophy" in patients with Cushing's disease', Collegium Antropologicum, 32(4), pp. 1165-1170. Available at: https://urn.nsk.hr/urn:nbn:hr:105:443495 (Accessed 09 May 2024)

Gnjidić Ž, Sajko T, Kudelić N, Malenica M, Vizner B, Vrkljan M, and sur.. Reversible "brain atrophy" in patients with Cushing's disease. Collegium Antropologicum [Internet]. 2008 December [cited 2024 May 09];32(4):1165-1170. Available at: https://urn.nsk.hr/urn:nbn:hr:105:443495

Ž. Gnjidić, et al., "Reversible "brain atrophy" in patients with Cushing's disease", Collegium Antropologicum, vol. 32, no. 4, pp. 1165-1170, December 2008. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:443495. [Accessed: 09 May 2024]

Metadata
Title (english)Reversible "brain atrophy" in patients with Cushing's disease
AuthorŽivko Gnjidić
AuthorTomislav Sajko
AuthorNenad Kudelić
AuthorMaša Malenica
AuthorBranka Vizner
AuthorMilan Vrkljan
AuthorJosip Hat
AuthorZoran Rumboldt
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
During the past 25 years, we came across 60 patients with corticotroph pituitary adenomas and Cushing's disease. Neuroradiological examination showed prominent volume loss of the brain parenchyma, unexpected for the patient's age. This "brain atrophy" appeared to regress after surgical removal of pituitary adenoma and normalization of cortisol level. Observed difference between degree of "brain atrophy" in the Cushing's disease group and in the control group was statistically significant (p < 0.001). The degree of "brain atrophy" correlated well with the duration of Cushing's disease. Partial reversibility of "brain atrophy" was noticed during the 2nd, 3rd and 4th year after surgery and normalization of cortisol level. Increased cortisol level is one of the causative factors in pathogenesis of "brain atrophy". Loss of brain volume is at least partially reversible after normalization of cortisol levels.
Abstract (croatian)
Unazad 25 godina liječili smo 60 pacijenata sa kortikotropnim adenomima hipofize i Cushingovom bolesti. Neuroradiološko snimanje pokazalo je značajan gubitak volumena moždanog parenhima, neočetkivan za pacijentovu dob. Izgleda da ta »moždana atrofija« regredira nakon kirurškog odstranjenja adenoma hipofize i normalizacije razine kortizola. Razlika u utvrđenoj razini »atrofije mozga« u Cushingovoj bolesti i u kontrolnoj skupini je statistički značajna (p<0,001). Stupanj »moždane atrofije« korelira dobro sa trajanjem Cushingove bolesti. Djelomično povlačenje »atrofije mozga« primijećeno je dvije, tri i četiri godine nakon kirurškog liječenja i normalizacije razine kortizola. Povišena razina kortizola je jedan od uzročnih faktora u patogenezi »moždane atrofije«. Smanjenje volumena mozga je djelomično reverzibilno nakon normalizacije razine kortizola.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCollegium Antropologicum
Numberingvol. 32, no. 4, pp. 1165-1170
p-ISSN0350-6134
URN:NBNurn:nbn:hr:105:443495
Publication2008-12
Document URLhttps://hrcak.srce.hr/34303
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 11:12:04