prikaz prve stranice dokumenta Increased bone resorption and osteopenia are a part of the lymphoproliferative phenotype of mice with systemic over-expression of interleukin-7 gene driven by MHC class II promoter
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Scientific paper - Original scientific paper
Increased bone resorption and osteopenia are a part of the lymphoproliferative phenotype of mice with systemic over-expression of interleukin-7 gene driven by MHC class II promoter
Immunology Letters, 121 (2008), 2; 134-139. https://doi.org/10.1016/j.imlet.2008.10.002
Salopek, Daniela; Grčević, Danka; Katavić, Vedran; Kovačić, Nataša; Lukić, Ivan Krešimir; Marušić, Ana

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Salopek, D., Grčević, D., Katavić, V., Kovačić, N., Lukić, I. K. & Marušić, A. (2008). Increased bone resorption and osteopenia are a part of the lymphoproliferative phenotype of mice with systemic over-expression of interleukin-7 gene driven by MHC class II promoter. Immunology Letters, 121. (2), 134-139. doi: 10.1016/j.imlet.2008.10.002

Salopek, Daniela, et al. "Increased bone resorption and osteopenia are a part of the lymphoproliferative phenotype of mice with systemic over-expression of interleukin-7 gene driven by MHC class II promoter." Immunology Letters, vol. 121, no. 2, 2008, pp. 134-139. https://doi.org/10.1016/j.imlet.2008.10.002

Salopek, Daniela, Danka Grčević, Vedran Katavić, Nataša Kovačić, Ivan Krešimir Lukić and Ana Marušić. "Increased bone resorption and osteopenia are a part of the lymphoproliferative phenotype of mice with systemic over-expression of interleukin-7 gene driven by MHC class II promoter." Immunology Letters 121, no. 2 (2008): 134-139. https://doi.org/10.1016/j.imlet.2008.10.002

Salopek, D., et al. (2008) 'Increased bone resorption and osteopenia are a part of the lymphoproliferative phenotype of mice with systemic over-expression of interleukin-7 gene driven by MHC class II promoter', Immunology Letters, 121(2), pp. 134-139. doi: 10.1016/j.imlet.2008.10.002

Salopek D, Grčević D, Katavić V, Kovačić N, Lukić IK, Marušić A. Increased bone resorption and osteopenia are a part of the lymphoproliferative phenotype of mice with systemic over-expression of interleukin-7 gene driven by MHC class II promoter. Immunology Letters [Internet]. 2008 December 22 [cited 2024 November 29];121(2):134-139. doi: 10.1016/j.imlet.2008.10.002

D. Salopek, D. Grčević, V. Katavić, N. Kovačić, I. K. Lukić and A. Marušić, "Increased bone resorption and osteopenia are a part of the lymphoproliferative phenotype of mice with systemic over-expression of interleukin-7 gene driven by MHC class II promoter", Immunology Letters, vol. 121, no. 2, pp. 134-139, December 2008. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:080433. [Accessed: 29 November 2024]

Metadata
Title (english)Increased bone resorption and osteopenia are a part of the lymphoproliferative phenotype of mice with systemic over-expression of interleukin-7 gene driven by MHC class II promoter
AuthorDaniela Salopek
AuthorDanka Grčević
AuthorVedran Katavić
AuthorNataša Kovačić
AuthorIvan Krešimir Lukić
AuthorAna Marušić
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Mice with interleukin (IL)-7 transgene under the control of E(alpha) promoter over-express IL-7 in MHC class II-positive cells and develop specific immune phenotype, marked by an increase in CD45R(+) cells in both the bone marrow and peripheral blood. We show that IL-7 transgenic mice have a bone phenotype characterized by an age-related loss of trabecular bone in both axial and long bones. Osteopenia was the result of increased number of active osteoclasts on the surface of trabecular bone. Furthermore, IL-7 transgenic mice showed increased osteoclastic but unchanged osteoblastic potential of the bone marrow in vitro. IL-7 over-expression also created osteoclastogenic microenvironment within the bone marrow which promoted the commitment of precursors towards the osteoclast lineage. These findings are important for immunological disturbances where IL-7 is involved and where alterations in the immune system are accompanied by changes in bone metabolism, such as multiple myeloma, rheumatoid arthritis and postmenopausal osteoporosis.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleImmunology Letters
Numberingvol. 121, no. 2, pp. 134-139
p-ISSN0165-2478
DOIhttps://doi.org/10.1016/j.imlet.2008.10.002
URN:NBNurn:nbn:hr:105:080433
Publication2008-12-22
Document URLhttps://doi.org/10.1016/j.imlet.2008.10.002
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 11:14:51