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Scientific paper - Original scientific paper
Genome-wide expression analysis of peripheral blood identifies candidate biomarkers for schizophrenia
Journal of Psychiatric Research, 43 (2009), 13; 1073-1077. https://doi.org/10.1016/j.jpsychires.2009.03.005
Rojnić Kuzman, Martina; Medved, Vesna; Terzić, Janoš; Krainc, Dimitri

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Rojnić Kuzman, M., Medved, V., Terzić, J. & Krainc, D. (2009). Genome-wide expression analysis of peripheral blood identifies candidate biomarkers for schizophrenia. Journal of Psychiatric Research, 43. (13), 1073-1077. doi: 10.1016/j.jpsychires.2009.03.005

Rojnić Kuzman, Martina, et al. "Genome-wide expression analysis of peripheral blood identifies candidate biomarkers for schizophrenia." Journal of Psychiatric Research, vol. 43, no. 13, 2009, pp. 1073-1077. https://doi.org/10.1016/j.jpsychires.2009.03.005

Rojnić Kuzman, Martina, Vesna Medved, Janoš Terzić and Dimitri Krainc. "Genome-wide expression analysis of peripheral blood identifies candidate biomarkers for schizophrenia." Journal of Psychiatric Research 43, no. 13 (2009): 1073-1077. https://doi.org/10.1016/j.jpsychires.2009.03.005

Rojnić Kuzman, M., et al. (2009) 'Genome-wide expression analysis of peripheral blood identifies candidate biomarkers for schizophrenia', Journal of Psychiatric Research, 43(13), pp. 1073-1077. doi: 10.1016/j.jpsychires.2009.03.005

Rojnić Kuzman M, Medved V, Terzić J, Krainc D. Genome-wide expression analysis of peripheral blood identifies candidate biomarkers for schizophrenia. Journal of Psychiatric Research [Internet]. 2009 September [cited 2024 April 27];43(13):1073-1077. doi: 10.1016/j.jpsychires.2009.03.005

M. Rojnić Kuzman, V. Medved, J. Terzić and D. Krainc, "Genome-wide expression analysis of peripheral blood identifies candidate biomarkers for schizophrenia", Journal of Psychiatric Research, vol. 43, no. 13, pp. 1073-1077, September 2009. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:909001. [Accessed: 27 April 2024]

Metadata
Title (english)Genome-wide expression analysis of peripheral blood identifies candidate biomarkers for schizophrenia
AuthorMartina Rojnić Kuzman
AuthorVesna Medved
AuthorJanoš Terzić
AuthorDimitri Krainc
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
The aim of this study was to analyze gene expression in blood of patients with newly-diagnosed schizophrenia during their first psychotic episode and subsequent remission. Whole blood samples were obtained from 32 untreated patients presenting with their first psychotic episode suggestive of schizophrenia and 32 age- and gender- matched controls. Using Affymetrix micoarrays, we identified significantly altered expression of 180 gene probes in psychotic patients compared to controls. A subset of 4 significantly changed genes was further confirmed with QRT PCR. The following genes were significantly altered in patients: glucose transporter, SLC2A3 (p<0.001) and actin assembly factor DAAM2 (p<0.001) were increased, whereas translation, zinc metallopeptidase, neurolysin 1 and myosin C were significantly decreased (p<0.05). Expression of these candidate markers was also analyzed in a longitudinal study (12-24 months) in 12 patients who achieved full remission. Interestingly, expression of DAAM2 returned to control levels in patients who were in remission after their first psychotic episode, suggesting that its expression correlates with diseases progression and/or response to treatment. In summary, we identified changes of gene expression from peripheral blood which might help discriminate patients with schizophrenia from controls. While these results are promising, especially for DAAM2 whose polymorphic variants have been found significantly associated with schizophrenia, it will be important to analyze larger cohorts of patients in order to firmly establish changes in gene expression as blood markers of schizophrenia.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleJournal of Psychiatric Research
Numberingvol. 43, no. 13, pp. 1073-1077
p-ISSN0022-3956
DOIhttps://doi.org/10.1016/j.jpsychires.2009.03.005
URN:NBNurn:nbn:hr:105:909001
Publication2009-09
Document URLhttps://doi.org/10.1016/j.jpsychires.2009.03.005
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 11:15:53