prikaz prve stranice dokumenta Efficacy and safety of budesonide/formeterol combination therapy in asthma patients
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Scientific paper - Original scientific paper
Efficacy and safety of budesonide/formeterol combination therapy in asthma patients
Collegium Antropologicum, 33 (2009), 2; 587-591. urn:nbn:hr:105:891222
Jakopović, Marko; Pavičić, Fadila; Redžepi, Gzim; Pleština, Sanja; Janković, Mateja; Franić, Zrinka; Šamija, Mirko; Samaržija, Miroslav

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Jakopović, M., Pavičić, F., Redžepi, G., Pleština, S., Janković, M., Franić, Z. ... Samaržija, M. (2009). Efficacy and safety of budesonide/formeterol combination therapy in asthma patients . Collegium Antropologicum, 33. (2), 587-591. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:891222

Jakopović, Marko, et al. "Efficacy and safety of budesonide/formeterol combination therapy in asthma patients ." Collegium Antropologicum, vol. 33, no. 2, 2009, pp. 587-591. https://urn.nsk.hr/urn:nbn:hr:105:891222

Jakopović, Marko, Fadila Pavičić, Gzim Redžepi, Sanja Pleština, Mateja Janković, Zrinka Franić, Mirko Šamija and Miroslav Samaržija. "Efficacy and safety of budesonide/formeterol combination therapy in asthma patients ." Collegium Antropologicum 33, no. 2 (2009): 587-591. https://urn.nsk.hr/urn:nbn:hr:105:891222

Jakopović, M., et al. (2009) 'Efficacy and safety of budesonide/formeterol combination therapy in asthma patients ', Collegium Antropologicum, 33(2), pp. 587-591. Available at: https://urn.nsk.hr/urn:nbn:hr:105:891222 (Accessed 30 April 2024)

Jakopović M, Pavičić F, Redžepi G, Pleština S, Janković M, Franić Z, and sur.. Efficacy and safety of budesonide/formeterol combination therapy in asthma patients . Collegium Antropologicum [Internet]. 2009 June [cited 2024 April 30];33(2):587-591. Available at: https://urn.nsk.hr/urn:nbn:hr:105:891222

M. Jakopović, et al., "Efficacy and safety of budesonide/formeterol combination therapy in asthma patients ", Collegium Antropologicum, vol. 33, no. 2, pp. 587-591, June 2009. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:891222. [Accessed: 30 April 2024]

Metadata
Title (english)Efficacy and safety of budesonide/formeterol combination therapy in asthma patients
Title (croatian)Učinkovitost i sigurnost kombinacije budezonida i formoterola u bolesnika sa astmom
AuthorMarko Jakopović
AuthorFadila Pavičić
AuthorGzim Redžepi
AuthorSanja Pleština
AuthorMateja Janković
AuthorZrinka Franić
AuthorMirko Šamija
AuthorMiroslav Samaržija
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Budesonide/formoterol as single inhaler was developed for treating asthma patients who are not adequately controlled on glucocorticoides alone. The aim of this study was to evaluate efficacy, safety and patient/physician satisfaction of budesonide/formoterol therapy.Total of 268 asthma patients (120 men, mean age 38.8 +/- 37.2 years, and 148 women, mean age 42.2 +/- 32 years) were included in the study. All patients received budesonide/formoterol bid (640 mcg of budesonide and 18 mcg of formoterol daily) during run-in period for three weeks. Patients were followed during 14 weeks at 5 visits. At each visit lung function (FEV1 and PEF) was measured,presence of side affects was recorded and questionnaire was given to patients and physicians to estimate the level of satisfaction with budesonide/formoterol therapy (1 very unsatisfied to 5 very satisfied). Significant improvement was noticed in FEV1, from 76.25% of predicted value to 86.94% (p < 0.01); and in PEF from 380.84 L/min to 442.29 L/min (p < 0.01) in all patients. At the end of the study patients' satisfaction with budesonide/formeterol therapy was significantly improved comparing with satisfaction with previously taken therapy, in average grade, from 2.94 to 4.56 (p < 0.01), and similar results were noticed with physicians' satisfaction, from 2.60 to 4.41 (p < 0.01). Budesonide/formoterol in single inhaler, significantly improved lung function in patients with asthma.
Abstract (croatian)
Kombinacija budezonida i formoterola u jednom inhalatoru koristi se u bolesnika koji nemaju dobru kontrolu astme uz inhalacijske kortikosteroide. Cilj ovog rada je procijeniti učinkovitost i sigurnost fiksne kombinacije budezonida i formoterola te procijeniti zadovoljstvo bolesnika i liječnika navedenom terapijom. U studiju je uključeno ukupno 120 ispitanika. Svi bolesnici su koristili budezonid/formoterol dva puta na dan u ukupnoj dozi 640 mcg budezonida i 18 mcg formoterola kroz tri tjedna. Bolesnici su praćeni tijekom 14 tjedana u 5 posjeta. Na svakoj posjeti mjerena je plućna funkcija, bilježeno prisustvo nuspojava, te su bolesnici i liječnici ispunjavali upitnik o zadovoljstvu liječenjem. Tijekom praćenja nađeno je značajno poboljšanje u plućnoj funkciju (FEV1 i PEF). Također, na kraju studije značajno veće zadovoljstvo liječenjem pokazano je i medu ispitanicima i među liječnicima. U konačnici, budezonid i formoterol u jednom inhalatoru značajno poboljšava plućnu funkciju, te zadovoljstvo liječenjem u bolesnika s astmom.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCollegium Antropologicum
Numberingvol. 33, no. 2, pp. 587-591
p-ISSN0350-6134
URN:NBNurn:nbn:hr:105:891222
Publication2009-06
Document URLhttps://hrcak.srce.hr/40561
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 11:20:05