prikaz prve stranice dokumenta Preoperative clonidine or levobupivacaine - effect on systemic inflammatory stress response
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Scientific paper - Original scientific paper
Preoperative clonidine or levobupivacaine - effect on systemic inflammatory stress response
Collegium Antropologicum, 33 (2009), 2; 573-577. urn:nbn:hr:105:424278
Peršec, Jasminka; Peršec, Zoran; Buković, Damir; Merc, Vlasta; Pavelić, Jasminka; Župić, Tomislav

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Peršec, J., Peršec, Z., Buković, D., Merc, V., Pavelić, J. & Župić, T. (2009). Preoperative clonidine or levobupivacaine - effect on systemic inflammatory stress response . Collegium Antropologicum, 33. (2), 573-577. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:424278

Peršec, Jasminka, et al. "Preoperative clonidine or levobupivacaine - effect on systemic inflammatory stress response ." Collegium Antropologicum, vol. 33, no. 2, 2009, pp. 573-577. https://urn.nsk.hr/urn:nbn:hr:105:424278

Peršec, Jasminka, Zoran Peršec, Damir Buković, Vlasta Merc, Jasminka Pavelić and Tomislav Župić. "Preoperative clonidine or levobupivacaine - effect on systemic inflammatory stress response ." Collegium Antropologicum 33, no. 2 (2009): 573-577. https://urn.nsk.hr/urn:nbn:hr:105:424278

Peršec, J., et al. (2009) 'Preoperative clonidine or levobupivacaine - effect on systemic inflammatory stress response ', Collegium Antropologicum, 33(2), pp. 573-577. Available at: https://urn.nsk.hr/urn:nbn:hr:105:424278 (Accessed 02 December 2024)

Peršec J, Peršec Z, Buković D, Merc V, Pavelić J, Župić T. Preoperative clonidine or levobupivacaine - effect on systemic inflammatory stress response . Collegium Antropologicum [Internet]. 2009 June [cited 2024 December 02];33(2):573-577. Available at: https://urn.nsk.hr/urn:nbn:hr:105:424278

J. Peršec, Z. Peršec, D. Buković, V. Merc, J. Pavelić and T. Župić, "Preoperative clonidine or levobupivacaine - effect on systemic inflammatory stress response ", Collegium Antropologicum, vol. 33, no. 2, pp. 573-577, June 2009. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:424278. [Accessed: 02 December 2024]

Metadata
Title (english)Preoperative clonidine or levobupivacaine - effect on systemic inflammatory stress response
Title (croatian)Prijeoperacijska primjena klonidina ili levobupivakaina - učinak na sustavni upalni odgovor organizma
AuthorJasminka Peršec
AuthorZoran Peršec
AuthorDamir Buković
AuthorVlasta Merc
AuthorJasminka Pavelić
AuthorTomislav Župić
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
With perioperative pain control it is possible to supervise immune system, release of inflammation mediators, and influence on treatment outcome. Use of analgetics before the pain stimulus (preventive analgesia) obstruct development of neuroplastic changes in central nervous system, and reduces pain. Investigation hypothesis was that preoperative epidural clonidine is more efficient in blockade of systemic inflammatory stress response comparing to levobupivacaine. Patients were allocated to three groups, according to preoperative epidural use of clonidine, levobupivacaine or saline (control group). Before operation, 1 h after the beginning, 1 h, 6 h, 12 h and 24 h after the operation following parameters were analyzed: interleukine-6, C-reactive protein and leukocyte count. There were no significant differences between groups in age, gender, body mass index and operation time. In preoperative clonidine group, we found significant reduction in interleukine-6 levels throughout investigation time, compared to preoperative levobupivacaine group and control group. Also, C-reactive protein was significantly lower at the end of investigation, compared to other two groups. Leukocyte count was lower, and within the normal range in all investigation times only in preoperative clonidine group. We demonstrated significant difference that support importance of clonidine central effect on pain pathways and systemic inflammatory blockade.
Abstract (croatian)
Potpunom kontrolom perioperacijske boli možemo nadzirati odgovor imunosnog sustava i oslobađanje medijatora upale, čime izravno utječemo na ishod liječenja. Primjena analgetika prije nastanka bolnog podražaja (preventivna analgezija) sprječava razvoj neuroplastičnih promjena u sredi{njem živčanom sustavu, te može smanjiti razinu boli. Hipoteza istraživanja je da prijeoperacijska epiduralna primjena klonidina značajno učinkovitije blokira bol i sustavni upalni odgovor organizma u odnosu na levobupivakain. Bolesnici su razvrstani u tri skupine, obzirom na prijeoperacijsku epiduralnu primjenu klonidina, levobupivakaina ili fiziolo{ke otopine (kontrolna skupina). Prije operacije, 1 h nakon početka operacije, te 1 h, 6 h, 12 h i 24 h nakon operacije analizirani su parametri: interleukin-6, C-reaktivni protein i leukociti. Između ispitivanih skupina nije bilo statistički značajne razlike u dobi, spolu, tjelesnoj masi i trajanju operacije. U skupini s klonidinom prije operacije dokazane su statistički značajno najniže vrijednosti interleukina-6 tijekom cijelog vremena ispitivanja, u usporedbi s skupinom s levobupivakainom prije operacije i kontrolnom skupinom ispitanika. Dokazane su značajno najniže vrijednosti C-reaktivnog proteina na kraju ispitivanja, u usporedbi s druge dvije skupine ispitanika. Vrijednosti leukocita su tijekom cijelog vremena ispitivanja značajno najniže i unutar normalnih granica jedino u skupini s klonidinom prije operacije. Istraživanjem su dokazane statistički značajne razlike, koje potvrđuju važnost centralnog učinka klonidina na puteve boli i blokadu upalnog odgovora organizma.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCollegium Antropologicum
Numberingvol. 33, no. 2, pp. 573-577
p-ISSN0350-6134
URN:NBNurn:nbn:hr:105:424278
Publication2009-06
Document URLhttps://hrcak.srce.hr/40557
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 11:21:03