prikaz prve stranice dokumenta Central origin of the antinociceptive action of botulinum toxin type A
  Download
PDF 179.16 KB
Scientific paper - Original scientific paper
Central origin of the antinociceptive action of botulinum toxin type A
Pharmacology, Biochemistry, and Behavior, 94 (2009), 2; 234-238. https://doi.org/10.1016/j.pbb.2009.08.012
Bach-Rojecky, Lidija; Lacković, Zdravko

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

Cite this document

Bach Rojecky, L. & Lacković, Z. (2009). Central origin of the antinociceptive action of botulinum toxin type A. Pharmacology, Biochemistry, and Behavior, 94. (2), 234-238. doi: 10.1016/j.pbb.2009.08.012

Bach Rojecky, Lidija and Zdravko Lacković. "Central origin of the antinociceptive action of botulinum toxin type A." Pharmacology, Biochemistry, and Behavior, vol. 94, no. 2, 2009, pp. 234-238. https://doi.org/10.1016/j.pbb.2009.08.012

Bach Rojecky, Lidija and Zdravko Lacković. "Central origin of the antinociceptive action of botulinum toxin type A." Pharmacology, Biochemistry, and Behavior 94, no. 2 (2009): 234-238. https://doi.org/10.1016/j.pbb.2009.08.012

Bach Rojecky, L. and Lacković, Z. (2009) 'Central origin of the antinociceptive action of botulinum toxin type A', Pharmacology, Biochemistry, and Behavior, 94(2), pp. 234-238. doi: 10.1016/j.pbb.2009.08.012

Bach Rojecky L, Lacković Z. Central origin of the antinociceptive action of botulinum toxin type A. Pharmacology, Biochemistry, and Behavior [Internet]. 2009 December [cited 2024 May 04];94(2):234-238. doi: 10.1016/j.pbb.2009.08.012

L. Bach Rojecky and Z. Lacković, "Central origin of the antinociceptive action of botulinum toxin type A", Pharmacology, Biochemistry, and Behavior, vol. 94, no. 2, pp. 234-238, December 2009. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:488242. [Accessed: 04 May 2024]

Metadata
Title (english)Central origin of the antinociceptive action of botulinum toxin type A
AuthorLidija Bach-Rojecky
AuthorZdravko Lacković
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Here we provide behavioural evidence for an axonal transport and the central origin of the antinociceptive effect of botulinum toxin type A (BTX-A). In rats we investigated the effectiveness of BTX-A on "mirror pain" induced by unilateral repeated intramuscular acidic saline injections (pH 4.0). Since experimental evidence suggest that bilateral pain induced by acidic saline is of central origin, peripheral application of BTX-A should have no effect on this type of pain. However, here we demonstrated that the unilateral subcutaneous BTX-A (5U/kg) application diminished pain on the ipsilateral, and on the contralateral side too. When injected into the proximal part of a distally cut sciatic nerve, BTX-A still reduced pain on the contralateral side. Colchicine, an axonal transport blocker, when injected into the ipsilateral sciatic nerve, prevented the effect of the peripheral BTX-A injection on both sides. Additionally, when BTX-A (1U/kg) was applied intrathecally in the lumbar cerebrospinal fluid, the bilateral hyperalgesia was also reduced. The results demonstrate the necessity of retrograde axonal transport and involvement of the central nervous system for the antinociceptive activity of BTX-A.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titlePharmacology, Biochemistry, and Behavior
Numberingvol. 94, no. 2, pp. 234-238
p-ISSN0091-3057
DOIhttps://doi.org/10.1016/j.pbb.2009.08.012
URN:NBNurn:nbn:hr:105:488242
Publication2009-12
Document URLhttps://doi.org/10.1016/j.pbb.2009.08.012
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 11:25:55