prikaz prve stranice dokumenta Comparative analysis of hepatocellular carcinoma in men and dogs
  Download
PDF 181.16 KB
Scientific paper - Original scientific paper
Comparative analysis of hepatocellular carcinoma in men and dogs
Collegium Antropologicum, 33 (2009), 3; 811-814. urn:nbn:hr:105:554314
Grabarević, Željko; Ćorić, Marijana; Seiwerth, Sven; Džaja, Petar; Artuković, Branka; Gudan Kurilj, Andrea; Beck, Ana; Hohšteter, Marko; Šoštarić-Zuckermann, Ivan-Conrado; Brčić, Luka; Hrstić, Irena

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

Cite this document

Grabarević, Ž., Ćorić, M., Seiwerth, S., Džaja, P., Artuković, B., Gudan Kurilj, A. ... Hrstić, I. (2009). Comparative analysis of hepatocellular carcinoma in men and dogs . Collegium Antropologicum, 33. (3), 811-814. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:554314

Grabarević, Željko, et al. "Comparative analysis of hepatocellular carcinoma in men and dogs ." Collegium Antropologicum, vol. 33, no. 3, 2009, pp. 811-814. https://urn.nsk.hr/urn:nbn:hr:105:554314

Grabarević, Željko, Marijana Ćorić, Sven Seiwerth, Petar Džaja, Branka Artuković, Andrea Gudan Kurilj, Ana Beck, et al. "Comparative analysis of hepatocellular carcinoma in men and dogs ." Collegium Antropologicum 33, no. 3 (2009): 811-814. https://urn.nsk.hr/urn:nbn:hr:105:554314

Grabarević, Ž., et al. (2009) 'Comparative analysis of hepatocellular carcinoma in men and dogs ', Collegium Antropologicum, 33(3), pp. 811-814. Available at: https://urn.nsk.hr/urn:nbn:hr:105:554314 (Accessed 22 November 2024)

Grabarević Ž, Ćorić M, Seiwerth S, Džaja P, Artuković B, Gudan Kurilj A, and sur.. Comparative analysis of hepatocellular carcinoma in men and dogs . Collegium Antropologicum [Internet]. 2009 September [cited 2024 November 22];33(3):811-814. Available at: https://urn.nsk.hr/urn:nbn:hr:105:554314

Ž. Grabarević, et al., "Comparative analysis of hepatocellular carcinoma in men and dogs ", Collegium Antropologicum, vol. 33, no. 3, pp. 811-814, September 2009. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:554314. [Accessed: 22 November 2024]

Metadata
Title (english)Comparative analysis of hepatocellular carcinoma in men and dogs
Title (croatian)Komparativna analiza hepatocelularnih karcinom ljudi i pasa
AuthorŽeljko Grabarević
AuthorMarijana Ćorić
AuthorSven Seiwerth
AuthorPetar Džaja
AuthorBranka Artuković
AuthorAndrea Gudan Kurilj
AuthorAna Beck
AuthorMarko Hohšteter
AuthorIvan-Conrado Šoštarić-Zuckermann
AuthorLuka Brčić
AuthorIrena Hrstić
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Concerning the important differences in the ethiopathology of hepatocelular carcinomas (HCC) in humans and dogs, our work describes the expression of epidermal growth factor receptor (EGFr), cytokeratine 19 (CK19), vascular endothelial growth factor (VEGF) and transforming growth factor beta receptor (TGFb-r) in tumors arising in both species. Investigation included 25 cases of human and 8 cases of dog tumors. All human cases were noted in cirrhotic livers, while in dogs the tissue adjacent to tumor was not changed. In humans in two cases hepatitis B virus (HBV) and in one case hepatitis C virus (HCV) were determined. Investigation showed lack of TGFb-r reaction in six cases of canine HCC, while in humans only one case was negative. In most tumors specific hepatocyte antigen Hepatocyte Paraffin 1 marker (Hep Par 1) was mainly positive with markedly decreased reaction compared to the normal hepatocytes, while cytokeratine 19 for billiary epithelium was negative. The result of our investigation rise the question about the possible role of tumor suppressor gene TGFb-r in the development of HCC in dogs and in the same time emphasizes its importance in human diseases.
Abstract (croatian)
S obzirom na značajne razlike etiopatologije hepatocelularnih carcinoma (HCC) ljudi i pasa, naš rad opisuje ekspresiju receptora epidermalnog faktora rasta (EGFr), citokeratina 19 (CK19), faktora rasta podrijetla vaskularnog endotela (VEGF) i receptora za transformirajući factor rasta beta (TGFb-r) u obje vrste. Istraživanje je obuhvatilo 25 slučajeva HCC u ljudi i 8 slučajeva HCC u pasa. U ljudi se ovaj tumor u svim slučajevima pojavio u jetri zahvaćenoj cirotičnim promjenama, dok je u pasa dio jetre nezahvaćen tumorom bio nepromijenjen. U ljudi je u dva slučaja utvrđena infekcija s virusom hepatitisa B, a u jednom s virusom hepatitisa C. Istraživanje je pokazalo izostanak reakcija na TGFb-r u šest tumora pasa, dok je ova reakcija izostala samo u jednom tumoru ljudi. Hepatocitni antigen Hep Par 1 je u većini tumora bio pozitivan sa značajno smanjenim intenzitetom reakcije u usporedbi s normalnim hepatocitima, dok je CK19 specifičan za bilijarni epitel bio negativan. Rezultati istraživanja ukazuju na značenje TGFb-r u nastanku HCC u pasa i istodobno naglašavaju njegovo značenje u ovom tumoru ljudi.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCollegium Antropologicum
Numberingvol. 33, no. 3, pp. 811-814
p-ISSN0350-6134
URN:NBNurn:nbn:hr:105:554314
Publication2009-09
Document URLhttps://hrcak.srce.hr/41823
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 11:27:41