prikaz prve stranice dokumenta Alterations of FHIT and P53 genes in keratocystic odontogenic tumor, dentigerous and radicular cyst
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Scientific paper - Original scientific paper
Alterations of FHIT and P53 genes in keratocystic odontogenic tumor, dentigerous and radicular cyst
Journal of Oral Pathology & Medicine, 37 (2008), 5; 294-301. https://doi.org/10.1111/j.1600-0714.2007.00622.x
Malčić, Ana; Jukić, Silvana; Anić, Ivica; Pavelić, Božidar; Kapitanović, Sanja; Krušlin, Božo; Pavelić, Krešimir

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Malčić, A., Jukić, S., Anić, I., Pavelić, B., Kapitanović, S., Krušlin, B. & Pavelić, K. (2008). Alterations of FHIT and P53 genes in keratocystic odontogenic tumor, dentigerous and radicular cyst. Journal of Oral Pathology & Medicine, 37. (5), 294-301. doi: 10.1111/j.1600-0714.2007.00622.x

Malčić, Ana, et al. "Alterations of FHIT and P53 genes in keratocystic odontogenic tumor, dentigerous and radicular cyst." Journal of Oral Pathology & Medicine, vol. 37, no. 5, 2008, pp. 294-301. https://doi.org/10.1111/j.1600-0714.2007.00622.x

Malčić, Ana, Silvana Jukić, Ivica Anić, Božidar Pavelić, Sanja Kapitanović, Božo Krušlin and Krešimir Pavelić. "Alterations of FHIT and P53 genes in keratocystic odontogenic tumor, dentigerous and radicular cyst." Journal of Oral Pathology & Medicine 37, no. 5 (2008): 294-301. https://doi.org/10.1111/j.1600-0714.2007.00622.x

Malčić, A., et al. (2008) 'Alterations of FHIT and P53 genes in keratocystic odontogenic tumor, dentigerous and radicular cyst', Journal of Oral Pathology & Medicine, 37(5), pp. 294-301. doi: 10.1111/j.1600-0714.2007.00622.x

Malčić A, Jukić S, Anić I, Pavelić B, Kapitanović S, Krušlin B, and sur.. Alterations of FHIT and P53 genes in keratocystic odontogenic tumor, dentigerous and radicular cyst. Journal of Oral Pathology & Medicine [Internet]. 2008 May [cited 2024 May 05];37(5):294-301. doi: 10.1111/j.1600-0714.2007.00622.x

A. Malčić, et al., "Alterations of FHIT and P53 genes in keratocystic odontogenic tumor, dentigerous and radicular cyst", Journal of Oral Pathology & Medicine, vol. 37, no. 5, pp. 294-301, May 2008. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:443461. [Accessed: 05 May 2024]

Metadata
Title (english)Alterations of FHIT and P53 genes in keratocystic odontogenic tumor, dentigerous and radicular cyst
AuthorAna Malčić
AuthorSilvana Jukić
AuthorIvica Anić
AuthorBožidar Pavelić
AuthorSanja Kapitanović
AuthorBožo Krušlin
AuthorKrešimir Pavelić
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
BACKGROUND: The purpose of this study was to determine fragile histidine triad (FHIT) and p53 protein expression, and to analyze FHIT and p53 gene status in keratocystic odontogenic tumor (KOT), dentigerous cysts (DC) and radicular cysts (RC). ----- METHODS: The methods used were immunohistochemistry and molecular genetic methods including loss of heterozygosity (LOH) and gene sequencing. ----- RESULTS: FHIT protein expression was different among groups. Aberrant expression was the highest in KOT, then in RC and DC. p53 protein expression was different among groups. LOH in paraffin-embedded specimens was detected in 22.6% and 12.9% for FHIT and p53 respectively. Mutation of p53 gene at codon 237 was observed in only two specimens (one KOT and one DC). Of the six frozen specimens, three exhibited FHIT gene LOH (two RC and one KOT). KOT showed loss of exons 6-7 at FHIT locus and mutation at codon 237 at p53 locus, but this could be a chance result. ----- CONCLUSION: Aberrations of FHIT and p53 genes/proteins could be considered markers responsible for the development of odontogenic lesions.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleJournal of Oral Pathology & Medicine
Numberingvol. 37, no. 5, pp. 294-301
p-ISSN0904-2512
DOIhttps://doi.org/10.1111/j.1600-0714.2007.00622.x
URN:NBNurn:nbn:hr:105:443461
Publication2008-05
Document URLhttps://doi.org/10.1111/j.1600-0714.2007.00622.x
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 11:35:01