prikaz prve stranice dokumenta Parvovirus B 19 (PVB19) induced pure red cell aplasia (PRCA) in immunocompromised patient after liver transplantation
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Scientific paper - Case study
Parvovirus B 19 (PVB19) induced pure red cell aplasia (PRCA) in immunocompromised patient after liver transplantation
Collegium Antropologicum, 34 (2010), 1; 271-274. urn:nbn:hr:105:082433
Mrzljak, Anna; Kardum-Skelin, Ika; Čolić Cvrlje, Vesna; Filipec Kanižaj, Tajana; Šušterčić, Dunja; Guštin, Denis; Kocman, Branislav

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Mrzljak, A., Kardum Skelin, I., Čolić Cvrlje, V., Filipec Kanižaj, T., Šušterčić, D., Guštin, D. & Kocman, B. (2010). Parvovirus B 19 (PVB19) induced pure red cell aplasia (PRCA) in immunocompromised patient after liver transplantation . Collegium Antropologicum, 34. (1), 271-274. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:082433

Mrzljak, Anna, et al. "Parvovirus B 19 (PVB19) induced pure red cell aplasia (PRCA) in immunocompromised patient after liver transplantation ." Collegium Antropologicum, vol. 34, no. 1, 2010, pp. 271-274. https://urn.nsk.hr/urn:nbn:hr:105:082433

Mrzljak, Anna, Ika Kardum Skelin, Vesna Čolić Cvrlje, Tajana Filipec Kanižaj, Dunja Šušterčić, Denis Guštin and Branislav Kocman. "Parvovirus B 19 (PVB19) induced pure red cell aplasia (PRCA) in immunocompromised patient after liver transplantation ." Collegium Antropologicum 34, no. 1 (2010): 271-274. https://urn.nsk.hr/urn:nbn:hr:105:082433

Mrzljak, A., et al. (2010) 'Parvovirus B 19 (PVB19) induced pure red cell aplasia (PRCA) in immunocompromised patient after liver transplantation ', Collegium Antropologicum, 34(1), pp. 271-274. Available at: https://urn.nsk.hr/urn:nbn:hr:105:082433 (Accessed 27 December 2024)

Mrzljak A, Kardum Skelin I, Čolić Cvrlje V, Filipec Kanižaj T, Šušterčić D, Guštin D, and sur.. Parvovirus B 19 (PVB19) induced pure red cell aplasia (PRCA) in immunocompromised patient after liver transplantation . Collegium Antropologicum [Internet]. 2010 March [cited 2024 December 27];34(1):271-274. Available at: https://urn.nsk.hr/urn:nbn:hr:105:082433

A. Mrzljak, et al., "Parvovirus B 19 (PVB19) induced pure red cell aplasia (PRCA) in immunocompromised patient after liver transplantation ", Collegium Antropologicum, vol. 34, no. 1, pp. 271-274, March 2010. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:082433. [Accessed: 27 December 2024]

Metadata
Title (english)Parvovirus B 19 (PVB19) induced pure red cell aplasia (PRCA) in immunocompromised patient after liver transplantation
Title (croatian)Izolirana aplazija crvene krvne loze uzrokovana infekcijom Parvovirusom B 19 nakon transplantacije jetre
AuthorAnna Mrzljak
AuthorIka Kardum-Skelin
AuthorVesna Čolić Cvrlje
AuthorTajana Filipec Kanižaj
AuthorDunja Šušterčić
AuthorDenis Guštin
AuthorBranislav Kocman
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Presented here is a case of human parvovirus B19 (PVB19) induced pure red-cell aplasia (PRCA) in immunocompromised patient after orthotopic liver transplantation (OLT). PVB19 is a small, single-stranded DNA whose target cell is the erythroid progenitor in bone marrow. Manifestations of PVB19 infection vary with the immunologic status of the patient, ranging from asymptomatic to severe infections and PRCA. Post-transplant PRCA is induced either by immunosuppressive agents or PVB19. In the presented case, bone marrow aspiration characterized by the absence of mature erythroid precursors and detection of PVB19 DNA in blood led to treatment with high-dose intravenous human immunoglobulins (IVIG) and subsequent recovery of erythropoiesis. Due to insufficient antibody response in immunocompromised patients, suppression of the PVB19 infection is delayed and repetitive treatments may be administrated in attempt of reversing PRCA.
Abstract (croatian)
Prikazujemo slučaj izolirane aplazije crvene krvne loze uzrokovane humanim parvovirus B19 (PVB19) kod imunokompromitiranog bolesnika nakon transplantacije jetre. PVB19 je malen, jednolančani DNA virus čije je djelovanje usmjereno na prekursorne eritoidne stanice u koštanoj srži. Manifestacije PVB19 infekcije su raznolike, te ovise o imunološkom statusu bolesnika, a prezentiraju u rasponu od asimptomatskih do teških infekcija i izolirane aplazije crvene krvne loze. Kod transplantiranih bolesnika uzrok izolirane aplazije crvene krvne loze su imunosupresivni lijekovi ili PVB19. U prikazanom slučaju temeljem citološke analize koštane srži uz karakteristični nedostatak zrelih eritoidnih prekursora te verifikacijom PVB19 DNA u krvi postavljena je dijagnoza. Bolesnik je liječen visokim dozama intravenskih ljudskih imunoglobulina što je dovelo do oporavka eritropoeze. Međutim kod transplantiranih bolesnika, radi imunosupresivne terapije postoji nedostatan imunološki odgovor stoga je supresija infekcije PVB19 odgođena što zahtjeva ustrajnost u terapiji u cilju pokušaja reverzije izolirane aplazije crvene krvne loze.
Keywords (english)
Languageenglish
Publication typeScientific paper - Case study
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCollegium Antropologicum
Numberingvol. 34, no. 1, pp. 271-274
p-ISSN0350-6134
URN:NBNurn:nbn:hr:105:082433
Publication2010-03
Document URLhttps://hrcak.srce.hr/51277
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 11:40:59