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Scientific paper - Original scientific paper
Biliary brush cytology for the diagnosis of malignancy: a single center experience
Collegium Antropologicum, 34 (2010), 1; 139-143. urn:nbn:hr:105:264424
Štoos-Veić, Tajana; Bilić, Branko; Kaić, Gordana; Trutin Ostović, Karmen; Babić, Žarko; Kujundžić, Milan

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Štoos Veić, T., Bilić, B., Kaić, G., Trutin Ostović, K., Babić, Ž. & Kujundžić, M. (2010). Biliary brush cytology for the diagnosis of malignancy: a single center experience . Collegium Antropologicum, 34. (1), 139-143. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:264424

Štoos Veić, Tajana, et al. "Biliary brush cytology for the diagnosis of malignancy: a single center experience ." Collegium Antropologicum, vol. 34, no. 1, 2010, pp. 139-143. https://urn.nsk.hr/urn:nbn:hr:105:264424

Štoos Veić, Tajana, Branko Bilić, Gordana Kaić, Karmen Trutin Ostović, Žarko Babić and Milan Kujundžić. "Biliary brush cytology for the diagnosis of malignancy: a single center experience ." Collegium Antropologicum 34, no. 1 (2010): 139-143. https://urn.nsk.hr/urn:nbn:hr:105:264424

Štoos Veić, T., et al. (2010) 'Biliary brush cytology for the diagnosis of malignancy: a single center experience ', Collegium Antropologicum, 34(1), pp. 139-143. Available at: https://urn.nsk.hr/urn:nbn:hr:105:264424 (Accessed 02 May 2024)

Štoos Veić T, Bilić B, Kaić G, Trutin Ostović K, Babić Ž, Kujundžić M. Biliary brush cytology for the diagnosis of malignancy: a single center experience . Collegium Antropologicum [Internet]. 2010 March [cited 2024 May 02];34(1):139-143. Available at: https://urn.nsk.hr/urn:nbn:hr:105:264424

T. Štoos Veić, B. Bilić, G. Kaić, K. Trutin Ostović, Ž. Babić and M. Kujundžić, "Biliary brush cytology for the diagnosis of malignancy: a single center experience ", Collegium Antropologicum, vol. 34, no. 1, pp. 139-143, March 2010. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:264424. [Accessed: 02 May 2024]

Metadata
Title (english)Biliary brush cytology for the diagnosis of malignancy: a single center experience
Title (croatian)Citološki razmazi brisa četkicom u dijagnostici malignih promjena bilijarnog stabla: naše iskustvo
AuthorTajana Štoos-Veić
AuthorBranko Bilić
AuthorGordana Kaić
AuthorKarmen Trutin Ostović
AuthorŽarko Babić
AuthorMilan Kujundžić
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Differentiation between benign and malignant biliary strictures is critical to the provision of adequate treatment. Brush cytology during the endoscopic retrograde cholangiopancreatography (ERCP) is the most commonly used method for obtaining tissue confirmation of the nature of biliary strictures. It’s specificity is remarkably high but reported sensitivities for the diagnosis of malignancy are low. Aim of our study was to assess sensitivity and specificity of biliary brush cytology in our institution, to find out main causes of false negative diagnoses and to confirm impression that the team approach has impact on sensitivity. Gold standard for diagnosis was definitive surgical histology or adequate clinical follow up for minimum of six month. Direct smears made by cytotechnician at the endoscopy room, and stained according to Papanicolaou and May-Grünwald Giemsa (MGG) were examined for well-recognized features of malignancy on conventional smears as a part of diagnostic routine. Cytologic diagnoses were benign, atypical/reactive, suspicious for malignancy and malignant. Of 143 brushings with available definitive diagnosis 36 (25%) had malignant cytologic diagnosis and 91(63.6%) were classified as benign, 3 were atypical/reactive and 13 suspicious for malignancy with 20 »false-negative« cases. When specimens with atypical and suspicious cytology were excluded from data analysis sensitivity was 64% and specificity was 100% and when suspicious findings were taken into account as true positives sensitivity rose to 71%. We find that biliary brush cytology, although mainly depending on the skill of endoscopist, as well as the experience of the cytologist, is a valuable method for obtaining accurate tissue diagnosis of biliary strictures, thus solving eternal diagnostic dilemma: benign or malignant.
Abstract (croatian)
Preoperativno razlikovanje malignih od benignih suženja bilijarnog stabla usprkos novim dijagnostičkim mogućnostima još uvijek predstavlja izazov, a važnost tkivne dijagnoze je neupitna za izbor odgovarajućeg postupka liječenja. Razmaz brisa četkicom pri endoskopskoj retrogradnoj kolangiopankreatografiji (ERCP) i citološka analiza uzorka je danas uobičajena metoda za dobivanje tkivne dijagnoze. Dosadašnje studije su pokazale da je metoda visoko specifična ali uglavnom slabo osjetljiva zbog velikog broja lažno negativnih citoloških dijagnoza. Cilj ovog rada je bio provjeriti osjetljivost i specifičnost metode u našoj ustanovi, pronaći glavne uzroke lažno negativnih citoloških nalaza te potvrditi utjecaj timskog pristupa na citološku dijagnozu. Zlatni standard za dijagnozu bio je histološki nalaz ili klinički ishod utvrđen praćenjem najmanje šest mjeseci. Svi su razmazi napravljeni metodom direktnog nanošnja materijala sa četkice na staklo odmah po uzimanju uzorka u sobi za endoskopiju uz prisustvo citotehničara. Dio razmaza je odmah fiksiran u etanolu i bojan po Papanicolaou a dio sušen na zraku i bojan metodom po May-Grünwald Giemsi (MGG). Razmazi su rutinski analizirani i ocijenjeni kao benigni, atipični/reaktivni, suspektni i maligni. Od 143 uzorka s poznatim konačnim ishodom njih 36 (25%) je citološki ocijenjeno malignim, 91 (63.6%) uzorak je bio benigan, uz 3 atipična i 13 suspektnih. Konačna maligna dijagnoza je postavljena u 20 od 91 citološki benignog uzorka. Isljučivši uzorke s atipičnim i suspektnim citološkim nalazom iz analize, osjetljivost metode iznosi 64% uz uobičajeno visoku specifičnost od 100%. Stavivši suspektne i pozitivne citološke nalaze u jednu kategoriju kako je uobičajeno, osjetljivost je narasla na 71%. Iako ovisi o vještini endoskopičara i iskustvu citologa možemo slobodno zaključiti da je citološka analiza razmaza brisa četkicom pri ERCP-u vrijedna metoda za dobivanje pouzdane tkivne dijagnoze.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCollegium Antropologicum
Numberingvol. 34, no. 1, pp. 139-143
p-ISSN0350-6134
URN:NBNurn:nbn:hr:105:264424
Publication2010-03
Document URLhttps://hrcak.srce.hr/51254
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 11:41:47