prikaz prve stranice dokumenta Effects of high sucrose diet, gemfibrozil, and their combination on plasma paraoxonase 1 activity and lipid levels in rats
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Scientific paper - Original scientific paper
Effects of high sucrose diet, gemfibrozil, and their combination on plasma paraoxonase 1 activity and lipid levels in rats
Acta Biochimica Polonica, 57 (2010), 3; 321-326. urn:nbn:hr:105:363656
Macan, Marija; Vrkić, Nada; Lucić Vrdoljak, Ana; Radić, Božica; Bradamante, Vlasta

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Macan, M., Vrkić, N., Lucić Vrdoljak, A., Radić, B. & Bradamante, V. (2010). Effects of high sucrose diet, gemfibrozil, and their combination on plasma paraoxonase 1 activity and lipid levels in rats. Acta Biochimica Polonica, 57. (3), 321-326. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:363656

Macan, Marija, et al. "Effects of high sucrose diet, gemfibrozil, and their combination on plasma paraoxonase 1 activity and lipid levels in rats." Acta Biochimica Polonica, vol. 57, no. 3, 2010, pp. 321-326. https://urn.nsk.hr/urn:nbn:hr:105:363656

Macan, Marija, Nada Vrkić, Ana Lucić Vrdoljak, Božica Radić and Vlasta Bradamante. "Effects of high sucrose diet, gemfibrozil, and their combination on plasma paraoxonase 1 activity and lipid levels in rats." Acta Biochimica Polonica 57, no. 3 (2010): 321-326. https://urn.nsk.hr/urn:nbn:hr:105:363656

Macan, M., et al. (2010) 'Effects of high sucrose diet, gemfibrozil, and their combination on plasma paraoxonase 1 activity and lipid levels in rats', Acta Biochimica Polonica, 57(3), pp. 321-326. Available at: https://urn.nsk.hr/urn:nbn:hr:105:363656 (Accessed 02 May 2024)

Macan M, Vrkić N, Lucić Vrdoljak A, Radić B, Bradamante V. Effects of high sucrose diet, gemfibrozil, and their combination on plasma paraoxonase 1 activity and lipid levels in rats. Acta Biochimica Polonica [Internet]. 2010 June 11 [cited 2024 May 02];57(3):321-326. Available at: https://urn.nsk.hr/urn:nbn:hr:105:363656

M. Macan, N. Vrkić, A. Lucić Vrdoljak, B. Radić and V. Bradamante, "Effects of high sucrose diet, gemfibrozil, and their combination on plasma paraoxonase 1 activity and lipid levels in rats", Acta Biochimica Polonica, vol. 57, no. 3, pp. 321-326, June 2010. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:363656. [Accessed: 02 May 2024]

Metadata
Title (english)Effects of high sucrose diet, gemfibrozil, and their combination on plasma paraoxonase 1 activity and lipid levels in rats
AuthorMarija Macan
AuthorNada Vrkić
AuthorAna Lucić Vrdoljak
AuthorBožica Radić
AuthorVlasta Bradamante
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
We investigated the influence of high sucrose diet (HSD) after 3 or 5 weeks of administration on paraoxonase 1 (PON1) activity in plasma of normolipidemic rats and the relationship between serum PON1 activity, triacylglycerides (TGs), HDL and total cholesterol vs. the control group of rats fed normal, control diet (CD). Because the data about the influence of gemfibrozil (GEM) on PON1 activity are controversial, we also investigated its effects (administration in the 4th and 5th week in rats on HSD and CD) on plasma PON1 activity and lipid levels in normolipidemic rats, and in rats with hypertriglyceridemia caused by HSD. Our results obtained in rats on HSD show a significant increase of plasma TGs levels by 47% (P<0.05) after 5 weeks of treatment, and PON1 activity by 32% and 23% (P<0.05) after 3 and 5 weeks, but without change in lipid levels vs. rats on CD. In the rats on CD and HSD, GEM caused a significant decrease of PON1 activity by 44% and 33%, while a significant decrease of TGs level by 38% (P<0.05) was measured only in rats on CD. The effects of GEM on total cholesterol, HDL and LDL in both groups of rats were typical for its action on lipoprotein metabolism. Because GEM in the rat liver stimulates proliferation of peroxisomes, β oxidation, and production of H2O2, it is possible that the oxidative stress induced by GEM damages hepatocytes and lowers the synthesis of PON1.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleActa Biochimica Polonica
Numberingvol. 57, no. 3, pp. 321-326
p-ISSN0001-527X
URN:NBNurn:nbn:hr:105:363656
Publication2010-06-11
Document URLhttp://www.actabp.pl/pdf/3_2010/321.pdf
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 11:50:27