Cardiovascular diseases are the leading cause of death worldwide. Traditional cardiovascular risk factors include age, gender, smoking, hypertension, hypercholesterolemia and diabetes. Cardiovascular risk in patients with systemic lupus erythematosus and rheumatoid arthritis refers to early atherosclerosis, can not be explained by traditional CV risk. Patients with SLE have a 5-8 times higher incidence of coronary heart disease than the general population, which is associated with dyslipidemia, the presence of LDL-phenotype B and simultaneously present systemic inflammation. Premature atherosclerosis in these patients is the result of traditional KVR factors, factors specific to autoimmune disease and inflammatory mediators. Since the CVD are leading cause of death raises the question increasingly on preventive cardiology treatment. If kidey failure is developed situation becomes even more serious.Renal changes in RA and SLE are common, while in other autoimmune diseases Chronic kidney disease is a major public health problem. Defined as the presence of kidney damage or decreased kidney function over a period of 3 months or longer. In chronic renal disease all renal functions are damaged: excretion rates, endocrine and metabolic function. The beginning is slow and mostly unrecognized as an aggravating circumstance as part of the failure of preventive measures lies in the late such as scleroderma and psoriasis are rarely found. All patients with RA should monitor renal function with the determination of creatinine clearance, urine sediment examination and 24 h proteinuria. detection of chronic kidney disease,when the possibilities of action are small, which is further complicated in patients with autoimmune diseases.