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Scientific paper - Original scientific paper
Thrombotic thrombocytopenic purpura: the role of ADAMTS13 assay in clinical practice
Collegium Antropologicum, 34 (2010), 3; 1087-1091. urn:nbn:hr:105:116100
Duraković, Nadira; Radonić, Radovan; Gašparović, Vladimir

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Duraković, N., Radonić, R. & Gašparović, V. (2010). Thrombotic thrombocytopenic purpura: the role of ADAMTS13 assay in clinical practice . Collegium Antropologicum, 34. (3), 1087-1091. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:116100

Duraković, Nadira, et al. "Thrombotic thrombocytopenic purpura: the role of ADAMTS13 assay in clinical practice ." Collegium Antropologicum, vol. 34, no. 3, 2010, pp. 1087-1091. https://urn.nsk.hr/urn:nbn:hr:105:116100

Duraković, Nadira, Radovan Radonić and Vladimir Gašparović. "Thrombotic thrombocytopenic purpura: the role of ADAMTS13 assay in clinical practice ." Collegium Antropologicum 34, no. 3 (2010): 1087-1091. https://urn.nsk.hr/urn:nbn:hr:105:116100

Duraković, N., Radonić, R. and Gašparović, V. (2010) 'Thrombotic thrombocytopenic purpura: the role of ADAMTS13 assay in clinical practice ', Collegium Antropologicum, 34(3), pp. 1087-1091. Available at: https://urn.nsk.hr/urn:nbn:hr:105:116100 (Accessed 06 May 2024)

Duraković N, Radonić R, Gašparović V. Thrombotic thrombocytopenic purpura: the role of ADAMTS13 assay in clinical practice . Collegium Antropologicum [Internet]. 2010 September [cited 2024 May 06];34(3):1087-1091. Available at: https://urn.nsk.hr/urn:nbn:hr:105:116100

N. Duraković, R. Radonić and V. Gašparović, "Thrombotic thrombocytopenic purpura: the role of ADAMTS13 assay in clinical practice ", Collegium Antropologicum, vol. 34, no. 3, pp. 1087-1091, September 2010. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:116100. [Accessed: 06 May 2024]

Metadata
Title (english)Thrombotic thrombocytopenic purpura: the role of ADAMTS13 assay in clinical practice
Title (croatian)Trombotak trombocitopenična purpura: uloga testa ADAMTS13 proteaze u kliničkoj praksi
AuthorNadira Duraković
AuthorRadovan Radonić
AuthorVladimir Gašparović
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Thrombotic thrombocytopenic purpura (TTP) is a disorder characterized by disseminated thrombotic occlusions of the microcirculation. Identification of ADAMTS13 protease and its place in the pathophysiology of TTP led to better understanding of the disease and better survival for the diseased. Here we show a case report of a patient that had a normal ADAMTS13protease activity and an unusual clinical presentation and utilize that case to highlight how the absence of a severe ADAMTS13 protease deficiency does not preclude a diagnosis of TTP and how early initiation and continuation of plasma exchange therapy can lead to a positive outcome, even in a severely ill patient. Even though ADAMTS13 protease determination has no immediate influence on the decision whether or not to start the plasma exchange therapy, it has great impact on future management of the patient and should be determined whenever possible.
Abstract (croatian)
Trombotska trombocitopenična purpura (TTP) je bolest karakterizirana diseminiranim trombotskim okluzijama mikrocirkulacije. Identifikacija ADAMTS13 proteaze i njenog mjesta u patofiziologiji bolesti dovelo je do boljeg razumijevanja bolesti i boljeg preživljenja oboljelih. Ovaj rad je prikaz slučaja bolesnica s normalnom razinom ADAMTS13 aktivnosti i neobičnom kliničkom prezentacijom uz pomoć kojega želimo naglasiti kako odsustvo teškog pomanjkanja ADAMTS13 aktivnosti ne izuzima dijagnozu TTP i kako rano započinjanje i nastavak terapije izmjenom plazme može dovesti do pozitivnog ishoda, čak i u teško oboljelih. Iako određivanje nedostatka ADAMTS13 aktivnosti nema trenutni utjecaj na odluku da li ili ne započeti terapiju izmjenom plazme, ima veliki utjecaj na daljnje terapijske odluke i trebala bi biti pokušana kad god je to moguće.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCollegium Antropologicum
Numberingvol. 34, no. 3, pp. 1087-1091
p-ISSN0350-6134
URN:NBNurn:nbn:hr:105:116100
Publication2010-09
Document URLhttps://hrcak.srce.hr/59380
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 11:55:30