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Scientific paper - Original scientific paper
Changes in brain metabolites measured with magnetic resonance spectroscopy in antidepressant responders with comorbid major depression and posttraumatic stress disorder
Collegium Antropologicum, 35 (2011), S. 1; 145-148. urn:nbn:hr:105:135308
Henigsberg, Neven; Bajs, Maja; Hrabač, Pero; Kalember, Petra; Radoš, Marko; Radoš, Milan; Radonić, Elizabeta

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Henigsberg, N., Bajs, M., Hrabač, P., Kalember, P., Radoš, M., Radoš, M. & Radonić, E. (2011). Changes in brain metabolites measured with magnetic resonance spectroscopy in antidepressant responders with comorbid major depression and posttraumatic stress disorder . Collegium Antropologicum, 35. (S. 1), 145-148. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:135308

Henigsberg, Neven, et al. "Changes in brain metabolites measured with magnetic resonance spectroscopy in antidepressant responders with comorbid major depression and posttraumatic stress disorder ." Collegium Antropologicum, vol. 35, no. S. 1, 2011, pp. 145-148. https://urn.nsk.hr/urn:nbn:hr:105:135308

Henigsberg, Neven, Maja Bajs, Pero Hrabač, Petra Kalember, Marko Radoš, Milan Radoš and Elizabeta Radonić. "Changes in brain metabolites measured with magnetic resonance spectroscopy in antidepressant responders with comorbid major depression and posttraumatic stress disorder ." Collegium Antropologicum 35, no. S. 1 (2011): 145-148. https://urn.nsk.hr/urn:nbn:hr:105:135308

Henigsberg, N., et al. (2011) 'Changes in brain metabolites measured with magnetic resonance spectroscopy in antidepressant responders with comorbid major depression and posttraumatic stress disorder ', Collegium Antropologicum, 35(S. 1), pp. 145-148. Available at: https://urn.nsk.hr/urn:nbn:hr:105:135308 (Accessed 18 February 2025)

Henigsberg N, Bajs M, Hrabač P, Kalember P, Radoš M, Radoš M, and sur.. Changes in brain metabolites measured with magnetic resonance spectroscopy in antidepressant responders with comorbid major depression and posttraumatic stress disorder . Collegium Antropologicum [Internet]. 2011 January [cited 2025 February 18];35(S. 1):145-148. Available at: https://urn.nsk.hr/urn:nbn:hr:105:135308

N. Henigsberg, et al., "Changes in brain metabolites measured with magnetic resonance spectroscopy in antidepressant responders with comorbid major depression and posttraumatic stress disorder ", Collegium Antropologicum, vol. 35, no. S. 1, pp. 145-148, January 2011. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:135308. [Accessed: 18 February 2025]

Metadata
Title (english)Changes in brain metabolites measured with magnetic resonance spectroscopy in antidepressant responders with comorbid major depression and posttraumatic stress disorder
Title (croatian)Promjene razina moždanih metabolita mjerenih magnetskom rezonantnom spektroskopijom u ispitanika s komorbiditetom depresije i posttraumatskog stresnog poremećaja koji su odgovorili na antidepresivno liječenje
AuthorNeven Henigsberg
AuthorMaja Bajs
AuthorPero Hrabač
AuthorPetra Kalember
AuthorMarko Radoš
AuthorMilan Radoš
AuthorElizabeta Radonić
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
In a present pilot study, performed on 11 subjects, we studied proton magnetic resonance spectroscopy (1H-MRS) changes in early to intermediate (3-6 weeks) responders to antidepressant treatment with selective serotonin reuptake inhibitors (SSRIs). All subjects had diagnosis of major recurrent depression comorbid to posttraumatic stress disorder (PTSD). Magnetic spectroscopy was done in the region of dorsolateral prefrontal cortex on a 3T MRI-unit. Participants were selected out of the larger sample due to an early response to antidepressant treatment within 3–6 weeks, measured with Beck Depression Inventory (BDI). We measured levels of neuronal marker N-acetyl-aspartate (NAA), choline (CHO) and creatine (Cr). There was no difference in NAA/Cr ratios between the first and the second spectroscopic scans (p=0.751). However, CHO/Cr ratios showed increasing trend with mean value at the first scan of 1.09 (SD=0.22) while mean value at second scan was 1.25 (SD=0.24), displaying statically significant difference (p=0.015). In conclusion, significant increase in choline to creatine ratio from the first to the second spectroscopic scan during the antidepressant treatment, compared to almost identical values of NAA to creatine ratio, suggests increased turnover of cell membranes as a mechanism of the early response to the antidepressant drug therapy.
Abstract (croatian)
U ovom pilot-ispitivanju, provedenom na 11 ispitanika, koristili smo metodu protonske magnentno rezonantne spektroskopije (1H-MRS) kako bismo prikazali promjene u osoba koje su imale pozitivan rani odgovor (3–6 tjedana) na antidepresivno liječenje selektivnim inhibitorima ponovne pohrane serotonina (SSRI). Svi ispitanici imali su dijagnozu teške rekurentne depresije u komorbiditetu s posttraumatskim stresnim poremećajem (PTSP). Magnetskom spektroskopijom na uređaju od 3T promatrano je područje dorzolateralnog prefrontalnog korteksa. Iz većeg uzorka izabrani su oni ispitanici koji su pokazali rani odgovor na antidepresivno liječenje tijekom 3–6 tjedana, mjereno ljestvicom Beck Depression Inventory (BDI). Metodom 1H-MRS mjerene su razine neuronskog markera N-acetil-aspartata (NAA), kolina (CHO) i kretina (Cr). Između prvog i drugog spektroskopskog mjerenja nije bilo značajnih razlika u omjeru NAA/Cr (p=0,751). S druge strane, omjeri CHO/Cr pokazali su tendenciju povećanja sa srednjom vrijednosti na prvom mjerenju od 1,09 (SD=0,22), dok je srednja vrijednost na drugom mjerenju iznosila 1,25 (SD=0,24), što je rezultiralo statistički značajnom razlikom (p=0,015). Značajno povećanje omjera kolina prema kreatinu od prvog do drugog spektroskopskog mjerenja, tijekom antidepresivnog liječenja, u usporedbi s gotovo identičnim vrijednostima omjera NAA prema kreatinu, sugerira da bi za mehanizam ranog odgovora na liječenje antidepresivnim lijekovima mogao biti odgovorno pojačano prepravljanje staničnih membrana.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCollegium Antropologicum
Numberingvol. 35, no. S. 1, pp. 145-148
p-ISSN0350-6134
URN:NBNurn:nbn:hr:105:135308
Publication2011-01
Document URLhttps://hrcak.srce.hr/64061
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 12:01:18