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Scientific paper - Original scientific paper
Comparison of hippocampal volumes in schizophrenia, schizoaffective and bipolar disorder
Collegium Antropologicum, 35 (2011), S. 1; 249-252. urn:nbn:hr:105:158081
Radonić, Elizabeta; Radoš, Marko; Kalember, Petra; Bajs-Janović, Maja; Folnegović-Šmalc, Vera; Henigsberg, Neven

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Radonić, E., Radoš, M., Kalember, P., Bajs Janović, M., Folnegović Šmalc, V. & Henigsberg, N. (2011). Comparison of hippocampal volumes in schizophrenia, schizoaffective and bipolar disorder . Collegium Antropologicum, 35. (S. 1), 249-252. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:158081

Radonić, Elizabeta, et al. "Comparison of hippocampal volumes in schizophrenia, schizoaffective and bipolar disorder ." Collegium Antropologicum, vol. 35, no. S. 1, 2011, pp. 249-252. https://urn.nsk.hr/urn:nbn:hr:105:158081

Radonić, Elizabeta, Marko Radoš, Petra Kalember, Maja Bajs Janović, Vera Folnegović Šmalc and Neven Henigsberg. "Comparison of hippocampal volumes in schizophrenia, schizoaffective and bipolar disorder ." Collegium Antropologicum 35, no. S. 1 (2011): 249-252. https://urn.nsk.hr/urn:nbn:hr:105:158081

Radonić, E., et al. (2011) 'Comparison of hippocampal volumes in schizophrenia, schizoaffective and bipolar disorder ', Collegium Antropologicum, 35(S. 1), pp. 249-252. Available at: https://urn.nsk.hr/urn:nbn:hr:105:158081 (Accessed 11 July 2024)

Radonić E, Radoš M, Kalember P, Bajs Janović M, Folnegović Šmalc V, Henigsberg N. Comparison of hippocampal volumes in schizophrenia, schizoaffective and bipolar disorder . Collegium Antropologicum [Internet]. 2011 January [cited 2024 July 11];35(S. 1):249-252. Available at: https://urn.nsk.hr/urn:nbn:hr:105:158081

E. Radonić, M. Radoš, P. Kalember, M. Bajs Janović, V. Folnegović Šmalc and N. Henigsberg, "Comparison of hippocampal volumes in schizophrenia, schizoaffective and bipolar disorder ", Collegium Antropologicum, vol. 35, no. S. 1, pp. 249-252, January 2011. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:158081. [Accessed: 11 July 2024]

Metadata
Title (english)Comparison of hippocampal volumes in schizophrenia, schizoaffective and bipolar disorder
Title (croatian)Usporedba volumena hipokampusa u shizofreniji, shizoafektivnom i bipolarnom poremećaju
AuthorElizabeta Radonić
AuthorMarko Radoš
AuthorPetra Kalember
AuthorMaja Bajs-Janović
AuthorVera Folnegović-Šmalc
AuthorNeven Henigsberg
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
The reduction of hippocampal volume was frequently reported in schizophrenia, but not in bipolar disorder. This volume reduction is associated with clinical features of schizophrenia, in particular with working and verbal memory impairments. Schizoaffective disorder, as a specific disorder sharing clinical features of both schizophrenia and bipolar disorder is rarely analyzed as a separate disorder in neurobiological studies. The aim of this study was to compare hippocampal volumes in separate groups of patients with schizophrenia, schizoaffective and bipolar disorder. Hippocampal volumes were estimated using high resolution magnetic resonance imaging in 60 subjects, 15 subjects in each patient and one healthy volunteer (control) group. There were no significant differences in hippocampal volume between bipolar disorder and control group. Hippocampal volume was statistically significantly reduced in the group of patients with schizophrenia and schizoaffective disorder, compared to either bipolar disorder or control group, thus supporting the hypothesis that hippocampal volume reduction could be considered as a possible neurobiological basis for clinical aspects of schizophrenia and schizoaffective disorder associated with working and verbal memory impairment.
Abstract (croatian)
Smanjenje volumena hipokampusa čest je nalaz u shizofreniji, ali ne i u bipolarnom poremećaju. Ovo smanjenje volumena povezano je s kliničkim obilježjima shizofrenije, posebice oštećenjima radnog i verbalnog pamćenja. Shizoafektivni poremećaj, specifični poremećaj u kojem se ispoljavaju klinička obilježja i shizofrenije i bipolarnog poremećaja, rijetko se analizira kao zasebni poremećaj u neurobiološkim istraživanjima uopće. Cilj ovog istraživanja bio je usporediti volumen hipokampusa u zasebnim skupinama pacijenata sa shizofrenijom, shizoafektivnim i bipolarnim poremećajem. Za mjerenje volumena hipokampusa rabljena je metoda oslikavanja mozga magnetskom rezonancijom visoke rezolucije na 60 ispitanika, po 15 u svakoj skupini oboljelih kao i u skupini duševno zdravih dobrovoljaca (kontrolna skupina). Nema statistički značajnih razlika u volumenu hipokampusa između pacijenata s bipolarnim poremećajem i kontrolne skupine. Volumen hipokampusa statistički je značajno smanjen u skupinama pacijenata sa shizofrenijom odnosno sa shizoafektivnim poremećajem, o odnosu na skupinu s bipolarnim poremećajem kao i na kontrolnu skupinu. Ovaj rezultat podržava pretpostavku da smanjenje volumena hipokampusa može predstavljati neurobiološku podlogu kliničkih obilježja shizofrenije i shizoafektivnog poremećaja povezanih s oštećenjima radnog i verbalnog pamćenja.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCollegium Antropologicum
Numberingvol. 35, no. S. 1, pp. 249-252
p-ISSN0350-6134
URN:NBNurn:nbn:hr:105:158081
Publication2011-01
Document URLhttps://hrcak.srce.hr/64087
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 12:05:15