prikaz prve stranice dokumenta Facial neuromuscular junctions and brainstem nuclei are the target of tetanus neurotoxin in cephalic tetanus
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Scientific paper - Original scientific paper
Facial neuromuscular junctions and brainstem nuclei are the target of tetanus neurotoxin in cephalic tetanus
JCI Insight, 8 (2023), 11; e166978. https://doi.org/10.1172/jci.insight.166978
Fabris, Federico; Varani, Stefano; Tonellato, Marika; Matak, Ivica; Šoštarić, Petra; Meglić, Patrik; Caleo, Matteo; Megighian, Aram; Rossetto, Ornella; Montecucco, Cesare; Pirazzini, Marco

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Fabris, F., Varani, S., Tonellato, M., Matak, I., Šoštarić, P., Meglić, P. ... Pirazzini, M. (2023). Facial neuromuscular junctions and brainstem nuclei are the target of tetanus neurotoxin in cephalic tetanus. JCI Insight, 8. (11). doi: 10.1172/jci.insight.166978

Fabris, Federico, et al. "Facial neuromuscular junctions and brainstem nuclei are the target of tetanus neurotoxin in cephalic tetanus." JCI Insight, vol. 8, no. 11, 2023. https://doi.org/10.1172/jci.insight.166978

Fabris, Federico, Stefano Varani, Marika Tonellato, Ivica Matak, Petra Šoštarić, Patrik Meglić, Matteo Caleo, et al. "Facial neuromuscular junctions and brainstem nuclei are the target of tetanus neurotoxin in cephalic tetanus." JCI Insight 8, no. 11 (2023). https://doi.org/10.1172/jci.insight.166978

Fabris, F., et al. (2023) 'Facial neuromuscular junctions and brainstem nuclei are the target of tetanus neurotoxin in cephalic tetanus', JCI Insight, 8(11). doi: 10.1172/jci.insight.166978

Fabris F, Varani S, Tonellato M, Matak I, Šoštarić P, Meglić P, and sur.. Facial neuromuscular junctions and brainstem nuclei are the target of tetanus neurotoxin in cephalic tetanus. JCI Insight [Internet]. 2023 May 09 [cited 2024 November 17];8(11). doi: 10.1172/jci.insight.166978

F. Fabris, et al., "Facial neuromuscular junctions and brainstem nuclei are the target of tetanus neurotoxin in cephalic tetanus", JCI Insight, vol. 8, no. 11, May 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:695304. [Accessed: 17 November 2024]

Metadata
Title (english)Facial neuromuscular junctions and brainstem nuclei are the target of tetanus neurotoxin in cephalic tetanus
AuthorFederico Fabris
AuthorStefano Varani
AuthorMarika Tonellato
AuthorIvica Matak
AuthorPetra Šoštarić
AuthorPatrik Meglić
AuthorMatteo Caleo
AuthorAram Megighian
AuthorOrnella Rossetto
AuthorCesare Montecucco
AuthorMarco Pirazzini
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Pharmacology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Pharmacology
Abstract (english)
Cephalic tetanus (CT) is a severe form of tetanus that follows head wounds and the intoxication of cranial nerves by tetanus neurotoxin (TeNT). Hallmarks of CT are cerebral palsy, which anticipates the spastic paralysis of tetanus, and rapid evolution of cardiorespiratory deficit even without generalized tetanus. How TeNT causes this unexpected flaccid paralysis, and how the canonical spasticity then rapidly evolves into cardiorespiratory defects, remain unresolved aspects of CT pathophysiology. Using electrophysiology and immunohistochemistry, we demonstrate that TeNT cleaves its substrate vesicle-associated membrane protein within facial neuromuscular junctions and causes a botulism-like paralysis overshadowing tetanus spasticity. Meanwhile, TeNT spreads among brainstem neuronal nuclei and, as shown by an assay measuring the ventilation ability of CT mice, harms essential functions like respiration. A partial axotomy of the facial nerve revealed a potentially new ability of TeNT to undergo intra-brainstem diffusion, which allows the toxin to spread to brainstem nuclei devoid of direct peripheral efferents. This mechanism is likely to be involved in the transition from local to generalized tetanus. Overall, the present findings suggest that patients with idiopathic facial nerve palsy should be immediately considered for CT and treated with antisera to block the potential progression to a life-threatening form of tetanus.
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleJCI Insight
Numberingvol. 8, no. 11, e166978
e-ISSN2379-3708
DOIhttps://doi.org/10.1172/jci.insight.166978
URN:NBNurn:nbn:hr:105:695304
Publication2023-05-09
ProjectNumber: UIP-2019-04-8277
Title (croatian): Motorički učinci klostridijskih neurotoksina u središnjem živčanom sustavu
Title (english): Motor effects of clostridial neurotoxins in central nervous system
Acronym: MEFCLO
Leader: Ivica Matak
Jurisdiction: Croatia
Funding stream: UIP
Document URLhttps://insight.jci.org/articles/view/166978
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2024-04-04 11:21:33