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Scientific paper - Review paper
Tissue optical clearing methods for microscopy: A review of their application in neuroscience
Periodicum biologorum, 125 (2023), 1-2; 115-121. https://doi.org/10.18054/pb.v125i1-2.24860
Hamer, Dominik; Petrinec, Daniela; Berecki, Monika; Glasnović, Anton; Gajović, Srećko

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

Cite this document

Hamer, D., Petrinec, D., Berecki, M., Glasnović, A. & Gajović, S. (2023). Tissue optical clearing methods for microscopy: A review of their application in neuroscience. Periodicum biologorum, 125. (1-2), 115-121. doi: 10.18054/pb.v125i1-2.24860

Hamer, Dominik, et al. "Tissue optical clearing methods for microscopy: A review of their application in neuroscience." Periodicum biologorum, vol. 125, no. 1-2, 2023, pp. 115-121. https://doi.org/10.18054/pb.v125i1-2.24860

Hamer, Dominik, Daniela Petrinec, Monika Berecki, Anton Glasnović and Srećko Gajović. "Tissue optical clearing methods for microscopy: A review of their application in neuroscience." Periodicum biologorum 125, no. 1-2 (2023): 115-121. https://doi.org/10.18054/pb.v125i1-2.24860

Hamer, D., et al. (2023) 'Tissue optical clearing methods for microscopy: A review of their application in neuroscience', Periodicum biologorum, 125(1-2), pp. 115-121. doi: 10.18054/pb.v125i1-2.24860

Hamer D, Petrinec D, Berecki M, Glasnović A, Gajović S. Tissue optical clearing methods for microscopy: A review of their application in neuroscience. Periodicum biologorum [Internet]. 2023 [cited 2024 May 15];125(1-2):115-121. doi: 10.18054/pb.v125i1-2.24860

D. Hamer, D. Petrinec, M. Berecki, A. Glasnović and S. Gajović, "Tissue optical clearing methods for microscopy: A review of their application in neuroscience", Periodicum biologorum, vol. 125, no. 1-2, pp. 115-121, 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:220373. [Accessed: 15 May 2024]

Metadata
Title (english)Tissue optical clearing methods for microscopy: A review of their application in neuroscience
AuthorDominik Hamer https://orcid.org/0000-0001-8998-4226
AuthorDaniela Petrinec https://orcid.org/0000-0003-2357-0850
AuthorMonika Berecki https://orcid.org/0000-0001-5670-163X
AuthorAnton Glasnović
AuthorSrećko Gajović
Author's institutionUniversity of Zagreb
School of Medicine
(Croatian Institiute for Brain Research)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Neuroscience
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Cytology, Histology and Embryology
Abstract (english)
Recent advances in microscopy have enabled cellular-resolution imaging of thick tissue samples or even whole organs. The natural opacity of organs and tissues acts as a barrier to light penetration and must be removed to visualise structures of interest on a three-dimensional scale. Tissue optical clearing methods achieve sample transparency while also preserving fluorescently labelled epitopes. This innovative approach to sample preparation effectively enhances traditional histological sections and, with the aid of light sheet microscopy, enables optical sectioning and three-dimensional reconstruction of entire organs, even whole brains. Light sheet microscopy of optically cleared brain samples is a valuable method in neuroscience that is used in neuro-oncology, traumatic brain injury, ischemic brain injury, and neurodegenerative disease research.In this review, we describe tissue optical clearing methods used to achieve optical transparency in brain samples. This quickly developing field has a significant potential for producing cutting-edge uses in neuroscience research.
Languageenglish
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titlePeriodicum biologorum
Numberingvol. 125, no. 1-2, pp. 115-121
p-ISSN0031-5362
e-ISSN1849-0964
DOIhttps://doi.org/10.18054/pb.v125i1-2.24860
URN:NBNurn:nbn:hr:105:220373
Publication2023
ProjectNumber: KK.01.1.1.07.0071
Title (croatian): Sinergija molekularnih biljega i multimodalnog in vivo snimanja u pretkliničkoj procjeni posljedica ishemijskog moždanog udara
Title (english): Synergy of molecular markers and multimodal in vivo imaging in preclinical assessment of ischemic stroke consequences
Leader: Srećko Gajović
Jurisdiction: eu
Document URLhttps://hrcak.srce.hr/309784
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-04-05 06:45:13