prikaz prve stranice dokumenta A rapid biochemical and radiological response to the concomitant therapy with temozolomide and radiotherapy in an aggressive ACTH pituitary adenoma
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Scientific paper - Case study
A rapid biochemical and radiological response to the concomitant therapy with temozolomide and radiotherapy in an aggressive ACTH pituitary adenoma
Case Reports in Endocrinology, 2017 (2017); 2419590. https://doi.org/10.1155/2017/2419590
Mišir Krpan, Ana; Dušek, Tina; Rakušić, Zoran; Solak, Mirsala; Kraljevic, Ivana; Bišof, Vesna; Ozretić, David; Kaštelan, Darko

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Mišir Krpan, A., Dušek, T., Rakušić, Z., Solak, M., Kraljevic, I., Bišof, V. ... Kaštelan, D. (2017). A rapid biochemical and radiological response to the concomitant therapy with temozolomide and radiotherapy in an aggressive ACTH pituitary adenoma. Case Reports in Endocrinology, 2017., 2419590. doi: 10.1155/2017/2419590

Mišir Krpan, Ana, et al. "A rapid biochemical and radiological response to the concomitant therapy with temozolomide and radiotherapy in an aggressive ACTH pituitary adenoma." Case Reports in Endocrinology, vol. 2017, 2017, p. 2419590. https://doi.org/10.1155/2017/2419590

Mišir Krpan, Ana, Tina Dušek, Zoran Rakušić, Mirsala Solak, Ivana Kraljevic, Vesna Bišof, David Ozretić and Darko Kaštelan. "A rapid biochemical and radiological response to the concomitant therapy with temozolomide and radiotherapy in an aggressive ACTH pituitary adenoma." Case Reports in Endocrinology 2017 (2017): 2419590. https://doi.org/10.1155/2017/2419590

Mišir Krpan, A., et al. (2017) 'A rapid biochemical and radiological response to the concomitant therapy with temozolomide and radiotherapy in an aggressive ACTH pituitary adenoma', Case Reports in Endocrinology, 2017, p. 2419590. doi: 10.1155/2017/2419590

Mišir Krpan A, Dušek T, Rakušić Z, Solak M, Kraljevic I, Bišof V, and sur.. A rapid biochemical and radiological response to the concomitant therapy with temozolomide and radiotherapy in an aggressive ACTH pituitary adenoma. Case Reports in Endocrinology [Internet]. 2017 [cited 2024 November 26];2017:2419590. doi: 10.1155/2017/2419590

A. Mišir Krpan, et al., "A rapid biochemical and radiological response to the concomitant therapy with temozolomide and radiotherapy in an aggressive ACTH pituitary adenoma", Case Reports in Endocrinology, vol. 2017, p. 2419590, 2017. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:681041. [Accessed: 26 November 2024]

Metadata
Title (english)A rapid biochemical and radiological response to the concomitant therapy with temozolomide and radiotherapy in an aggressive ACTH pituitary adenoma
AuthorAna Mišir Krpan
AuthorTina Dušek
AuthorZoran Rakušić
AuthorMirsala Solak
AuthorIvana Kraljevic
AuthorVesna Bišof
AuthorDavid Ozretić
AuthorDarko Kaštelan
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Background and Importance: In the last eight years temozolomide (TMZ) has been used as the last-line treatment modality for aggressive pituitary tumors to be applied after the failure of surgery, medical therapy, and radiotherapy. The objective was to achieve a rapid control of tumor growth and hormone normalization with concurrent chemoradiotherapy in a patient with very aggressive ACTH pituitary adenoma. ----- Clinical Presentation: We describe a patient with an aggressive ACTH-producing adenoma treated with concurrent temozolomide and radiotherapy. The patient suffered from an aggressive ACTH adenoma resistant to surgical and medical treatment. After two months of concurrent temozolomide and radiotherapy, cortisol normalization and significant tumor shrinkage were observed. After 22 months of follow-up, there is still no evidence of tumor recurrence. ----- Conclusion: Concurrent treatment with temozolomide and irradiation appears to be highly effective in the achievement of the tumor volume control as well as in the control of ACTH secretion in aggressive ACTH adenoma.
Languageenglish
Publication typeScientific paper - Case study
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCase Reports in Endocrinology
Numberingvol. 2017, p. 2419590
p-ISSN2090-6501
DOIhttps://doi.org/10.1155/2017/2419590
URN:NBNurn:nbn:hr:105:681041
Publication2017
Document URLhttps://doi.org/10.1155/2017/2419590
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-04-09 05:47:23