prikaz prve stranice dokumenta Effect of preoperative topical diclofenac on intraocular interleukin-12 concentration and macular edema after cataract surgery in patients with diabetic retinopathy: a randomized controlled trial
  Download
PDF 218.91 KB
Scientific paper - Original scientific paper
Effect of preoperative topical diclofenac on intraocular interleukin-12 concentration and macular edema after cataract surgery in patients with diabetic retinopathy: a randomized controlled trial
Croatian Medical Journal, 58 (2017), 1; 49-55. https://doi.org/10.3325/cmj.2017.58.49
Medić, Aleksej; Jukić, Tomislav; Matas, Anita; Vukojević, Katarina; Sapunar, Ada; Znaor, Ljubo

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

Cite this document

Medić, A., Jukić, T., Matas, A., Vukojević, K., Sapunar, A. & Znaor, Lj. (2017). Effect of preoperative topical diclofenac on intraocular interleukin-12 concentration and macular edema after cataract surgery in patients with diabetic retinopathy: a randomized controlled trial. Croatian Medical Journal, 58. (1), 49-55. doi: 10.3325/cmj.2017.58.49

Medić, Aleksej, et al. "Effect of preoperative topical diclofenac on intraocular interleukin-12 concentration and macular edema after cataract surgery in patients with diabetic retinopathy: a randomized controlled trial." Croatian Medical Journal, vol. 58, no. 1, 2017, pp. 49-55. https://doi.org/10.3325/cmj.2017.58.49

Medić, Aleksej, Tomislav Jukić, Anita Matas, Katarina Vukojević, Ada Sapunar and Ljubo Znaor. "Effect of preoperative topical diclofenac on intraocular interleukin-12 concentration and macular edema after cataract surgery in patients with diabetic retinopathy: a randomized controlled trial." Croatian Medical Journal 58, no. 1 (2017): 49-55. https://doi.org/10.3325/cmj.2017.58.49

Medić, A., et al. (2017) 'Effect of preoperative topical diclofenac on intraocular interleukin-12 concentration and macular edema after cataract surgery in patients with diabetic retinopathy: a randomized controlled trial', Croatian Medical Journal, 58(1), pp. 49-55. doi: 10.3325/cmj.2017.58.49

Medić A, Jukić T, Matas A, Vukojević K, Sapunar A, Znaor Lj. Effect of preoperative topical diclofenac on intraocular interleukin-12 concentration and macular edema after cataract surgery in patients with diabetic retinopathy: a randomized controlled trial. Croatian Medical Journal [Internet]. 2017 February 28 [cited 2024 May 04];58(1):49-55. doi: 10.3325/cmj.2017.58.49

A. Medić, T. Jukić, A. Matas, K. Vukojević, A. Sapunar and Lj. Znaor, "Effect of preoperative topical diclofenac on intraocular interleukin-12 concentration and macular edema after cataract surgery in patients with diabetic retinopathy: a randomized controlled trial", Croatian Medical Journal, vol. 58, no. 1, pp. 49-55, February 2017. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:883172. [Accessed: 04 May 2024]

Metadata
Title (english)Effect of preoperative topical diclofenac on intraocular interleukin-12 concentration and macular edema after cataract surgery in patients with diabetic retinopathy: a randomized controlled trial
AuthorAleksej Medić
AuthorTomislav Jukić
AuthorAnita Matas
AuthorKatarina Vukojević
AuthorAda Sapunar
AuthorLjubo Znaor
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
AIM: To determine if preoperative treatment with a topical non-steroidal anti-inflammatory drug (NSAID) lowers the concentration of intraocular interleukin (IL)-12 and the incidence of postoperative macular edema in patients with non-proliferative diabetic retinopathy undergoing cataract surgery. ----- METHODS: A total of 55 patients were randomized to diclofenac (n=27) or placebo (n=28). Patients receiving diclofenac started preoperative treatment with 0.1% topical diclofenac four times a day 7 days before cataract surgery and the therapy was discontinued 30 days after surgery. Patients in the control group were administered placebo 7 days preoperatively and a standard postoperative therapy with 0.1% topical dexamethasone four times a day for 30 days after surgery. All patients received postoperative antibiotic prophylaxis with tobramycin eye drops four times daily for 30 days. Seven days before the cataract surgery, on the day of surgery, and 1, 7, 30, and 90 days after surgery, central foveal thickness (CFT) was measured with optical coherence tomography (OCT) and the aqueous humor was sampled at the beginning of cataract surgery for the analysis of IL-12 concentration. Due to loss to follow-up and insufficient aqueous humor samples, the data of 3 patients treated with diclofenac and 8 patients receiving placebo were not analyzed. ----- RESULTS: The aqueous humor IL-12 concentration was significantly lower in the diclofenac group than in the placebo group (t=-2.85, p=0.007). The diclofenac group had a significantly smaller increase in CFT after phacoemulsification (F=13.57, p<0.001). ----- CONCLUSION: Patients preoperatively treated with diclofenac had significantly lower intraocular levels of IL-12 and a lower increase in CFT, which indicates that a combination of preoperative and postoperative treatment with a topical NSAID may lower the incidence of postoperative macular edema in patients with diabetic retinopathy.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCroatian Medical Journal
Numberingvol. 58, no. 1, pp. 49-55
p-ISSN0353-9504
DOIhttps://doi.org/10.3325/cmj.2017.58.49
URN:NBNurn:nbn:hr:105:883172
Publication2017-02-28
Document URLhttps://doi.org/10.3325/cmj.2017.58.49
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-04-09 05:48:16