prikaz prve stranice dokumenta Hemorrhagic Fever with Renal Syndrome Patients Exhibit Increased Levels of Lipocalin-2, Endothelin-1 and NT-proBNP
  Download
PDF 1.58 MB
Scientific paper - Original scientific paper
Hemorrhagic Fever with Renal Syndrome Patients Exhibit Increased Levels of Lipocalin-2, Endothelin-1 and NT-proBNP
Life, 13 (2023), 11; 2189. https://doi.org/10.3390/life13112189
Cvetko Krajinović, Lidija; Bodulić, Kristian; Laškaj, Renata; Žibrat, Branka; Svoboda Karić, Petra; Kurolt, Ivan-Christian; Kordun, Mihaela; Topić, Antea; Čivljak, Rok; Skuhala, Tomislava; Markotić, Alemka

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

Cite this document

Cvetko Krajinović, L., Bodulić, K., Laškaj, R., Žibrat, B., Svoboda Karić, P., Kurolt, I. C. ... Markotić, A. (2023). Hemorrhagic Fever with Renal Syndrome Patients Exhibit Increased Levels of Lipocalin-2, Endothelin-1 and NT-proBNP. Life, 13. (11). doi: 10.3390/life13112189

Cvetko Krajinović, Lidija, et al. "Hemorrhagic Fever with Renal Syndrome Patients Exhibit Increased Levels of Lipocalin-2, Endothelin-1 and NT-proBNP." Life, vol. 13, no. 11, 2023. https://doi.org/10.3390/life13112189

Cvetko Krajinović, Lidija, Kristian Bodulić, Renata Laškaj, Branka Žibrat, Petra Svoboda Karić, Ivan Christian Kurolt, Mihaela Kordun, et al. "Hemorrhagic Fever with Renal Syndrome Patients Exhibit Increased Levels of Lipocalin-2, Endothelin-1 and NT-proBNP." Life 13, no. 11 (2023). https://doi.org/10.3390/life13112189

Cvetko Krajinović, L., et al. (2023) 'Hemorrhagic Fever with Renal Syndrome Patients Exhibit Increased Levels of Lipocalin-2, Endothelin-1 and NT-proBNP', Life, 13(11). doi: 10.3390/life13112189

Cvetko Krajinović L, Bodulić K, Laškaj R, Žibrat B, Svoboda Karić P, Kurolt IC, and sur.. Hemorrhagic Fever with Renal Syndrome Patients Exhibit Increased Levels of Lipocalin-2, Endothelin-1 and NT-proBNP. Life [Internet]. 2023 November 10 [cited 2024 May 02];13(11). doi: 10.3390/life13112189

L. Cvetko Krajinović, et al., "Hemorrhagic Fever with Renal Syndrome Patients Exhibit Increased Levels of Lipocalin-2, Endothelin-1 and NT-proBNP", Life, vol. 13, no. 11, November 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:937155. [Accessed: 02 May 2024]

Metadata
Title (english)Hemorrhagic Fever with Renal Syndrome Patients Exhibit Increased Levels of Lipocalin-2, Endothelin-1 and NT-proBNP
AuthorLidija Cvetko Krajinović
AuthorKristian Bodulić
AuthorRenata Laškaj
AuthorBranka Žibrat
AuthorPetra Svoboda Karić
AuthorIvan-Christian Kurolt
AuthorMihaela Kordun
AuthorAntea Topić
AuthorRok Čivljak
AuthorTomislava Skuhala
AuthorAlemka Markotić
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Pharmacology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Pharmacology
Abstract (english)
Hemorrhagic fever with renal syndrome (HFRS) is an acute zoonotic disease caused by viruses of the Orthohantavirus genus. This syndrome is characterized by renal and cardiopulmonary implications detectable with different biomarkers. Here, we explored the role of serum and urine levels of lipocalin-2, endothelin-1 and N-terminal pro-brain natriuretic peptide (NT-proBNP) in HFRS pathology. A total of twenty-eight patients hospitalized due to a Puumala orthohantavirus infection were included, with serum and urine samples collected on patient admission (acute phase) and discharge (convalescent phase). In comparison to healthy individuals, patients exhibited significantly higher acute-phase serum and urine levels of lipocalin-2, serum levels of endothelin-1 and serum and urine levels of NT-proBNP. Patients in the convalescent phase showed a significant decrease in urine lipocalin-2, serum endothelin-1 and serum and urine NT-proBNP levels. We recorded a strong correlation between serum levels of lipocalin-2 and endothelin-1 and urine levels of lipocalin-2 with several kidney injury markers, such as serum creatinine, urea, urine white blood cell count and proteinuria. We also demonstrated an independent correlation of serum and urine lipocalin-2 levels with acute kidney injury in HFRS. All in all, our results show an involvement of NT-proBNP, lipocalin-2 and endothelin-1 in the renal and cardiac pathology of HFRS.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleLife
Numberingvol. 13, no. 11, 2189
e-ISSN2075-1729
DOIhttps://doi.org/10.3390/life13112189
URN:NBNurn:nbn:hr:105:937155
Publication2023-11-10
ProjectNumber: IP-2013-11-4393
Title (croatian): Nespecifična imunost na hantaviruse
Title (english): Innate immunity to hantaviruses
Acronym: HANTA-INNATE
Leader: Alemka Markotić
Jurisdiction: Croatia
Funding stream: IP
ProjectNumber: KK.011.1.01.0006
Title (english): Jačanje kapaciteta CerVirVac-a za istraživanja u virusnoj imunologiji i vakcinologiji
Leader: Stipan Jonjić
Jurisdiction: eu
Document URLhttps://www.mdpi.com/2075-1729/13/11/2189
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2024-04-10 13:59:43