The aim of this study was to determine the number of surgically treated patients with mucoepidermoid carcinoma of the salivary glands during a 25-year period, to analyze its distribution according to the patients’ gender, age and the localization of the tumor, and to evaluate the success of treatment. A retrospective analysis of medical records showed that from 1990 to 2014 at the Department of Maxillofacial Surgery, University Hospital Dubrava 65 patients with mucoepidermoid carcinoma of the salivary glands were treated surgically, men (52,3%) slightly more often than woman (47,7%). The patients’ average age was 46 years, with 10.8% of patients of childhood age. The most frequent localization of mucoepidermoid carcinoma was the parotid gland, with the palate being the most frequent localization of carcinoma of the minor salivary glands. Patients were most frequently treated by surgical excision or parotidectomy, and additional dissection of the cervical lymph nodes was performed on cases with advanced disease. The overall survival rate was 87,7%, which corresponds with statistical information obtained from literature concerning the survival rate for low- and intermediate-grade mucoepidermoid carcinoma. These findings confirm that surgical treatment is the optimal choice in treating patients with mucoepidermoid carcinoma of the salivary glands.