Organ transplantation is a surgical procedure in which a diseased or damaged organ is replaced with a healthy organ from a donor. This type of procedure is used to treat patients with severe and advanced organ disease that has not responded to other forms of therapy. Causes of severe heart failure as an indication for transplantation are primarily dilated and ischemic cardiomyopathy. Other causes of refractory heart failure are hypertensive heart disease, myocarditis, toxic cardiomyopathy, congenital heart disease and heart valve disease resulting in severe damage and dysfunction of the myocardium. Patient and family education after heart transplantation plays a critical role in postoperative recovery and long-term health management. The education is about taking medication, recognizing signs of rejection, the importance of regular check-ups and a healthy lifestyle. Continuous monitoring of the patient's health after a heart transplant is important for early detection of complications and organ rejection. Regular examinations, laboratory tests and diagnostic imaging methods help the medical team to make timely interventions. Long-term care for patients after heart transplantation requires a multidisciplinary approach, cooperation between the medical team and the patient, and adaptation to individual needs. Continuous support and education contribute to long-term health and quality of life of these patients.