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master's thesis
Suvremeni pristup liječenju multiplog mijeloma
Zagreb: University of Zagreb, School of Medicine, 2023. urn:nbn:hr:105:234305
Latković, Ivana
University of Zagreb
School of Medicine

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Latković, I. (2023). Suvremeni pristup liječenju multiplog mijeloma (Master's thesis). Zagreb: University of Zagreb, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:234305

Latković, Ivana. "Suvremeni pristup liječenju multiplog mijeloma." Master's thesis, University of Zagreb, School of Medicine, 2023. https://urn.nsk.hr/urn:nbn:hr:105:234305

Latković, Ivana. "Suvremeni pristup liječenju multiplog mijeloma." Master's thesis, University of Zagreb, School of Medicine, 2023. https://urn.nsk.hr/urn:nbn:hr:105:234305

Latković, I. (2023). 'Suvremeni pristup liječenju multiplog mijeloma', Master's thesis, University of Zagreb, School of Medicine, accessed 02 May 2024, https://urn.nsk.hr/urn:nbn:hr:105:234305

Latković I. Suvremeni pristup liječenju multiplog mijeloma [Master's thesis]. Zagreb: University of Zagreb, School of Medicine; 2023 [cited 2024 May 02] Available at: https://urn.nsk.hr/urn:nbn:hr:105:234305

I. Latković, "Suvremeni pristup liječenju multiplog mijeloma", Master's thesis, University of Zagreb, School of Medicine, Zagreb, 2023. Available at: https://urn.nsk.hr/urn:nbn:hr:105:234305

Metadata
TitleSuvremeni pristup liječenju multiplog mijeloma
Title (english)Modern approach in treatment of multiple myeloma
AuthorIvana Latković
MentorJosip Batinić (mentor)
Committee memberAna Boban (predsjednik povjerenstva)
Committee memberIvana Vuković Brinar (član povjerenstva)
Committee memberJosip Batinić (član povjerenstva)
GranterUniversity of Zagreb
School of Medicine
Zagreb
Defense date and country2023-09-26, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract
Multipli mijelom je zloćudni tumor koštane srži karakteriziran umnažanjem abnormalnih klonalnih plazma stanica, s mogućnošću nekontroliranog rasta uzrokujući destruktivne lezije kostiju, ozljedu bubrega, anemiju i hiperkalcijemiju. Karakterističan je za osobe starije životne dobi (medijan dobi kod dijagnoze je 69godina), češća je pojavnost kod muškaraca nego žena, te bilježi znatno veću učestalost kod crne rase. Nepoznate je etiologije. Dijagnostika bolesti izuzetno je složena, prvotni pokazatelji su anemija ili slabokrvnost u krvnoj slici, a elektroforeza proteina u serumu govori u prilog tzv. M proteina i urinu Bence Jones protein, potom punkcija koštane srži i neizostavna radiološka dijagnostika. Dugo vremena temelj liječenja MM je bila citostatska terapija u kombinaciji s drugim lijekovima poput kortikosteroida. Dostupnost nove generacije lijekova kao što su imunomodulatorna sredstva, inhibitori proteasoma i monoklonska antitijela, široka primjena transplantacije matičkih stanica, upotreba napredne dijagnostike koja omogućuje stratifikaciju rizika i praćenje odgovora na terapiju, te opće poboljšanje zdravstvene skrbi, multidisciplinaran, te holistički pristup skrbi u velike je poboljšalo ishod liječenja.
Abstract (english)
Multiple myeloma is a hematologic malignancy characterized by the presence of abnormal clonal plasma cells in the bone marrow, with the potential for uncontrolled growth causing destructive bone lesions, kidney injury, anemia, and hypercalcemia. It occurs usually in older people, it is more common in men than in women, and it has significantly higher incidence in black race than in caucasians. Etiology is unknown. Diagnostics of the disease is extremely complex, the initial indicators are the blood count that can show anemia, serum protein electrophoresis the so-called M protein and urine Bence Jones protein, then bone marrow puncture and essential radiological diagnostics. Cytostatic therapy in combination with other drugs such as corticosteroids was the mainstream terapy for MM. The availability of a new generation of drugs such as immunomodulating agents, proteasome inhibitors and monoclonal antibodies, the widespread use of stem cell transplantation, the use of advanced diagnostics that enables risk stratification and monitoring of response to therapy, and the general improvement of health care, a multidisciplinary and holistic approach to care led to a major improvement of treatment outcomes.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:105:234305
Study programmeTitle: Studies in Nursing
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra sestrinstva (magistar/magistra sestrinstva)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-04-18 09:31:05