Lymphomas in people with HIV represent one of the most common hematological malignancies and are one of the most common neoplastic causes of mortality in this patient population. Despite the widespread use of HAART and the extension of the life expectancy of patients with HIV infection, HIV-related lymphomas are the leading cause of morbidity and mortality from malignant diseases in patients with HIV/AIDS. In patients suffering from HIV-related lymphoma, the two most common groups that appear are non-Hodgkin's lymphoma and Hodgkin's lymphoma. Regular control of HIV-positive persons in order to detect the development of lymphoma in time is extremely important in order to ensure the early start of therapy and the course of treatment, to ensure the highest possible quality of life during treatment and to prolong the patient's lifespan. Through a comprehensive review of the relevant literature, we can see how the contribution of hematology nurses is unique due to the scale and diversity of roles and responsibilities in in the care of malignant diseases of the hematopoietic system. Providing integrated patient-centered care, optimal communication and providing emotional support, continuous education and infection prevention are essential components of hematology nursing care. By analyzing the needs of each patient, the adaptation of healthcare and intervention to each patient individually will lead to the maximum quality of the patient's life and the patient's satisfaction with the care provided. Also, one of the very important components in the care of patients with HIV-related lymphoma is the provision of appropriate accommodation and patient care after discharge from the hospital, i.e. at home.