Depression is 0one of the most common diseases in the modern world, and for now there are no indications that the trend of increasing depression could be stopped. It is estimated that 280 million people suffer from depression globally. A person suffering from depression suffers deeply, all their functions are changed, nothing makes them happy and they are often suicidal. This fact obliges us to be maximally trained in the field of treatment of these patients, both in diagnosis and treatment. Depression is the most common reason people see a psychiatrist, although the common man's perception is that all mental problems are depression. People show a tendency to view people with mental illnesses more negatively than positively. There are several types of depressive disorders. Clinical depression or major depressive disorder is often just called „depression“ and is the most severe type of depression. Approximately 80% to 90% of people with depression who seek treatment eventually respond well to treatment. Without treatment, depression can get worse and last longer. In severe cases, it can lead to self-harm or death. The involvement of nursing in the treatment of depression may seem important because nursing plays a central role in health care delivery where they are health practitioners who are trained to be versatile from clinical to psychological care. In order to find the most effective pharmaceutical drug treatment, drug doses often need to be adjusted, different combinations of antidepressants must be tried, or antidepressants must be changed.