prikaz prve stranice dokumenta Elderly rats fed with a high-fat high-sucrose diet developed sex-dependent metabolic syndrome regardless of long-term metformin and liraglutide treatment
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Scientific paper - Original scientific paper
Elderly rats fed with a high-fat high-sucrose diet developed sex-dependent metabolic syndrome regardless of long-term metformin and liraglutide treatment
Frontiers in Endocrinology, 14 (2023); 1181064. https://doi.org/10.3389/fendo.2023.1181064
Ivić, Vedrana; Zjalić, Milorad; Blažetić, Senka; Fenrich, Matija; Labak, Irena; Scitovski, Rudolf; Szűcs, Kálmán Ferenc; Ducza, Eszter; Tábi, Tamás; Bagamery, Fruzsina; Szökő, Éva; Vuković, Rosemary; Rončević, Alen; Mandić, Dario; Debeljak, Željko; Berecki, Monika; Balog, Marta; Seres-Bokor, Adrienn; Sztojkov-Ivanov, Anita; Hajagos-Tóth, Judit; Gajović, Srećko; Imširović, Alen; Bakula, Marina; Mahiiovych, Solomiia; Gaspar, Robert; Vari, Sandor G.; Heffer, Marija More authors...

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Ivić, V., Zjalić, M., Blažetić, S., Fenrich, M., Labak, I., Scitovski, R. ... Heffer, M. (2023). Elderly rats fed with a high-fat high-sucrose diet developed sex-dependent metabolic syndrome regardless of long-term metformin and liraglutide treatment. Frontiers in Endocrinology, 14.. doi: 10.3389/fendo.2023.1181064

Ivić, Vedrana, et al. "Elderly rats fed with a high-fat high-sucrose diet developed sex-dependent metabolic syndrome regardless of long-term metformin and liraglutide treatment." Frontiers in Endocrinology, vol. 14, 2023. https://doi.org/10.3389/fendo.2023.1181064

Ivić, Vedrana, Milorad Zjalić, Senka Blažetić, Matija Fenrich, Irena Labak, Rudolf Scitovski, Kálmán Ferenc Szűcs, et al. "Elderly rats fed with a high-fat high-sucrose diet developed sex-dependent metabolic syndrome regardless of long-term metformin and liraglutide treatment." Frontiers in Endocrinology 14 (2023). https://doi.org/10.3389/fendo.2023.1181064

Ivić, V., et al. (2023) 'Elderly rats fed with a high-fat high-sucrose diet developed sex-dependent metabolic syndrome regardless of long-term metformin and liraglutide treatment', Frontiers in Endocrinology, 14. doi: 10.3389/fendo.2023.1181064

Ivić V, Zjalić M, Blažetić S, Fenrich M, Labak I, Scitovski R, and sur.. Elderly rats fed with a high-fat high-sucrose diet developed sex-dependent metabolic syndrome regardless of long-term metformin and liraglutide treatment. Frontiers in Endocrinology [Internet]. 2023 October 20 [cited 2024 June 06];14. doi: 10.3389/fendo.2023.1181064

V. Ivić, et al., "Elderly rats fed with a high-fat high-sucrose diet developed sex-dependent metabolic syndrome regardless of long-term metformin and liraglutide treatment", Frontiers in Endocrinology, vol. 14, October 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:662491. [Accessed: 06 June 2024]

Metadata
Title (english)Elderly rats fed with a high-fat high-sucrose diet developed sex-dependent metabolic syndrome regardless of long-term metformin and liraglutide treatment
AuthorVedrana Ivić
AuthorMilorad Zjalić
AuthorSenka Blažetić
AuthorMatija Fenrich
AuthorIrena Labak
AuthorRudolf Scitovski
AuthorKálmán Ferenc Szűcs
AuthorEszter Ducza
AuthorTamás Tábi
AuthorFruzsina Bagamery
AuthorÉva Szökő
AuthorRosemary Vuković
AuthorAlen Rončević
AuthorDario Mandić
AuthorŽeljko Debeljak
AuthorMonika Berecki
AuthorMarta Balog
AuthorAdrienn Seres-Bokor
AuthorAnita Sztojkov-Ivanov
AuthorJudit Hajagos-Tóth
AuthorSrećko Gajović
AuthorAlen Imširović
AuthorMarina Bakula
AuthorSolomiia Mahiiovych
AuthorRobert Gaspar
AuthorSandor G. Vari
AuthorMarija Heffer
Author's institutionUniversity of Zagreb
School of Medicine
(Croatian Institiute for Brain Research)
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Histology and Embryology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Cytology, Histology and Embryology
Abstract (english)
Aim/introduction: The study aimed to determine the effectiveness of early antidiabetic therapy in reversing metabolic changes caused by high-fat and high-sucrose diet (HFHSD) in both sexes. Methods: Elderly Sprague-Dawley rats, 45 weeks old, were randomized into four groups: a control group fed on the standard diet (STD), one group fed the HFHSD, and two groups fed the HFHSD along with long-term treatment of either metformin (HFHSD+M) or liraglutide (HFHSD+L). Antidiabetic treatment started 5 weeks after the introduction of the diet and lasted 13 weeks until the animals were 64 weeks old. Results: Unexpectedly, HFHSD-fed animals did not gain weight but underwent significant metabolic changes. Both antidiabetic treatments produced sex-specific effects, but neither prevented the onset of prediabetes nor diabetes. Conclusion: Liraglutide vested benefits to liver and skeletal muscle tissue in males but induced signs of insulin resistance in females.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleFrontiers in Endocrinology
Numberingvol. 14, 1181064
e-ISSN1664-2392
DOIhttps://doi.org/10.3389/fendo.2023.1181064
URN:NBNurn:nbn:hr:105:662491
Publication2023-10-20
Document URLhttps://www.frontiersin.org/articles/10.3389/fendo.2023.1181064/full
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2024-05-06 08:33:30