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doctoral thesis
Utjecaj farmakogenetičkih varijacija P-glikoproteina i inozin-5'-monofosfat dehidrogenaze na ishode liječenja bolesnika s transplantiranim bubregom
Zagreb: University of Zagreb, School of Medicine, 2024. urn:nbn:hr:105:481191
Penezić, Luka
University of Zagreb
School of Medicine

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Penezić, L. (2024). Utjecaj farmakogenetičkih varijacija P-glikoproteina i inozin-5'-monofosfat dehidrogenaze na ishode liječenja bolesnika s transplantiranim bubregom (Doctoral thesis). Zagreb: University of Zagreb, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:481191

Penezić, Luka. "Utjecaj farmakogenetičkih varijacija P-glikoproteina i inozin-5'-monofosfat dehidrogenaze na ishode liječenja bolesnika s transplantiranim bubregom." Doctoral thesis, University of Zagreb, School of Medicine, 2024. https://urn.nsk.hr/urn:nbn:hr:105:481191

Penezić, Luka. "Utjecaj farmakogenetičkih varijacija P-glikoproteina i inozin-5'-monofosfat dehidrogenaze na ishode liječenja bolesnika s transplantiranim bubregom." Doctoral thesis, University of Zagreb, School of Medicine, 2024. https://urn.nsk.hr/urn:nbn:hr:105:481191

Penezić, L. (2024). 'Utjecaj farmakogenetičkih varijacija P-glikoproteina i inozin-5'-monofosfat dehidrogenaze na ishode liječenja bolesnika s transplantiranim bubregom', Doctoral thesis, University of Zagreb, School of Medicine, accessed 08 July 2024, https://urn.nsk.hr/urn:nbn:hr:105:481191

Penezić L. Utjecaj farmakogenetičkih varijacija P-glikoproteina i inozin-5'-monofosfat dehidrogenaze na ishode liječenja bolesnika s transplantiranim bubregom [Doctoral thesis]. Zagreb: University of Zagreb, School of Medicine; 2024 [cited 2024 July 08] Available at: https://urn.nsk.hr/urn:nbn:hr:105:481191

L. Penezić, "Utjecaj farmakogenetičkih varijacija P-glikoproteina i inozin-5'-monofosfat dehidrogenaze na ishode liječenja bolesnika s transplantiranim bubregom", Doctoral thesis, University of Zagreb, School of Medicine, Zagreb, 2024. Available at: https://urn.nsk.hr/urn:nbn:hr:105:481191

Metadata
TitleUtjecaj farmakogenetičkih varijacija P-glikoproteina i inozin-5'-monofosfat dehidrogenaze na ishode liječenja bolesnika s transplantiranim bubregom
Title (english)The effect of pharmacogenetic variations of P-glycoprotein and inosine-5'-monophosphate dehydrogenase on treatment outcomes in patients with kidney transplant
AuthorLuka Penezić
MentorŽeljko Kaštelan (mentor)
MentorNada Božina (komentor)
Committee memberJelena Osmanović (predsjednik povjerenstva)
Committee memberNikola Knežević (član povjerenstva)
Committee memberBojan Jelaković (član povjerenstva)
GranterUniversity of Zagreb
School of Medicine
Zagreb
Defense date and country2024-05-07, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Urology
Universal decimal classification
(UDC)		616 - Pathology. Clinical medicine
Abstract
Transplantacija bubrega je metoda izbora za liječenje pacijenata sa završnim stadijem kronične bubrežne bolesti. Imunosupresivna terapija predstavlja osnovu dugoročnog preživljena transplantiranog bubrega. U novom dobu personalizirane medicine, farmakogenetička istraživanja pružaju uvid kako različite genske varijacije mogu utjecati na ishod liječenja. U okviru ovog istraživanja, analizirana je veza između određenih genetskih polimorfizama - specifično, varijacija gena za IMPDH2 (rs11706052) i P-glikoproteina, ABCB1 (rs1128503, rs2032582 i rs1045642) - i ishoda transplantacije. Ukupno 254 pacijenta, koji su podvrgnuti transplantaciji bubrega i koji su primali standardnu imunosupresivnu terapiju, praćeni su tijekom 12 mjeseci. Uz analizu eGFR, kao primarnog pokazatelja funkcije presatka, također su razmatrani i drugi klinički ishodi poput odbacivanja organa, smrti i nuspojava terapije. Rezultati su ukazali na neznatne razlike u funkciji presatka među pacijentima s različitim genskim varijacijama. Odnosno, nisu pronađeni uvjerljivi dokazi da bilo koja od ispitivanih genskih varijacija negativno utječe na ishod transplantacije tijekom prve godine. To nam sugerira da, iako genetička komponenta može igrati ulogu u mnogim aspektima zdravlja, specifični polimorfizmi koji su istraženi u ovoj studiji, ne igraju presudnu ulogu u odgovoru pacijenta na imunosupresivnu terapiju nakon transplantacije bubrega.
Abstract (english)
Kidney transplantation is the primary therapeutic intervention for patients presenting with end-stage chronic kidney disease. The efficacy of immunosuppressive therapy serves as a fundamental determinant for the long-term viability of the transplanted graft. In the evolving paradigm of personalized medicine, pharmacogenetic investigations elucidate the role of distinct genetic variations in modulating treatment outcomes. In this study, associations between specific genetic polymorphisms — notably those pertaining to IMPDH2 (rs11706052) and P-glycoprotein, ABCB1 (rs1128503, rs2032582, and rs1045642) — and transplantation outcomes were methodically analyzed. A cohort of 254 patients, who underwent kidney transplantation and were administered standard immunosuppressive regimen, were longitudinally monitored over a span of 12 months. In addition to the analysis of eGFR as a main indicator of graft function and primary outcome, other clinical endpoints including graft rejection, mortality, and therapy-related adverse events were also evaluated. Data analyses revealed negligible disparities in graft function based on genetic variations. Notably, the research found an absence of compelling evidence linking the investigated genetic polymorphisms with detrimental transplantation outcomes during the initial post-operative year. This underscores the inference that, while genetics undeniably influence various health parameters, the specific polymorphisms evaluated in this study do not markedly alter the patient's response to immunosuppressive therapy after kidney transplantation.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:105:481191
Study programmeTitle: Biomedicine and Health Sciences
Study programme type: university
Study level: postgraduate
Academic / professional title: doktor/doktorica znanosti, područje biomedicine i zdravstvo (doktor/doktorica znanosti, područje biomedicine i zdravstvo)
Type of resourceText
Extent105 str.
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-05-13 10:45:30