Systemic lupus erythematosus (SLE) is an autoimmune disease that primarily affects women of reproductive age. Pregnancy and its outcome are the main concern for most patients. The risk of exacerbation of the disease during pregnancy and the risk of miscarriage and premature birth are higher, and the increased need for safer treatment. With the advancement of the understanding of the pathogenesis of systemic lupus erythematosus and the necessity of the use of immunosuppressive therapy can be achieved by good control of the disease and the patient is now provided an opportunity to conceive and have children. Advice on pregnancy and close cooperation with other specialists such as gynecologists and rheumatologists is essential for the ideal outcome of both mother and child during pregnancy. In this review, I have also discussed the important issues such as planning pregnancy, contraception, exacerbations of the disease in pregnancy, pregnancy complications and the outcome of pregnancy. Also shown is the systematic monitoring plan such as pregnancy and review of medicines used today, topics that are closely related to the pregnancy, such as lactation and neonatal lupus.