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Scientific paper - Original scientific paper
Relationship between β-Cell Autoantibodies and Their Combination with Anthropometric and Metabolic Components and Microvascular Complications in Latent Autoimmune Diabetes in Adults
Biomedicines, 11 (2023), 9; 2561. https://doi.org/10.3390/biomedicines11092561
Bulum, Tomislav; Vučić Lovrenčić, Marijana; Knežević Ćuća, Jadranka; Tomić, Martina; Vučković-Rebrina, Sandra; Duvnjak, Lea

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Bulum, T., Vučić Lovrenčić, M., Knežević Ćuća, J., Tomić, M., Vučković Rebrina, S. & Duvnjak, L. (2023). Relationship between β-Cell Autoantibodies and Their Combination with Anthropometric and Metabolic Components and Microvascular Complications in Latent Autoimmune Diabetes in Adults. Biomedicines, 11. (9). doi: 10.3390/biomedicines11092561

Bulum, Tomislav, et al. "Relationship between β-Cell Autoantibodies and Their Combination with Anthropometric and Metabolic Components and Microvascular Complications in Latent Autoimmune Diabetes in Adults." Biomedicines, vol. 11, no. 9, 2023. https://doi.org/10.3390/biomedicines11092561

Bulum, Tomislav, Marijana Vučić Lovrenčić, Jadranka Knežević Ćuća, Martina Tomić, Sandra Vučković Rebrina and Lea Duvnjak. "Relationship between β-Cell Autoantibodies and Their Combination with Anthropometric and Metabolic Components and Microvascular Complications in Latent Autoimmune Diabetes in Adults." Biomedicines 11, no. 9 (2023). https://doi.org/10.3390/biomedicines11092561

Bulum, T., et al. (2023) 'Relationship between β-Cell Autoantibodies and Their Combination with Anthropometric and Metabolic Components and Microvascular Complications in Latent Autoimmune Diabetes in Adults', Biomedicines, 11(9). doi: 10.3390/biomedicines11092561

Bulum T, Vučić Lovrenčić M, Knežević Ćuća J, Tomić M, Vučković Rebrina S, Duvnjak L. Relationship between β-Cell Autoantibodies and Their Combination with Anthropometric and Metabolic Components and Microvascular Complications in Latent Autoimmune Diabetes in Adults. Biomedicines [Internet]. 2023 September 18 [cited 2024 November 23];11(9). doi: 10.3390/biomedicines11092561

T. Bulum, M. Vučić Lovrenčić, J. Knežević Ćuća, M. Tomić, S. Vučković Rebrina and L. Duvnjak, "Relationship between β-Cell Autoantibodies and Their Combination with Anthropometric and Metabolic Components and Microvascular Complications in Latent Autoimmune Diabetes in Adults", Biomedicines, vol. 11, no. 9, September 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:958001. [Accessed: 23 November 2024]

Metadata
Title (english)Relationship between β-Cell Autoantibodies and Their Combination with Anthropometric and Metabolic Components and Microvascular Complications in Latent Autoimmune Diabetes in Adults
AuthorTomislav Bulum
AuthorMarijana Vučić Lovrenčić
AuthorJadranka Knežević Ćuća
AuthorMartina Tomić
AuthorSandra Vučković-Rebrina
AuthorLea Duvnjak
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
Aims: Our study aimed to investigate the relationship between three autoantibodies and their combination with anthropometric and metabolic components and microvascular complications in patients with latent autoimmune diabetes in adults (LADA). Methods: Our study included 189 LADA patients divided into four subgroups according to the autoantibodies present: glutamic acid decarboxylase autoantibodies (GADA) only; zinc transporter-8 autoantibodies (ZnT8A)+GADA; insulinoma-associated-2 autoantibodies (IA-2)+GADA; and ZnT8+IA-2+GADA. Results: Compared to GADA positivity only, patients with ZnT8+GADA positivity and ZnT8+IA-2+GADA positivity had a shorter diabetes duration and lower body mass index (BMI); patients with ZnT8+GADA positivity were younger and showed an increase in glomerular filtration rate, while those with ZnT8+IA-2+GADA positivity had lower C-peptide and lower insulin resistance measured with HOMA2-IR. In a multiple regression analysis, ZnT8 positivity was associated with lower BMI (p = 0.0024), female sex (p = 0.0005), and shorter duration of disease (p = 0.0034), while IA-2 positivity was associated with lower C-peptide levels (p = 0.0034) and shorter diabetes duration (p = 0.02). No association between antibody positivity and microvascular complications of diabetes, including retinopathy, neuropathy, and microalbuminuria, as well as with variables of glucose control and β-cell function were found. Conclusion: The results of our study suggest that ZnT8 and IA-2 autoantibodies are present in a significant number of LADA patients and associated with clinical and metabolic characteristics resembling classic type 1 diabetes. Due to increased LADA prevalence, earlier identification of patients requiring frequent monitoring with the earlier intensification of insulin therapy might be of special clinical interest.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleBiomedicines
Numberingvol. 11, no. 9, 2561
e-ISSN2227-9059
DOIhttps://doi.org/10.3390/biomedicines11092561
URN:NBNurn:nbn:hr:105:958001
Publication2023-09-18
Document URLhttps://www.mdpi.com/2227-9059/11/9/2561
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2024-05-21 09:11:52