prikaz prve stranice dokumenta Plasma Brain-Derived Neurotrophic Factor Levels in First-Episode and Recurrent Major Depression and before and after Bright Light Therapy in Treatment-Resistant Depression
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Scientific paper - Original scientific paper
Plasma Brain-Derived Neurotrophic Factor Levels in First-Episode and Recurrent Major Depression and before and after Bright Light Therapy in Treatment-Resistant Depression
Biomolecules, 13 (2023), 9; 1425. https://doi.org/10.3390/biom13091425
Kosanović Rajačić, Biljana; Šagud, Marina; Begić, Dražen; Nikolac Perković, Matea; Dvojković, Anja; Ganoci, Lana; Pivac, Nela

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Kosanović Rajačić, B., Šagud, M., Begić, D., Nikolac Perković, M., Dvojković, A., Ganoci, L. & Pivac, N. (2023). Plasma Brain-Derived Neurotrophic Factor Levels in First-Episode and Recurrent Major Depression and before and after Bright Light Therapy in Treatment-Resistant Depression. Biomolecules, 13. (9). doi: 10.3390/biom13091425

Kosanović Rajačić, Biljana, et al. "Plasma Brain-Derived Neurotrophic Factor Levels in First-Episode and Recurrent Major Depression and before and after Bright Light Therapy in Treatment-Resistant Depression." Biomolecules, vol. 13, no. 9, 2023. https://doi.org/10.3390/biom13091425

Kosanović Rajačić, Biljana, Marina Šagud, Dražen Begić, Matea Nikolac Perković, Anja Dvojković, Lana Ganoci and Nela Pivac. "Plasma Brain-Derived Neurotrophic Factor Levels in First-Episode and Recurrent Major Depression and before and after Bright Light Therapy in Treatment-Resistant Depression." Biomolecules 13, no. 9 (2023). https://doi.org/10.3390/biom13091425

Kosanović Rajačić, B., et al. (2023) 'Plasma Brain-Derived Neurotrophic Factor Levels in First-Episode and Recurrent Major Depression and before and after Bright Light Therapy in Treatment-Resistant Depression', Biomolecules, 13(9). doi: 10.3390/biom13091425

Kosanović Rajačić B, Šagud M, Begić D, Nikolac Perković M, Dvojković A, Ganoci L, and sur.. Plasma Brain-Derived Neurotrophic Factor Levels in First-Episode and Recurrent Major Depression and before and after Bright Light Therapy in Treatment-Resistant Depression. Biomolecules [Internet]. 2023 September 20 [cited 2024 July 31];13(9). doi: 10.3390/biom13091425

B. Kosanović Rajačić, et al., "Plasma Brain-Derived Neurotrophic Factor Levels in First-Episode and Recurrent Major Depression and before and after Bright Light Therapy in Treatment-Resistant Depression", Biomolecules, vol. 13, no. 9, September 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:916343. [Accessed: 31 July 2024]

Metadata
Title (english)Plasma Brain-Derived Neurotrophic Factor Levels in First-Episode and Recurrent Major Depression and before and after Bright Light Therapy in Treatment-Resistant Depression
AuthorBiljana Kosanović Rajačić
AuthorMarina Šagud
AuthorDražen Begić
AuthorMatea Nikolac Perković
AuthorAnja Dvojković
AuthorLana Ganoci
AuthorNela Pivac
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Psychiatry and Psychological Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Brain-derived neurotrophic factor (BDNF) is implicated in the etiology and treatment response in major depressive disorder (MDD). However, peripheral BDNF concentrations have not been compared across different MDD stages. Bright light therapy (BLT) offers some potential in treatment-resistant depression (TRD), but its effects on BDNF levels are unknown. This study included a cross-sectional analysis of plasma BDNF concentration in females with TRD, unmedicated MDD patients, and healthy controls (HC), and measurements of longitudinal BLT effects on plasma BDNF levels in TRD patients. The present study included 55 drug-naïve, first-episode patients, 25 drug-free recurrent-episode MDD patients, 71 HC participants, and 54 TRD patients. Patients were rated by Hamilton Depression Rating Scale (HAMD)-17 and the Montgomery–Åsberg Depression Rating Scale (MADRS). Patients with TRD received BLT during 4 weeks. The total HAMD-17 and MADRS scores decreased following BLT. All patient groups had lower plasma BDNF than HC, but BDNF levels did not differ between first- and recurrent-episode BDNF patients and TRD patients before or after BLT. However, responders and remitters to BLT had higher post-treatment plasma BDNF concentrations than patients who did not achieve response or remission. The changes in plasma BDNF levels may be candidates for biomarkers of treatment response to BLT in TRD patients.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleBiomolecules
Numberingvol. 13, no. 9, 1425
e-ISSN2218-273X
DOIhttps://doi.org/10.3390/biom13091425
URN:NBNurn:nbn:hr:105:916343
Publication2023-09-20
ProjectNumber: IPS-2022-02-2497
Title (croatian): Cirkulirajuće ekstracelularne vezikule kao prediktori antidepresivnog odgovora: Praćenje mehanizma djelovanja novih terapijskih pristupa u depresiji
Title (english): Circulating Extracellular Vesicles as Predictors of Antidepressant Response: Monitoring the Mechanism of Novel Therapeutic Approaches in Depression
Acronym: EVroPAR
Leader: Matea Nikolac Perković
Jurisdiction: Croatia
Funding stream: Slovenian-Croatian Bilateral Projects
Document URLhttps://www.mdpi.com/2218-273X/13/9/1425
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2024-05-21 09:24:42