prikaz prve stranice dokumenta Celf4 controls mRNA translation underlying synaptic development in the prenatal mammalian neocortex
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Scientific paper - Original scientific paper
Celf4 controls mRNA translation underlying synaptic development in the prenatal mammalian neocortex
Nature Communications, 14 (2023), 1; 6025. https://doi.org/10.1038/s41467-023-41730-8
Salamon, Iva; Park, Yongkyu; Miškić, Terezija; Kopić, Janja; Matteson, Paul; Page, Nicholas F.; Roque, Alfonso; McAuliffe, Geoffrey W.; Favate, John; Garcia-Forn, Marta; Shah, Premal; Judaš, Miloš; Millonig, James H.; Kostović, Ivica; De Rubeis, Silvia; Hart, Ronald P.; Krsnik, Željka; Rasin, Mladen-Roko More authors...

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Salamon, I., Park, Y., Miškić, T., Kopić, J., Matteson, P., Page, N. F. ... Rasin, M. R. (2023). Celf4 controls mRNA translation underlying synaptic development in the prenatal mammalian neocortex. Nature Communications, 14. (1). doi: 10.1038/s41467-023-41730-8

Salamon, Iva, et al. "Celf4 controls mRNA translation underlying synaptic development in the prenatal mammalian neocortex." Nature Communications, vol. 14, no. 1, 2023. https://doi.org/10.1038/s41467-023-41730-8

Salamon, Iva, Yongkyu Park, Terezija Miškić, Janja Kopić, Paul Matteson, Nicholas F. Page, Alfonso Roque, et al. "Celf4 controls mRNA translation underlying synaptic development in the prenatal mammalian neocortex." Nature Communications 14, no. 1 (2023). https://doi.org/10.1038/s41467-023-41730-8

Salamon, I., et al. (2023) 'Celf4 controls mRNA translation underlying synaptic development in the prenatal mammalian neocortex', Nature Communications, 14(1). doi: 10.1038/s41467-023-41730-8

Salamon I, Park Y, Miškić T, Kopić J, Matteson P, Page NF, and sur.. Celf4 controls mRNA translation underlying synaptic development in the prenatal mammalian neocortex. Nature Communications [Internet]. 2023 September 27 [cited 2024 December 24];14(1). doi: 10.1038/s41467-023-41730-8

I. Salamon, et al., "Celf4 controls mRNA translation underlying synaptic development in the prenatal mammalian neocortex", Nature Communications, vol. 14, no. 1, September 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:613610. [Accessed: 24 December 2024]

Metadata
Title (english)Celf4 controls mRNA translation underlying synaptic development in the prenatal mammalian neocortex
AuthorIva Salamon
AuthorYongkyu Park
AuthorTerezija Miškić
AuthorJanja Kopić
AuthorPaul Matteson
AuthorNicholas F. Page
AuthorAlfonso Roque
AuthorGeoffrey W. McAuliffe
AuthorJohn Favate
AuthorMarta Garcia-Forn
AuthorPremal Shah
AuthorMiloš Judaš
AuthorJames H. Millonig
AuthorIvica Kostović
AuthorSilvia De Rubeis
AuthorRonald P. Hart
AuthorŽeljka Krsnik
AuthorMladen-Roko Rasin
Author's institutionUniversity of Zagreb
School of Medicine
(Croatian Institiute for Brain Research)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Neuroscience
Abstract (english)
Abnormalities in neocortical and synaptic development are linked to neurodevelopmental disorders. However, the molecular and cellular mechanisms governing initial synapse formation in the prenatal neocortex remain poorly understood. Using polysome profiling coupled with snRNAseq on human cortical samples at various fetal phases, we identify human mRNAs, including those encoding synaptic proteins, with finely controlled translation in distinct cell populations of developing frontal neocortices. Examination of murine and human neocortex reveals that the RNA binding protein and translational regulator, CELF4, is expressed in compartments enriched in initial synaptogenesis: the marginal zone and the subplate. We also find that Celf4/CELF4-target mRNAs are encoded by risk genes for adverse neurodevelopmental outcomes translating into synaptic proteins. Surprisingly, deleting Celf4 in the forebrain disrupts the balance of subplate synapses in a sex-specific fashion. This highlights the significance of RNA binding proteins and mRNA translation in evolutionarily advanced synaptic development, potentially contributing to sex differences.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleNature Communications
Numberingvol. 14, no. 1, 6025
e-ISSN2041-1723
DOIhttps://doi.org/10.1038/s41467-023-41730-8
URN:NBNurn:nbn:hr:105:613610
Publication2023-09-27
Document URLhttps://www.nature.com/articles/s41467-023-41730-8
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2024-05-21 10:36:46