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doctoral thesis
Povezanost simptoma anksioznosti, depresije i stresa sa simptomima poremećaja autonomnog živčanog sustava
Zagreb: University of Zagreb, School of Medicine, 2024. urn:nbn:hr:105:960236
Junaković, Anamari
University of Zagreb
School of Medicine

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Junaković, A. (2024). Povezanost simptoma anksioznosti, depresije i stresa sa simptomima poremećaja autonomnog živčanog sustava (Doctoral thesis). Zagreb: University of Zagreb, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:960236

Junaković, Anamari. "Povezanost simptoma anksioznosti, depresije i stresa sa simptomima poremećaja autonomnog živčanog sustava." Doctoral thesis, University of Zagreb, School of Medicine, 2024. https://urn.nsk.hr/urn:nbn:hr:105:960236

Junaković, Anamari. "Povezanost simptoma anksioznosti, depresije i stresa sa simptomima poremećaja autonomnog živčanog sustava." Doctoral thesis, University of Zagreb, School of Medicine, 2024. https://urn.nsk.hr/urn:nbn:hr:105:960236

Junaković, A. (2024). 'Povezanost simptoma anksioznosti, depresije i stresa sa simptomima poremećaja autonomnog živčanog sustava', Doctoral thesis, University of Zagreb, School of Medicine, accessed 23 December 2024, https://urn.nsk.hr/urn:nbn:hr:105:960236

Junaković A. Povezanost simptoma anksioznosti, depresije i stresa sa simptomima poremećaja autonomnog živčanog sustava [Doctoral thesis]. Zagreb: University of Zagreb, School of Medicine; 2024 [cited 2024 December 23] Available at: https://urn.nsk.hr/urn:nbn:hr:105:960236

A. Junaković, "Povezanost simptoma anksioznosti, depresije i stresa sa simptomima poremećaja autonomnog živčanog sustava", Doctoral thesis, University of Zagreb, School of Medicine, Zagreb, 2024. Available at: https://urn.nsk.hr/urn:nbn:hr:105:960236

Metadata
TitlePovezanost simptoma anksioznosti, depresije i stresa sa simptomima poremećaja autonomnog živčanog sustava
Title (english)The influence of the simptoms of depression, anxiety and stress on the result of COMPASS-31
AuthorAnamari Junaković
MentorMario Habek (mentor)
MentorMilena Skočić Hanžek (komentor)
Committee memberBranko Malojčić (predsjednik povjerenstva)
Committee memberGoran Šimić (član povjerenstva)
Committee memberMarina Šagud (član povjerenstva)
Committee memberMagdalena Krbot Skorić (član povjerenstva)
Committee memberArijana Lovrenčić-Huzjan (član povjerenstva)
GranterUniversity of Zagreb
School of Medicine
Zagreb
Defense date and country2024-05-21, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Neurology
Universal decimal classification
(UDC)		616 - Pathology. Clinical medicine
Abstract
Ciljevi: Istražili smo utjecaj simptoma depresije, anksioznosti i stresa na rezultate upitnika COMPASS-31 u velikoj populaciji ispitanika upućenih na tilt table test i zdravih ispitanika (HC). Metode: Uključeno je 959 uzastopnih ispitanika upućenih na tilt table test i 518 HC. Svi ispitanici su ispunili hrvatsku verziju upitnika Composite autonomic symptom score-31 (COMPASS-31). Simptomi depresije, anksioznosti i stresa procijenjeni su hrvatskom verzijom upitnika Depression, anxiety and stress scale-21 (DASS-21). Korigirali smo rezultat COMPASS-31 s neovisnim prediktorima kako bismo poboljšali specifičnost testa. Rezultati: U obje skupine (ispitanici upućeni na TTT i HC) COMPASS-31 bio je viši u ispitanika sa simptomima depresije, anksioznosti i stresa (svi p < 0,001). U multivarijabilnoj linearnoj regresijskoj analizi, HC je bio negativan, dok su ženski spol, simptomi depresije, anksioznosti i stresa bili nezavisni pozitivni prediktori COMPASS-31. COMPASS-31 u zdravih ispitanika imao je medijan od 7,913, a ovu smo vrijednost koristili kao referentnu točku za analizu osjetljivosti i specifičnosti s pitanjem kako se ova vrijednost razlikuje između HC i ispitanika upućenih na TTT. COMAPSS-31 je imao visoku osjetljivost od 87% i nisku specifičnost od 50%. Kako bismo prilagodili vrijednost COMPASS-31 s parametrima koji su bili značajni u modelu multivarijabilne linearne regresije, izračunali smo novi korigirani COMAPSS-31 (cCOMPASS-31), koji je imao usporedivu osjetljivost od 77%, ali povećanu specifičnost 73%. Zaključak: Ovo je istraživanje pokazalo da simptomi depresije, anksioznosti i stresa pogoršavaju percipiranu ozbiljnost autonomnih simptoma kod ljudi sa simptomima ortostatske intolerancije i zdrave populacije. cCOMPASS-31 je vrijedan alat koji može pomoći kliničarima u prepoznavanju prave autonomne pozadine kod osoba sa pritužbom na simptome poremećaja autonomnog živčanog sustava.
Abstract (english)
Objectives: We evaluated the influence of symptoms of depression, anxiety, and stress on the results of COMPASS-31 in a large population of people referred to tilt table testing and healthy controls (HC). Methods: 959 consecutive patients referred to tilt table testing and 518 HC were enrolled. All participants completed Composite Autonomic Symptom Score-31 (COMPASS-31). Depression, anxiety and stress symptoms were evaluated by Depression, Anxiety and Stress Scale-21 (DASS-21) questionnaire. We corrected the result of the COMPASS-31 with the independent predictors in order to improve the specificity of the test. Results: In both groups (patients and HC) COMPASS-31 was higher in participants with depression, anxiety, and stress symptoms (all p<0.001). In a multivariable linear regression analysis, HC was negative, while female sex, symptoms of depression, anxiety, and stress were independent positive predictors of COMPASS-31. COMPASS-31 in healthy controls had a median of 7.913, and we used this value as a reference point for sensitivity and specificity analysis with a question of how this value differentiates between HC and patients. COMAPSS-31 had a high sensitivity of 87% and low specificity of 50%. In order to adjust the value of COMPASS-31 with the parameters that were significant in the multivariable linear regression model, we calculated the new corrected COMAPSS-31 (cCOMPASS-31), which had comparable sensitivity of 77%, but an increased specificity of 73%. Conclusion: This study has shown that symptoms of depression, anxiety, and stress worsen the perceived severity of autonomic symptoms in people with symptoms of orthostatic intolerance and healthy population. cCOMPASS-31 is a valuable tool that can help clinicians in discerning the true autonomic background of patients’ complaints.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:105:960236
Study programmeTitle: Biomedicine and Health Sciences
Study programme type: university
Study level: postgraduate
Academic / professional title: doktor/doktorica znanosti, područje biomedicine i zdravstvo (doktor/doktorica znanosti, područje biomedicine i zdravstvo)
Type of resourceText
Extent94 str.
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-06-03 07:51:34