Eosinophilic esophagitis (EoE) is a chronic disease mediated by immune/antigenic pathophysiological mechanisms, characterized predominantly by eosinophilic inflammation of the esophageal mucosa. Exposure to certain nutritional and/or inhaled allergens stimulates cytokine activation of eosinophils. By attracting other inflammatory cells to the esophageal mucosa, the barrier is disrupted, which is evident in endoscopic and histological findings. Clinically, in children it manifests most commonly as abdominal pain, followed by dysphagia, food bolus impaction, and odynophagia. We have witnessed an increase in prevalence of EoE over the past decade, which makes the documentation of 15 years of experience at a single center significant for the ongoing monitoring of this polygenic disease, whose timely treatment prevents chronic mucosal remodeling and the development of esophageal fibrosis. The aim of this study was to examine the occurrence, clinical phenotype, and endoscopic features in a group of children with EoE treated in the Pediatrics Clinic at Sisters of Charity University Hospital from January 1, 2009, to January 1, 2024. Data were collected from the digital archive of official hospital documentation. The study included 36 participants aged 5 to17 years (average age 12.78 years). EoE clinically manifested as abdominal pain in 19 (53%) patients. Dysphagia (30%), odynophagia (8%), and food bolus impaction (25%) were recorded exclusively in boys. Among associated atopic features, allergic rhinitis was most common (30%), followed by asthma (25%) and atopic dermatitis (17%). Nutritional sensitization was identified in 72% of patients, inhalational in 44%. For diagnosis, the histological finding describing the number of eosinophils in a biopsy sample of the esophageal mucosa (inflammatory infiltration) is crucial, with the highest number of patients (33%) having 20-30 eosinophils per high power field (HPF). According to the EoE endoscopic scoring system, EREFS (Endoscopic Reference Score), the most commonly validated changes in were EREFS 2 (33%), followed by EREFS 1 and 3 (22%), and EREFS 4 in less than 3% of patients. A key part of the study was dividing patients into two groups based on the presence of atopy and comparing the severity of the disease depending on group membership. A more severe degree of changes, according to the EREFS score, was described in patients with atopy, also with a higher prevalence of dysphagic symptoms. These results emphasize the fact that in patients with atopy who report symptoms of esophageal dysfunction, it is important to suspect EoE and expect locally advanced inflammation.