Multiple sclerosis is an autoimmune disease with chronic progressive course. The immune system in the disease damages the myelin lining of the nerves, leading to impaired axone conduction, which is manifested by neurological outbursts depending on the location of the lesion. As urination is regulated from multiple centers located in different locations in the nervous system, lesions at any of these locations can lead to urinary disturbances. In 42 subjects, neurological status was performed with determination of EDSS and urinary FS, SSEP n. medianus and tibialis were recorded, and all subjects fulfill ICIQ quality of life and overactive bladder rating scale. The last available brain and spinal cord MRI recorded as part of routine work-up was analysed. The aim of the study was to determine the correlation of neurological status, neurophysiological and neuroradiological work-up with the results of the ICIQ questionnaires. The results of the study showed a statistically significant association of the ICIQ questionnaire with clinical parameters EDSS and urinary FS as well as with P40 wave values in SSEP n. tibialis. The correlation between neurological disability and SSEP n. tibialis values was once again confirmed. Multimodal evaluation of patients and specialized questionnaires can objectify problems with the urinary system that often accompany MS patients and greatly impair their quality of life, allowing them to receive early treatment.