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professional thesis
Manjak fibrinogena i primjena viskoelastičnih testova u bolesnika s traumatskom koagulopatijom
Zagreb: University of Zagreb, School of Medicine, 2024. urn:nbn:hr:105:854887
Lasić, Hrvoje
University of Zagreb
School of Medicine

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Lasić, H. (2024). Manjak fibrinogena i primjena viskoelastičnih testova u bolesnika s traumatskom koagulopatijom (Professional thesis). Zagreb: University of Zagreb, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:854887

Lasić, Hrvoje. "Manjak fibrinogena i primjena viskoelastičnih testova u bolesnika s traumatskom koagulopatijom." Professional thesis, University of Zagreb, School of Medicine, 2024. https://urn.nsk.hr/urn:nbn:hr:105:854887

Lasić, Hrvoje. "Manjak fibrinogena i primjena viskoelastičnih testova u bolesnika s traumatskom koagulopatijom." Professional thesis, University of Zagreb, School of Medicine, 2024. https://urn.nsk.hr/urn:nbn:hr:105:854887

Lasić, H. (2024). 'Manjak fibrinogena i primjena viskoelastičnih testova u bolesnika s traumatskom koagulopatijom', Professional thesis, University of Zagreb, School of Medicine, accessed 03 January 2025, https://urn.nsk.hr/urn:nbn:hr:105:854887

Lasić H. Manjak fibrinogena i primjena viskoelastičnih testova u bolesnika s traumatskom koagulopatijom [Professional thesis]. Zagreb: University of Zagreb, School of Medicine; 2024 [cited 2025 January 03] Available at: https://urn.nsk.hr/urn:nbn:hr:105:854887

H. Lasić, "Manjak fibrinogena i primjena viskoelastičnih testova u bolesnika s traumatskom koagulopatijom", Professional thesis, University of Zagreb, School of Medicine, Zagreb, 2024. Available at: https://urn.nsk.hr/urn:nbn:hr:105:854887

Metadata
TitleManjak fibrinogena i primjena viskoelastičnih testova u bolesnika s traumatskom koagulopatijom
Title (english)Fibrinogen deficiency and use of viscoelastic tests in patients with trauma induced coagulopathy
AuthorHrvoje Lasić
MentorJasminka Peršec (mentor)
MentorBranko Tripković (komentor)
GranterUniversity of Zagreb
School of Medicine
Zagreb
Defense date and country2024-04-09, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Anesthesiology and Reanimatology
Abstract
Uvod: Traumatske ozljede su i dalje vodeći uzrok morbiditeta i mortaliteta kod odraslih, unatoč napretku u kirurškom zbrinjavaju i intenzivnom liječenju. Rana faza traumatske koagulopatije karakterizirana je nemogućnošću postizanja hemostaze, što može dovesti do nekontroliranog krvarenja i protrahiranog stanja šoka. Tijekom teškog krvarenja fibrinogen postiže vrlo niske vrijednosti u plazmi, ranije nego drugi faktori koagulacije. Viskoelastični testovi mogu dati informaciju o pravovremenoj potrebi za cuplementacijom fibrinogena. Cilj rada: Cilj ovog rada je iz novije publiciranih radova i literature sažeti najnovija saznanja o manjku i nadoknadi fibrinogena kod bolesnika s traumom. Obuhvaćena je primjena i uloga viskoelastičnih testova u procesu liječenja. Metode: Rad je kroz pregled publiciranih radova u bazi PubMed, u periodu od 5 godina (2017.-2022.) sažeo najnovija saznanja iz istraživanog područja. Analizirale su se novije randomizirane studije, meta-analize i pregledni članci iz područja traumatske koagulopatije. Rezultati: Bolesnici koji razviju traumatsku koagulopatiju imaju povišen rizik od smrtnog ishoda. Tijekom teškog krvarenja potrebno je razmotriti empirijsku nadoknadu fibrinogena u ranoj fazi krvarenja. Viskoelastični testovi su korisni u prognoziranju daljnjeg razvoja situacije. Zaključak: U stanju traumatske koagulopatije niske razine fibrinogena i nemogućnost postizanja hemostaze iziskuju promišljanje o ciljanoj nadoknadi ovog faktora. Prema mogućnostima poželjno je koristiti viskoelastične testove radi procjene manjka i donošenja terapijskih odluka.
Abstract (english)
Introduction: Trauma injuries are still the leading cause of morbidity and mortality in adults, despite improvement in surgical and intensive care. Early phase of traumatic coagulopathy is characterized by impossibility to achieve hemostasis, which can lead to uncontrollable bleeding and prolonged state of shock. During serious bleeding fibrinogen in blood reaches very low levels earlier than other coagulation factors. Viscoelastic tests can give us information about timely supplementation of fibrinogen. Goal: To summarize information about fibrinogen deficiency and supplementation in trauma patients in newer publications and literature. The role of viscoelastic tests in the process is also included. Methods: Research of publications in PubMed base through the period of 5 years (2017.-2022.). This paper concluded the newest facts and information from this topic. In this paper randomized studies, meta-analyses and systematic reviews concerning traumatic coagulopathy were analyzed. Results: Patients that develop traumatic coagulopathy have increased risk from death. During serious bleeding fibrinogen it is important to consider empirical fibrinogen supplementation during the early phase. Viscoelastic tests are useful in projecting next steps in management. Conclusion: During the state of traumatic coagulopathy low levels of fibrinogen and impossibility to reach hemostasis demand considering goal oriented supplementation of this factor. It is prudent to use viscoelastic tests for orientation about fibrinogen deficiency and about further therapeutic decisions.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:105:854887
Study programmeTitle: Anesthesiology, reanimatology and intensive care medicine
Study programme type: university
Study level: postgraduate specialist
Academic / professional title: sveučilišni/a magistar/magistra anesteziologije, reanimatologije i intenzivne medicine (sveučilišni/a magistar/magistra anesteziologije, reanimatologije i intenzivne medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
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Created on2024-06-19 11:57:22