Over the past few decades, assisted reproductive techniques (ART), including the process of in vitro fertilization (IVF), has significantly developed. Thanks to these advancements, the risks and undesirable outcomes of the procedure have been reduced. Twin pregnancy, being one of them, is inherently more risky than singleton pregnancy, and it has long been debated whether the process of in vitro fertilization makes it even riskier. Despite many contradictions and differences between studies comparing the outcomes of spontaneously conceived twin pregnancies and twin pregnancies from in vitro fertilization, all have shown that the in vitro fertilization process only further increases the risk of preterm birth, and consequently the number of hospitalizations in the neonatal intensive care unit. Nowadays, twin pregnancies from ART can be avoided, and for this purpose, the European Society of Human Reproduction and Embryology (ESHRE) has issued new recommendations for specialists in human reproduction. These recommendations compare all possible benefits and disadvantages of elective single embryo transfer (eSET) and double embryo transfer (DET) considering the psychosocial, financial, and clinical factors of the patients, as well as the policy and rights of the country in which the MAR is performed. The guideline's recommendation is, after taking all factors into account, a single elective embryo transfer (eSET) instead of multiple ones, which reduces the chance of twin pregnancy as an outcome of ART and avoids the complications associated with twin pregnancies.