With the rapid increase in Parkinson's disease cases worldwide, there is a growing need for timely recognition and treatment of advanced stages of the disease. Advanced Parkinson's disease is characterized by the emergence of severe motor and non-motor symptoms and a significant decline in the quality of life for patients and their caregivers. Typical motor symptoms include dyskinesias and motor symptoms resulting from prolonged use of conventional pharmacological therapy. Non-motor symptoms in advanced stages include hallucinations, cognitive decline, and the onset of dementia. In clinical assessment of disease progression, it is crucial to individualize the approach and use additional supportive tools such as questionnaires on motor and non-motor symptoms. When symptoms of advanced disease appear, advanced treatment methods should be recommended to patients. These include levodopa/carbidopa intestinal gel (LCIG), continuous subcutaneous infusion of apomorphine (CSAI), and deep brain stimulation (DBS). By educating patients, neurologists, and general practitioners, an optimal approach to patients with advanced Parkinson's disease can be achieved. Timely recognition of symptoms in advanced stages of the disease opens up the possibility of treatment with advanced methods, which are suitable after the loss of effectiveness of conventional pharmacological therapy.