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master's thesis
Utjecaj opće anestezije na mozak u razvoju
Zagreb: University of Zagreb, School of Medicine, 2024. urn:nbn:hr:105:414356
Adamović, Adriana
University of Zagreb
School of Medicine

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Adamović, A. (2024). Utjecaj opće anestezije na mozak u razvoju (Master's thesis). Zagreb: University of Zagreb, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:414356

Adamović, Adriana. "Utjecaj opće anestezije na mozak u razvoju." Master's thesis, University of Zagreb, School of Medicine, 2024. https://urn.nsk.hr/urn:nbn:hr:105:414356

Adamović, Adriana. "Utjecaj opće anestezije na mozak u razvoju." Master's thesis, University of Zagreb, School of Medicine, 2024. https://urn.nsk.hr/urn:nbn:hr:105:414356

Adamović, A. (2024). 'Utjecaj opće anestezije na mozak u razvoju', Master's thesis, University of Zagreb, School of Medicine, accessed 09 August 2024, https://urn.nsk.hr/urn:nbn:hr:105:414356

Adamović A. Utjecaj opće anestezije na mozak u razvoju [Master's thesis]. Zagreb: University of Zagreb, School of Medicine; 2024 [cited 2024 August 09] Available at: https://urn.nsk.hr/urn:nbn:hr:105:414356

A. Adamović, "Utjecaj opće anestezije na mozak u razvoju", Master's thesis, University of Zagreb, School of Medicine, Zagreb, 2024. Available at: https://urn.nsk.hr/urn:nbn:hr:105:414356

Metadata
TitleUtjecaj opće anestezije na mozak u razvoju
Title (english)The effect of general anesthesia on a developing brain
AuthorAdriana Adamović
MentorVilena Vrbanović Mijatović (mentor)
Committee memberDaniela Bandić Pavlović (predsjednik povjerenstva)
Committee memberDinko Tonković (član povjerenstva)
Committee memberVilena Vrbanović Mijatović (član povjerenstva)
GranterUniversity of Zagreb
School of Medicine
Zagreb
Defense date and country2024-07-12, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Anesthesiology and Reanimatology
Abstract
Opća anestezija sigurna je rutinska metoda koja se danas često primjenjuje u djece. Uvod u anesteziju postiže se intravenskim ili inhalacijskim anesteticima. Najčešće primjenjivani intravenski anestetici su propofol, etomidat, tiopental i ketamin, a inhalacijski dušikov oksidul i sevofluran. Djelovanje anestetika na mozak uključuje više mehanizama, a najvažniji od njih je modulacija djelovanja ekscitacijskih i inhibicijskih neurotransmitera. Mnogo je istraživanja provedeno na životinjama koja pokazuju da primjena anestetika u mladunčadi dovodi do kasnijih poremećaja učenja i pamćenja te slabije prostorne memorije. Klinička su istraživanja također pokazala da anestetici imaju utjecaj na slabiji motorički i kognitivni razvoj u kasnijoj dobi djeteta. Anestezijom kraćeg trajanja, manjom dozom lijekova te njihovom kombiniranom primjenom može se smanjiti štetnost utjecaja anestetika na mozak u razvoju.
Abstract (english)
General anesthesia is a standard and safe procedure frequently utilized in pediatric practice today. Induction of anesthesia is achieved with intravenous or inhalation anesthetics. The most commonly used intravenous anesthetics are propofol, etomidate, thiopental and ketamine, while the most frequently used inhalation anesthetics are nitrous oxide and sevoflurane. The effects of anesthetics on the brain involve multiple mechanisms, the most important of which is the modulation of excitatory and inhibitory neurotransmitter activity. Numerous studies conducted on animals have shown that the administration of anesthetics in young animals leads to subsequent learning and memory disorders, as well as impaired spatial memory. Clinical studies have also demonstrated that anesthetics can impact poorer motor and cognitive development later in childhood. Shorter-duration anesthesia, lower drug doses, and their combined use can reduce the harmful effects of anesthetics on the developing brain.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:105:414356
Study programmeTitle: Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-06-26 13:43:10