Drugs from the statin group reduce blood cholesterol levels by inhibiting the enzyme HMG-CoA reductase. Over several years of widespread use, additional pleiotropic effects of statins have been discovered. Statins possess anti-inflammatory, antioxidant, anti-aggregatory, and anti-proliferative properties. The main aim of this study was to determine the impact of these properties on the outcome and course of acute diverticulitis. In the conducted study, 120 patients who were treated at the Emergency Department of the Clinical Hospital Center Zagreb for an episode of acute diverticulitis between 1st of January, 2023 and 1st of January, 2024 were retrospectively observed. Patients on statins and patients without statins in their therapy were matched based on propensity scores, and indicators of disease severity (CRP values, leukocyte count, percentage of hospitalized patients, duration of hospitalization) were defined. A correlation was found between statin therapy and the aforementioned indicators of disease severity. CRP levels, leukocyte count, and the percentage of hospitalized patients indicated a milder course of the disease in patients on statin therapy, while the duration of hospitalization was the same in both groups of patients. Laboratory indicators along with the percentage of hospitalized patients indicated a positive effect of statin therapy on the outcome and course of acute diverticulitis. These results are consistent with the results of other studies that have examined the effect of statins on other inflammatory diseases. The potential practical application of the findings should primarily be considered in a specific population of patients with frequent recurrences of the disease, as well as those with a severe episode of acute diverticulitis in their history. Future prospective studies with a larger number of patients and clearly defined disease outcomes will complement the results of this study and more clearly define the potential practical application of the finding.